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Q17R60 (IMPG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name=IPM-150
Sialoprotein associated with cones and rods
Gene names
Name:IMPG1
Synonyms:IPM150, SPACR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix. Ref.6

Subcellular location

Secreted Potential Ref.6 Ref.7.

Tissue specificity

Abundantly expressed in retina where it is specifically expressed by cone and rod photoreceptor cells. Localizes to cone and rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina. Ref.2 Ref.6 Ref.7

Post-translational modification

The N-terminus is blocked. Ref.7

Highly glycosylated (N- and O-linked carbohydrates and sialic acid). Ref.7

Sequence similarities

Contains 2 SEA domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   LigandSialic acid
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processvisual perception

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentproteinaceous extracellular matrix

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionextracellular matrix structural constituent

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 797777Interphotoreceptor matrix proteoglycan 1
PRO_0000252238

Regions

Domain232 – 354123SEA 1
Domain571 – 684114SEA 2

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation4031O-linked (GalNAc...) Potential
Glycosylation4211O-linked (GalNAc...) Potential
Glycosylation4321O-linked (GalNAc...) Potential
Glycosylation4421O-linked (GalNAc...) Potential
Glycosylation5921N-linked (GlcNAc...) Potential
Glycosylation6161N-linked (GlcNAc...) Potential
Glycosylation6301N-linked (GlcNAc...) Potential
Glycosylation6481N-linked (GlcNAc...) Potential

Natural variations

Natural variant4631G → V.
Corresponds to variant rs9443201 [ dbSNP | Ensembl ].
VAR_051069
Natural variant5181H → D. Ref.5
Corresponds to variant rs3734311 [ dbSNP | Ensembl ].
VAR_027793
Natural variant5691K → R.
Corresponds to variant rs3734312 [ dbSNP | Ensembl ].
VAR_051070
Natural variant7041R → W. Ref.5
Corresponds to variant rs10943299 [ dbSNP | Ensembl ].
VAR_027794
Natural variant7111R → H.
Corresponds to variant rs3734313 [ dbSNP | Ensembl ].
VAR_051071
Natural variant7611S → N.
Corresponds to variant rs3778005 [ dbSNP | Ensembl ].
VAR_051072

Sequences

Sequence LengthMass (Da)Tools
Q17R60 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: D017ED090C78D521

FASTA79789,387
        10         20         30         40         50         60 
MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK MYKMSTMRRI 

        70         80         90        100        110        120 
FDLAKHRTKR SAFFPTGVKV CPQESMKQIL DSLQAYYRLR VCQEAVWEAY RIFLDRIPDT 

       130        140        150        160        170        180 
GEYQDWVSIC QQETFCLFDI GKNFSNSQEH LDLLQQRIKQ RSFPDRKDEI SAEKTLGEPG 

       190        200        210        220        230        240 
ETIVISTDVA NVSLGPFPLT PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV 

       250        260        270        280        290        300 
SLVNQKFKAE LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST 

       310        320        330        340        350        360 
EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL TATDLKRLIS 

       370        380        390        400        410        420 
KALEEEQSLD VGTIQFTDEI AGSLPAFGPD TQSELPTSFA VITEDATLSP ELPPVEPQLE 

       430        440        450        460        470        480 
TVDGAEHGLP DTSWSPPAMA STSLSEAPPF FMASSIFSLT DQGTTDTMAT DQTMLVPGLT 

       490        500        510        520        530        540 
IPTSDYSAIS QLALGISHPP ASSDDSRSSA GGEDMVRHLD EMDLSDTPAP SEVPELSEYV 

       550        560        570        580        590        600 
SVPDHFLEDT TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA 

       610        620        630        640        650        660 
LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT KAVHGVLEDF 

       670        680        690        700        710        720 
RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV KNERTEEAEC RCKPGYDSQG 

       730        740        750        760        770        780 
SLDGLEPGLC GPGTKECEVL QGKGAPCRLP DHSENQAYKT SVKKFQNQQN NKVISKRNSE 

       790 
LLTVEYEEFN HQDWEGN 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies."
Felbor U., Gehrig A., Sauer C.G., Marquardt A., Koehler M., Schmid M., Weber B.H.F.
Cytogenet. Cell Genet. 81:12-17(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan."
Kuehn M.H., Hageman G.S.
Matrix Biol. 18:509-518(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 71-90, TISSUE SPECIFICITY.
Tissue: Retina.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-518 AND TRP-704.
Tissue: Brain.
[6]"SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan."
Acharya S., Rodriguez I.R., Moreira E.F., Midura R.J., Misono K., Todres E., Hollyfield J.G.
J. Biol. Chem. 273:31599-31606(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 71-79; 101-111; 249-265 AND 622-629, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis."
Acharya S., Rayborn M.E., Hollyfield J.G.
Glycobiology 8:997-1006(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017776 expand/collapse EMBL AC list , AF017760, AF017761, AF017762, AF017763, AF017764, AF017765, AF017766, AF017767, AF017768, AF017769, AF017770, AF017771, AF017772, AF017773, AF017774, AF017775 Genomic DNA. Translation: AAC68835.1.
AF047492 mRNA. Translation: AAC03789.2.
AL356962, AL392166 Genomic DNA. Translation: CAC36327.2.
AL392166, AL356962 Genomic DNA. Translation: CAI41298.1.
CH471051 Genomic DNA. Translation: EAW48726.1.
BC117450 mRNA. Translation: AAI17451.1.
BC117452 mRNA. Translation: AAI17453.1.
CCDSCCDS4985.1.
RefSeqNP_001269297.1. NM_001282368.1.
NP_001554.2. NM_001563.3.
UniGeneHs.590893.

3D structure databases

ProteinModelPortalQ17R60.
SMRQ17R60. Positions 576-631.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109830. 1 interaction.
STRING9606.ENSP00000358966.

PTM databases

PhosphoSiteQ17R60.

Polymorphism databases

DMDM115502232.

Proteomic databases

PaxDbQ17R60.
PRIDEQ17R60.

Protocols and materials databases

DNASU3617.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369950; ENSP00000358966; ENSG00000112706.
GeneID3617.
KEGGhsa:3617.
UCSCuc003pik.1. human.

Organism-specific databases

CTD3617.
GeneCardsGC06M076687.
HGNCHGNC:6055. IMPG1.
MIM602870. gene.
neXtProtNX_Q17R60.
Orphanet99000. Adult-onset foveomacular vitelliform dystrophy.
PharmGKBPA29865.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG73774.
HOGENOMHOG000113063.
HOVERGENHBG081793.
InParanoidQ17R60.
OMAQMQKVFK.
OrthoDBEOG7TXKFR.
PhylomeDBQ17R60.
TreeFamTF331340.

Gene expression databases

ArrayExpressQ17R60.
BgeeQ17R60.
CleanExHS_IMPG1.
GenevestigatorQ17R60.

Family and domain databases

Gene3D3.30.70.960. 2 hits.
InterProIPR000742. EG-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamPF01390. SEA. 2 hits.
[Graphical view]
SMARTSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMSSF82671. SSF82671. 2 hits.
PROSITEPS50024. SEA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIMPG1.
GenomeRNAi3617.
NextBio14149.
PROQ17R60.
SOURCESearch...

Entry information

Entry nameIMPG1_HUMAN
AccessionPrimary (citable) accession number: Q17R60
Secondary accession number(s): A6NNZ6 expand/collapse secondary AC list , O43686, O95094, Q9BWZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM