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Protein

Serine/threonine-protein kinase 40

Gene

STK40

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ATPPROSITE-ProRule annotation1
Active sitei197Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 49ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 40 (EC:2.7.11.1)
Gene namesi
Name:STK40
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:35402 STK40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522601 – 436Serine/threonine-protein kinase 40Add BLAST436

Proteomic databases

PaxDbiQ17QV9
PRIDEiQ17QV9

Expressioni

Gene expression databases

BgeeiENSBTAG00000015969

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021243

Structurei

3D structure databases

ProteinModelPortaliQ17QV9
SMRiQ17QV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 332Protein kinasePROSITE-ProRule annotationAdd BLAST298

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140868
HOGENOMiHOG000007322
HOVERGENiHBG080296
InParanoidiQ17QV9
KOiK16312
OMAiPFILGPR
OrthoDBiEOG091G0AGV
TreeFamiTF329785

Family and domain databases

CDDicd13974 STKc_SHIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR024236 Ser/Thr_kinase_40
IPR008271 Ser/Thr_kinase_AS
IPR024104 Tribbles/Ser_Thr_kinase_40
PANTHERiPTHR22961 PTHR22961, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRASDRGA GETSARAKAL GSGISGNNAK RAGPFILGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGDQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEV VEDAESNRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNVVHRDLKL
210 220 230 240 250
GNMVLSKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSS IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSNADS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SVHEARSWVP
410 420 430
KRQSGAGVPP VRRLGHDAQP VNPLDAAILA QRYLRK
Length:436
Mass (Da):48,929
Last modified:July 25, 2006 - v1
Checksum:i56DDF51AD14695AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118150 mRNA Translation: AAI18151.1
RefSeqiNP_001069195.1, NM_001075727.1
XP_005204789.1, XM_005204732.3
XP_010801923.1, XM_010803621.2
XP_010801924.1, XM_010803622.1
XP_015321756.1, XM_015466270.1
UniGeneiBt.31357

Genome annotation databases

EnsembliENSBTAT00000021243; ENSBTAP00000021243; ENSBTAG00000015969
GeneIDi515723
KEGGibta:515723

Similar proteinsi

Entry informationi

Entry nameiSTK40_BOVIN
AccessioniPrimary (citable) accession number: Q17QV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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