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Q17R60

- IMPG1_HUMAN

UniProt

Q17R60 - IMPG1_HUMAN

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Protein
Interphotoreceptor matrix proteoglycan 1
Gene
IMPG1, IPM150, SPACR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.1 Publication

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

  1. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name:
IPM-150
Sialoprotein associated with cones and rods
Gene namesi
Name:IMPG1
Synonyms:IPM150, SPACR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6055. IMPG1.

Subcellular locationi

Secreted Reviewed prediction 2 Publications

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti99000. Adult-onset foveomacular vitelliform dystrophy.
PharmGKBiPA29865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 797777Interphotoreceptor matrix proteoglycan 1
PRO_0000252238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi403 – 4031O-linked (GalNAc...) Reviewed prediction
Glycosylationi421 – 4211O-linked (GalNAc...) Reviewed prediction
Glycosylationi432 – 4321O-linked (GalNAc...) Reviewed prediction
Glycosylationi442 – 4421O-linked (GalNAc...) Reviewed prediction
Glycosylationi592 – 5921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi616 – 6161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi648 – 6481N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The N-terminus is blocked.1 Publication
Highly glycosylated (N- and O-linked carbohydrates and sialic acid).1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ17R60.
PRIDEiQ17R60.

PTM databases

PhosphoSiteiQ17R60.

Expressioni

Tissue specificityi

Abundantly expressed in retina where it is specifically expressed by cone and rod photoreceptor cells. Localizes to cone and rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina.3 Publications

Gene expression databases

ArrayExpressiQ17R60.
BgeeiQ17R60.
CleanExiHS_IMPG1.
GenevestigatoriQ17R60.

Interactioni

Protein-protein interaction databases

BioGridi109830. 1 interaction.
STRINGi9606.ENSP00000358966.

Structurei

3D structure databases

ProteinModelPortaliQ17R60.
SMRiQ17R60. Positions 576-631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 354123SEA 1
Add
BLAST
Domaini571 – 684114SEA 2
Add
BLAST

Sequence similaritiesi

Contains 2 SEA domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG73774.
HOGENOMiHOG000113063.
HOVERGENiHBG081793.
InParanoidiQ17R60.
OMAiQMQKVFK.
OrthoDBiEOG7TXKFR.
PhylomeDBiQ17R60.
TreeFamiTF331340.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR000742. EG-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 2 hits.
[Graphical view]
SMARTiSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiPS50024. SEA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17R60-1 [UniParc]FASTAAdd to Basket

« Hide

MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK    50
MYKMSTMRRI FDLAKHRTKR SAFFPTGVKV CPQESMKQIL DSLQAYYRLR 100
VCQEAVWEAY RIFLDRIPDT GEYQDWVSIC QQETFCLFDI GKNFSNSQEH 150
LDLLQQRIKQ RSFPDRKDEI SAEKTLGEPG ETIVISTDVA NVSLGPFPLT 200
PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV SLVNQKFKAE 250
LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST 300
EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL 350
TATDLKRLIS KALEEEQSLD VGTIQFTDEI AGSLPAFGPD TQSELPTSFA 400
VITEDATLSP ELPPVEPQLE TVDGAEHGLP DTSWSPPAMA STSLSEAPPF 450
FMASSIFSLT DQGTTDTMAT DQTMLVPGLT IPTSDYSAIS QLALGISHPP 500
ASSDDSRSSA GGEDMVRHLD EMDLSDTPAP SEVPELSEYV SVPDHFLEDT 550
TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA 600
LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT 650
KAVHGVLEDF RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV 700
KNERTEEAEC RCKPGYDSQG SLDGLEPGLC GPGTKECEVL QGKGAPCRLP 750
DHSENQAYKT SVKKFQNQQN NKVISKRNSE LLTVEYEEFN HQDWEGN 797
Length:797
Mass (Da):89,387
Last modified:October 3, 2006 - v2
Checksum:iD017ED090C78D521
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti463 – 4631G → V.
Corresponds to variant rs9443201 [ dbSNP | Ensembl ].
VAR_051069
Natural varianti518 – 5181H → D.1 Publication
Corresponds to variant rs3734311 [ dbSNP | Ensembl ].
VAR_027793
Natural varianti569 – 5691K → R.
Corresponds to variant rs3734312 [ dbSNP | Ensembl ].
VAR_051070
Natural varianti704 – 7041R → W.1 Publication
Corresponds to variant rs10943299 [ dbSNP | Ensembl ].
VAR_027794
Natural varianti711 – 7111R → H.
Corresponds to variant rs3734313 [ dbSNP | Ensembl ].
VAR_051071
Natural varianti761 – 7611S → N.
Corresponds to variant rs3778005 [ dbSNP | Ensembl ].
VAR_051072

