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Protein

Transcription factor Dp-1

Gene

TFDP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi113 – 19583Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-113510. E2F mediated regulation of DNA replication.
R-BTA-1538133. G0 and Early G1.
R-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-BTA-69205. G1/S-Specific Transcription.
R-BTA-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Dp-1
Gene namesi
Name:TFDP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Transcription factor Dp-1PRO_0000305939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31N6-acetyllysineBy similarity
Modified residuei23 – 231Phosphoserine; by CDK2Sequence analysisBy similarity

Post-translational modificationi

Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ17QZ4.
PRIDEiQ17QZ4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019645.

Interactioni

Subunit structurei

Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026175.

Structurei

3D structure databases

ProteinModelPortaliQ17QZ4.
SMRiQ17QZ4. Positions 113-195, 199-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 12723Interaction with CEBPABy similarityAdd
BLAST
Regioni204 – 27774DimerizationSequence analysisAdd
BLAST
Regioni211 – 327117Enhances binding of RB protein to E2FAdd
BLAST
Regioni214 – 24633DCB1Add
BLAST
Regioni259 – 31557DCB2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi161 – 19535DEF boxAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi250 – 2534Poly-Pro
Compositional biasi394 – 41017Asp/Glu-rich (acidic; NCB domain)Add
BLAST

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2829. Eukaryota.
ENOG410Y9QP. LUCA.
GeneTreeiENSGT00390000018222.
HOGENOMiHOG000030696.
HOVERGENiHBG009894.
InParanoidiQ17QZ4.
KOiK04683.
OMAiHPSTVNT.
OrthoDBiEOG091G0AVY.
TreeFamiTF314396.

Family and domain databases

CDDicd14458. DP_DD. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR028313. DP-1.
IPR003316. E2F_WHTH_DNA-bd_dom.
IPR014889. Transc_factor_DP_C.
IPR015648. Transcrpt_fac_DP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12548. PTHR12548. 1 hit.
PTHR12548:SF4. PTHR12548:SF4. 1 hit.
PfamiPF08781. DP. 1 hit.
PF02319. E2F_TDP. 1 hit.
[Graphical view]
PIRSFiPIRSF009404. Transcription_factor_DP. 1 hit.
SMARTiSM01138. DP. 1 hit.
SM01372. E2F_TDP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17QZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDAGLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN SLGKQLLPKT
60 70 80 90 100
FGQSNVNITQ QVVIGTPQRP AAPNTIVVGS PHTPNTHFVS QNQPSDPSPW
110 120 130 140 150
SAGKRNRKGE KNGKGLRHFS MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD
160 170 180 190 200
SHILPSESAY DQKNIRRRVY DALNVLMAMN IISKEKKEIK WIGLPTNSAQ
210 220 230 240 250
ECQSLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN RQVEQQASRP
260 270 280 290 300
PPPNSVIHLP FIIVNTSKKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL
310 320 330 340 350
KRMGMACGLE SGSCSPEDLR VARSLVPKAL EPYVTEMAQG SLGGVFVASA
360 370 380 390 400
VSTSNGTRLS ASDLANGADG ALATSSSGSQ YSGSRVETPV SCVGEDDEDD
410
EDFNENEEED
Length:410
Mass (Da):44,926
Last modified:July 25, 2006 - v1
Checksum:iA8D2A37139EB7997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118103 mRNA. Translation: AAI18104.1.
RefSeqiNP_001069497.1. NM_001076029.1.
UniGeneiBt.3383.

Genome annotation databases

EnsembliENSBTAT00000026175; ENSBTAP00000026175; ENSBTAG00000019645.
GeneIDi534579.
KEGGibta:534579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118103 mRNA. Translation: AAI18104.1.
RefSeqiNP_001069497.1. NM_001076029.1.
UniGeneiBt.3383.

3D structure databases

ProteinModelPortaliQ17QZ4.
SMRiQ17QZ4. Positions 113-195, 199-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026175.

Proteomic databases

PaxDbiQ17QZ4.
PRIDEiQ17QZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026175; ENSBTAP00000026175; ENSBTAG00000019645.
GeneIDi534579.
KEGGibta:534579.

Organism-specific databases

CTDi7027.

Phylogenomic databases

eggNOGiKOG2829. Eukaryota.
ENOG410Y9QP. LUCA.
GeneTreeiENSGT00390000018222.
HOGENOMiHOG000030696.
HOVERGENiHBG009894.
InParanoidiQ17QZ4.
KOiK04683.
OMAiHPSTVNT.
OrthoDBiEOG091G0AVY.
TreeFamiTF314396.

Enzyme and pathway databases

ReactomeiR-BTA-113510. E2F mediated regulation of DNA replication.
R-BTA-1538133. G0 and Early G1.
R-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-BTA-69205. G1/S-Specific Transcription.
R-BTA-69231. Cyclin D associated events in G1.

Gene expression databases

BgeeiENSBTAG00000019645.

Family and domain databases

CDDicd14458. DP_DD. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR028313. DP-1.
IPR003316. E2F_WHTH_DNA-bd_dom.
IPR014889. Transc_factor_DP_C.
IPR015648. Transcrpt_fac_DP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12548. PTHR12548. 1 hit.
PTHR12548:SF4. PTHR12548:SF4. 1 hit.
PfamiPF08781. DP. 1 hit.
PF02319. E2F_TDP. 1 hit.
[Graphical view]
PIRSFiPIRSF009404. Transcription_factor_DP. 1 hit.
SMARTiSM01138. DP. 1 hit.
SM01372. E2F_TDP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTFDP1_BOVIN
AccessioniPrimary (citable) accession number: Q17QZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.