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Protein

Serine/threonine-protein kinase 40

Gene

STK40

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ATPPROSITE-ProRule annotation1
Active sitei197Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 49ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 40 (EC:2.7.11.1)
Gene namesi
Name:STK40
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522601 – 436Serine/threonine-protein kinase 40Add BLAST436

Proteomic databases

PaxDbiQ17QV9.
PRIDEiQ17QV9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015969.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021243.

Structurei

3D structure databases

ProteinModelPortaliQ17QV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 332Protein kinasePROSITE-ProRule annotationAdd BLAST298

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ17QV9.
KOiK16312.
OMAiGNIPPVR.
OrthoDBiEOG091G0AGV.
TreeFamiTF329785.

Family and domain databases

CDDicd13974. STKc_SHIK. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF16. PTHR22961:SF16. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRASDRGA GETSARAKAL GSGISGNNAK RAGPFILGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGDQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEV VEDAESNRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNVVHRDLKL
210 220 230 240 250
GNMVLSKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSS IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSNADS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SVHEARSWVP
410 420 430
KRQSGAGVPP VRRLGHDAQP VNPLDAAILA QRYLRK
Length:436
Mass (Da):48,929
Last modified:July 25, 2006 - v1
Checksum:i56DDF51AD14695AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118150 mRNA. Translation: AAI18151.1.
RefSeqiNP_001069195.1. NM_001075727.1.
XP_005204789.1. XM_005204732.3.
XP_010801923.1. XM_010803621.2.
XP_010801924.1. XM_010803622.1.
XP_015321756.1. XM_015466270.1.
UniGeneiBt.31357.

Genome annotation databases

EnsembliENSBTAT00000021243; ENSBTAP00000021243; ENSBTAG00000015969.
GeneIDi515723.
KEGGibta:515723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118150 mRNA. Translation: AAI18151.1.
RefSeqiNP_001069195.1. NM_001075727.1.
XP_005204789.1. XM_005204732.3.
XP_010801923.1. XM_010803621.2.
XP_010801924.1. XM_010803622.1.
XP_015321756.1. XM_015466270.1.
UniGeneiBt.31357.

3D structure databases

ProteinModelPortaliQ17QV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021243.

Proteomic databases

PaxDbiQ17QV9.
PRIDEiQ17QV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021243; ENSBTAP00000021243; ENSBTAG00000015969.
GeneIDi515723.
KEGGibta:515723.

Organism-specific databases

CTDi83931.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000007322.
HOVERGENiHBG080296.
InParanoidiQ17QV9.
KOiK16312.
OMAiGNIPPVR.
OrthoDBiEOG091G0AGV.
TreeFamiTF329785.

Gene expression databases

BgeeiENSBTAG00000015969.

Family and domain databases

CDDicd13974. STKc_SHIK. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024236. Ser/Thr_kinase_40.
IPR008271. Ser/Thr_kinase_AS.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF16. PTHR22961:SF16. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK40_BOVIN
AccessioniPrimary (citable) accession number: Q17QV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.