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017776
, AF017760, AF017761, AF017762, AF017763, AF017764, AF017765, AF017766, AF017767, AF017768, AF017769, AF017770, AF017771, AF017772, AF017773, AF017774, AF017775 Genomic DNA. Translation: AAC68835.1.
AF047492 mRNA. Translation: AAC03789.2.
AL356962, AL392166 Genomic DNA. Translation: CAC36327.2.
AL392166, AL356962 Genomic DNA. Translation: CAI41298.1.
CH471051 Genomic DNA. Translation: EAW48726.1.
BC117450 mRNA. Translation: AAI17451.1.
BC117452 mRNA. Translation: AAI17453.1.
CCDSiCCDS4985.1.
RefSeqiNP_001269297.1. NM_001282368.1.
NP_001554.2. NM_001563.3.
UniGeneiHs.590893.

Genome annotation databases

EnsembliENST00000369950; ENSP00000358966; ENSG00000112706.
GeneIDi3617.
KEGGihsa:3617.
UCSCiuc003pik.1. human.

Polymorphism databases

DMDMi115502232.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017776
, AF017760 , AF017761 , AF017762 , AF017763 , AF017764 , AF017765 , AF017766 , AF017767 , AF017768 , AF017769 , AF017770 , AF017771 , AF017772 , AF017773 , AF017774 , AF017775 Genomic DNA. Translation: AAC68835.1 .
AF047492 mRNA. Translation: AAC03789.2 .
AL356962 , AL392166 Genomic DNA. Translation: CAC36327.2 .
AL392166 , AL356962 Genomic DNA. Translation: CAI41298.1 .
CH471051 Genomic DNA. Translation: EAW48726.1 .
BC117450 mRNA. Translation: AAI17451.1 .
BC117452 mRNA. Translation: AAI17453.1 .
CCDSi CCDS4985.1.
RefSeqi NP_001269297.1. NM_001282368.1.
NP_001554.2. NM_001563.3.
UniGenei Hs.590893.

3D structure databases

ProteinModelPortali Q17R60.
SMRi Q17R60. Positions 576-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109830. 1 interaction.
STRINGi 9606.ENSP00000358966.

PTM databases

PhosphoSitei Q17R60.

Polymorphism databases

DMDMi 115502232.

Proteomic databases

PaxDbi Q17R60.
PRIDEi Q17R60.

Protocols and materials databases

DNASUi 3617.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369950 ; ENSP00000358966 ; ENSG00000112706 .
GeneIDi 3617.
KEGGi hsa:3617.
UCSCi uc003pik.1. human.

Organism-specific databases

CTDi 3617.
GeneCardsi GC06M076687.
HGNCi HGNC:6055. IMPG1.
MIMi 602870. gene.
neXtProti NX_Q17R60.
Orphaneti 99000. Adult-onset foveomacular vitelliform dystrophy.
PharmGKBi PA29865.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73774.
HOGENOMi HOG000113063.
HOVERGENi HBG081793.
InParanoidi Q17R60.
OMAi QMQKVFK.
OrthoDBi EOG7TXKFR.
PhylomeDBi Q17R60.
TreeFami TF331340.

Miscellaneous databases

GeneWikii IMPG1.
GenomeRNAii 3617.
NextBioi 14149.
PROi Q17R60.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q17R60.
Bgeei Q17R60.
CleanExi HS_IMPG1.
Genevestigatori Q17R60.

Family and domain databases

Gene3Di 3.30.70.960. 2 hits.
InterProi IPR000742. EG-like_dom.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 2 hits.
[Graphical view ]
SMARTi SM00200. SEA. 2 hits.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 2 hits.
PROSITEi PS50024. SEA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies."
    Felbor U., Gehrig A., Sauer C.G., Marquardt A., Koehler M., Schmid M., Weber B.H.F.
    Cytogenet. Cell Genet. 81:12-17(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan."
    Kuehn M.H., Hageman G.S.
    Matrix Biol. 18:509-518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 71-90, TISSUE SPECIFICITY.
    Tissue: Retina.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-518 AND TRP-704.
    Tissue: Brain.
  6. "SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan."
    Acharya S., Rodriguez I.R., Moreira E.F., Midura R.J., Misono K., Todres E., Hollyfield J.G.
    J. Biol. Chem. 273:31599-31606(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 71-79; 101-111; 249-265 AND 622-629, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis."
    Acharya S., Rayborn M.E., Hollyfield J.G.
    Glycobiology 8:997-1006(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.

Entry informationi

Entry nameiIMPG1_HUMAN
AccessioniPrimary (citable) accession number: Q17R60
Secondary accession number(s): A6NNZ6
, O43686, O95094, Q9BWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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