Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q17R60

- IMPG1_HUMAN

UniProt

Q17R60 - IMPG1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interphotoreceptor matrix proteoglycan 1

Gene

IMPG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.1 Publication

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

  1. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name:
IPM-150
Sialoprotein associated with cones and rods
Gene namesi
Name:IMPG1Imported
Synonyms:IPM150Imported, SPACR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6055. IMPG1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti99000. Adult-onset foveomacular vitelliform dystrophy.
PharmGKBiPA29865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 797777Interphotoreceptor matrix proteoglycan 1Sequence AnalysisPRO_0000252238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031O-linked (GalNAc...)Sequence Analysis
Glycosylationi421 – 4211O-linked (GalNAc...)Sequence Analysis
Glycosylationi432 – 4321O-linked (GalNAc...)Sequence Analysis
Glycosylationi442 – 4421O-linked (GalNAc...)Sequence Analysis
Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi648 – 6481N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The N-terminus is blocked.1 Publication
Highly glycosylated (N- and O-linked carbohydrates and sialic acid).1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ17R60.
PRIDEiQ17R60.

PTM databases

PhosphoSiteiQ17R60.

Expressioni

Tissue specificityi

Abundantly expressed in retina where it is specifically expressed by cone and rod photoreceptor cells. Localizes to cone and rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina.3 Publications

Gene expression databases

BgeeiQ17R60.
CleanExiHS_IMPG1.
ExpressionAtlasiQ17R60. baseline.
GenevestigatoriQ17R60.

Interactioni

Protein-protein interaction databases

BioGridi109830. 1 interaction.
STRINGi9606.ENSP00000358966.

Structurei

3D structure databases

ProteinModelPortaliQ17R60.
SMRiQ17R60. Positions 576-631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 354123SEA 1PROSITE-ProRule annotationAdd
BLAST
Domaini571 – 684114SEA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 SEA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG73774.
GeneTreeiENSGT00530000063503.
HOGENOMiHOG000113063.
HOVERGENiHBG081793.
InParanoidiQ17R60.
OMAiQMQKVFK.
OrthoDBiEOG7TXKFR.
PhylomeDBiQ17R60.
TreeFamiTF331340.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR000742. EG-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 2 hits.
[Graphical view]
SMARTiSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiPS50024. SEA. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q17R60-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK
60 70 80 90 100
MYKMSTMRRI FDLAKHRTKR SAFFPTGVKV CPQESMKQIL DSLQAYYRLR
110 120 130 140 150
VCQEAVWEAY RIFLDRIPDT GEYQDWVSIC QQETFCLFDI GKNFSNSQEH
160 170 180 190 200
LDLLQQRIKQ RSFPDRKDEI SAEKTLGEPG ETIVISTDVA NVSLGPFPLT
210 220 230 240 250
PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV SLVNQKFKAE
260 270 280 290 300
LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST
310 320 330 340 350
EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL
360 370 380 390 400
TATDLKRLIS KALEEEQSLD VGTIQFTDEI AGSLPAFGPD TQSELPTSFA
410 420 430 440 450
VITEDATLSP ELPPVEPQLE TVDGAEHGLP DTSWSPPAMA STSLSEAPPF
460 470 480 490 500
FMASSIFSLT DQGTTDTMAT DQTMLVPGLT IPTSDYSAIS QLALGISHPP
510 520 530 540 550
ASSDDSRSSA GGEDMVRHLD EMDLSDTPAP SEVPELSEYV SVPDHFLEDT
560 570 580 590 600
TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA
610 620 630 640 650
LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT
660 670 680 690 700
KAVHGVLEDF RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV
710 720 730 740 750
KNERTEEAEC RCKPGYDSQG SLDGLEPGLC GPGTKECEVL QGKGAPCRLP
760 770 780 790
DHSENQAYKT SVKKFQNQQN NKVISKRNSE LLTVEYEEFN HQDWEGN
Length:797
Mass (Da):89,387
Last modified:October 3, 2006 - v2
Checksum:iD017ED090C78D521
GO
Isoform 2 (identifier: Q17R60-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-100: Missing.
     188-225: DVANVSLGPF...DTKMPTTERE → EKNKGKTKPF...LLSSIIYTYY
     226-797: Missing.

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):17,389
Checksum:i2E719607077AC85C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti463 – 4631G → V.
Corresponds to variant rs9443201 [ dbSNP | Ensembl ].
VAR_051069
Natural varianti518 – 5181H → D.1 Publication
Corresponds to variant rs3734311 [ dbSNP | Ensembl ].
VAR_027793
Natural varianti569 – 5691K → R.
Corresponds to variant rs3734312 [ dbSNP | Ensembl ].
VAR_051070
Natural varianti704 – 7041R → W.1 Publication
Corresponds to variant rs10943299 [ dbSNP | Ensembl ].
VAR_027794
Natural varianti711 – 7111R → H.
Corresponds to variant rs3734313 [ dbSNP | Ensembl ].
VAR_051071
Natural varianti761 – 7611S → N.
Corresponds to variant rs3778005 [ dbSNP | Ensembl ].
VAR_051072

