Unreviewed, UniProtKB/TrEMBL Q17R61 (Q17R61_HUMAN)

Names and origin

Protein names

Submitted name:
    C-abl oncogene 1, receptor tyrosine kinase EMBL AAI17452.1

Gene names

Name:	ABL1 EMBL AAI17452.1
ORF Names:	RP11-83J21.1-002 EMBL CAM45756.1

Organism

Homo sapiens (Human) EMBL AAI17452.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM000980
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307V5 Contains 1 SH2 domain. Spearmint SPM000980 Contains 1 SH3 domain. RuleBase RU003338V3 Spearmint SPM000980 Contains 1 protein kinase domain. Spearmint SPM000980

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM000980 Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase RuleBase RU000307V5
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q17R61-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: DF9D4512F78FFE52	FASTA	1,149	124,955
	10 20 30 40 50 60 MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 70 80 90 100 110 120 LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 130 140 150 160 170 180 AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR 190 200 210 220 230 240 SISLRYEGRV YHYRINTASD GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN 250 260 270 280 290 300 KPTVYGVSPN YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 310 320 330 340 350 360 EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL 370 380 390 400 410 420 YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF 430 440 450 460 470 480 PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP 490 500 510 520 530 540 EGCPEKVYEL MRACWQWNPS DRPSFAEIHQ AFETMFQESS ISDEVEKELG KQGVRGAVST 550 560 570 580 590 600 LLQAPELPTK TRTSRRAAEH RDTTDVPEMP HSKGQGESDP LDHEPAVSPL LPRKERGPPE 610 620 630 640 650 660 GGLNEDERLL PKDKKTNLFS ALIKKKKKTA PTPPKRSSSF REMDGQPERR GAGEEEGRDI 670 680 690 700 710 720 SNGALAFTPL DTADPAKSPK PSNGAGVPNG ALRESGGSGF RSPHLWKKSS TLTSSRLATG 730 740 750 760 770 780 EEEGGGSSSK RFLRSCSASC VPHGAKDTEW RSVTLPRDLQ STGRQFDSST FGGHKSEKPA 790 800 810 820 830 840 LPRKRAGENR SDQVTRGTVT PPPRLVKKNE EAADEVFKDI MESSPGSSPP NLTPKPLRRQ 850 860 870 880 890 900 VTVAPASGLP HKEEAGKGSA LGTPAAAEPV TPTSKAGSGA PGGTSKGPAE ESRVRRHKHS 910 920 930 940 950 960 SESPGRDKGK LSRLKPAPPP PPAASAGKAG GKPSQSPSQE AAGEAVLGAK TKATSLVDAV 970 980 990 1000 1010 1020 NSDAAKPSQP GEGLKKPVLP ATPKPQSAKP SGTPISPAPV PSTLPSASSA LAGDQPSSTA 1030 1040 1050 1060 1070 1080 FIPLISTRVS LRKTRQPPER IASGAITKGV VLDSTEALCL AISRNSEQMA SHSAVLEAGK 1090 1100 1110 1120 1130 1140 NLYTFCVSYV DSIQQMRNKF AFREAINKLE NNLRELQICP ATAGSGPAAT QDFSKLLSSV KEISDIVQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum EMBL AAI17452.1.
[2]	Garner P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Lloyd D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC117451 mRNA. Translation: AAI17452.1. AL359092, AL161733 Genomic DNA. Translation: CAM45752.1. AL161733, AL359092 Genomic DNA. Translation: CAM45756.1.
IPI	IPI00221171.
RefSeq	NP_009297.2.
UniGene	Hs.431048
3D structure databases
SMR	Q17R61. Positions 83-531, 1043-1149.
ModBase	Search...
Proteomic databases
PRIDE	Q17R61.
Genome annotation databases
Ensembl	ENSG00000097007. Homo sapiens. [Contig view]
GeneID	25.
Organism-specific databases
HGNC	HGNC:76. ABL1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q17R61.
OMA	Q17R61. GAFRESG.
Gene expression databases
ArrayExpress	Q17R61.
Bgee	Q17R61.
Family and domain databases
InterPro	IPR015015. F-actin_binding. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001452. SH3_domain. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF08919. F_actin_bind. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. PD000093. SH2. 1 hit. PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00808. FABD. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	79.

Entry information

Entry name

Q17R61_HUMAN

Accession

Primary (citable) accession number: Q17R61

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)