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 10078Missing in isoform 2. 1 PublicationVSP_055981Add
BLAST
Alternative sequencei188 – 22538DVANV…TTERE → EKNKGKTKPFNILQFGNNHH EHLLPIFCLLSSIIYTYY in isoform 2. 1 PublicationVSP_055982Add
BLAST
Alternative sequencei226 – 797572Missing in isoform 2. 1 PublicationVSP_055983Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017776
, AF017760, AF017761, AF017762, AF017763, AF017764, AF017765, AF017766, AF017767, AF017768, AF017769, AF017770, AF017771, AF017772, AF017773, AF017774, AF017775 Genomic DNA. Translation: AAC68835.1.
AF047492 mRNA. Translation: AAC03789.2.
CR749572 mRNA. Translation: CAH18367.1.
AL356962, AL392166 Genomic DNA. Translation: CAC36327.2.
AL392166, AL356962 Genomic DNA. Translation: CAI41298.1.
CH471051 Genomic DNA. Translation: EAW48726.1.
BC117450 mRNA. Translation: AAI17451.1.
BC117452 mRNA. Translation: AAI17453.1.
CCDSiCCDS4985.1. [Q17R60-1]
RefSeqiNP_001269297.1. NM_001282368.1.
NP_001554.2. NM_001563.3. [Q17R60-1]
UniGeneiHs.590893.

Genome annotation databases

EnsembliENST00000369950; ENSP00000358966; ENSG00000112706. [Q17R60-1]
ENST00000369963; ENSP00000358980; ENSG00000112706. [Q17R60-2]
GeneIDi3617.
KEGGihsa:3617.
UCSCiuc003pik.1. human. [Q17R60-1]

Polymorphism databases

DMDMi115502232.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017776
, AF017760 , AF017761 , AF017762 , AF017763 , AF017764 , AF017765 , AF017766 , AF017767 , AF017768 , AF017769 , AF017770 , AF017771 , AF017772 , AF017773 , AF017774 , AF017775 Genomic DNA. Translation: AAC68835.1 .
AF047492 mRNA. Translation: AAC03789.2 .
CR749572 mRNA. Translation: CAH18367.1 .
AL356962 , AL392166 Genomic DNA. Translation: CAC36327.2 .
AL392166 , AL356962 Genomic DNA. Translation: CAI41298.1 .
CH471051 Genomic DNA. Translation: EAW48726.1 .
BC117450 mRNA. Translation: AAI17451.1 .
BC117452 mRNA. Translation: AAI17453.1 .
CCDSi CCDS4985.1. [Q17R60-1 ]
RefSeqi NP_001269297.1. NM_001282368.1.
NP_001554.2. NM_001563.3. [Q17R60-1 ]
UniGenei Hs.590893.

3D structure databases

ProteinModelPortali Q17R60.
SMRi Q17R60. Positions 576-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109830. 1 interaction.
STRINGi 9606.ENSP00000358966.

PTM databases

PhosphoSitei Q17R60.

Polymorphism databases

DMDMi 115502232.

Proteomic databases

PaxDbi Q17R60.
PRIDEi Q17R60.

Protocols and materials databases

DNASUi 3617.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369950 ; ENSP00000358966 ; ENSG00000112706 . [Q17R60-1 ]
ENST00000369963 ; ENSP00000358980 ; ENSG00000112706 . [Q17R60-2 ]
GeneIDi 3617.
KEGGi hsa:3617.
UCSCi uc003pik.1. human. [Q17R60-1 ]

Organism-specific databases

CTDi 3617.
GeneCardsi GC06M076687.
HGNCi HGNC:6055. IMPG1.
MIMi 602870. gene.
neXtProti NX_Q17R60.
Orphaneti 99000. Adult-onset foveomacular vitelliform dystrophy.
PharmGKBi PA29865.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73774.
GeneTreei ENSGT00530000063503.
HOGENOMi HOG000113063.
HOVERGENi HBG081793.
InParanoidi Q17R60.
OMAi QMQKVFK.
OrthoDBi EOG7TXKFR.
PhylomeDBi Q17R60.
TreeFami TF331340.

Miscellaneous databases

GeneWikii IMPG1.
GenomeRNAii 3617.
NextBioi 14149.
PROi Q17R60.
SOURCEi Search...

Gene expression databases

Bgeei Q17R60.
CleanExi HS_IMPG1.
ExpressionAtlasi Q17R60. baseline.
Genevestigatori Q17R60.

Family and domain databases

Gene3Di 3.30.70.960. 2 hits.
InterProi IPR000742. EG-like_dom.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 2 hits.
[Graphical view ]
SMARTi SM00200. SEA. 2 hits.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 2 hits.
PROSITEi PS50024. SEA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies."
    Felbor U., Gehrig A., Sauer C.G., Marquardt A., Koehler M., Schmid M., Weber B.H.F.
    Cytogenet. Cell Genet. 81:12-17(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan."
    Kuehn M.H., Hageman G.S.
    Matrix Biol. 18:509-518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 71-90, TISSUE SPECIFICITY.
    Tissue: RetinaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-518 AND TRP-704.
    Tissue: BrainImported.
  7. "SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan."
    Acharya S., Rodriguez I.R., Moreira E.F., Midura R.J., Misono K., Todres E., Hollyfield J.G.
    J. Biol. Chem. 273:31599-31606(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 71-79; 101-111; 249-265 AND 622-629, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis."
    Acharya S., Rayborn M.E., Hollyfield J.G.
    Glycobiology 8:997-1006(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.

Entry informationi

Entry nameiIMPG1_HUMAN
AccessioniPrimary (citable) accession number: Q17R60
Secondary accession number(s): A6NNZ6
, O43686, O95094, Q68D53, Q9BWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 26, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3