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Protein

Thiopurine S-methyltransferase

Gene

TPMT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Binding sitei69S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei90S-adenosyl-L-methionineBy similarity1
Binding sitei152S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-BTA-156581 Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferase (EC:2.1.1.67)
Alternative name(s):
Thiopurine methyltransferase
Gene namesi
Name:TPMT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:36255 TPMT

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786601 – 245Thiopurine S-methyltransferaseAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ17QQ2
PeptideAtlasiQ17QQ2
PRIDEiQ17QQ2

Expressioni

Gene expression databases

BgeeiENSBTAG00000019300

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025698

Structurei

3D structure databases

ProteinModelPortaliQ17QQ2
SMRiQ17QQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 40S-adenosyl-L-methionine bindingBy similarityAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGTR Eukaryota
ENOG4111GNF LUCA
GeneTreeiENSGT00390000016823
HOGENOMiHOG000276919
HOVERGENiHBG003037
InParanoidiQ17QQ2
KOiK00569
OMAiMKWFADR
OrthoDBiEOG091G0VS2
TreeFamiTF328951

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDSRALLDS EEYPNTEAQK DRVLTLEEWQ EKWVNHKTGF HQEQGHQLLK
60 70 80 90 100
KYLDTFLKGE KALRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIRDFF
110 120 130 140 150
TEQNLSYSEE PIMEIPGAKI FKSSSGNISL YCCNLFDLPR ANIGKFDRIW
160 170 180 190 200
DRGALVAVNP SDRKRYSDVM LSLTRPGFRY LLSVFSYDPT KHAGPPFYVT
210 220 230 240
DGEVKKLFGS VCNIQCLEKV DVFEERHKSW GIDQIIERLY LFTEK
Length:245
Mass (Da):28,335
Last modified:July 25, 2006 - v1
Checksum:iC734333BEEC2828F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118238 mRNA Translation: AAI18239.1
RefSeqiNP_001068999.1, NM_001075531.1
XP_005223808.1, XM_005223751.3
XP_005223809.1, XM_005223752.3
XP_005223811.1, XM_005223754.3
UniGeneiBt.15903

Genome annotation databases

EnsembliENSBTAT00000025698; ENSBTAP00000025698; ENSBTAG00000019300
GeneIDi511644
KEGGibta:511644

Similar proteinsi

Entry informationi

Entry nameiTPMT_BOVIN
AccessioniPrimary (citable) accession number: Q17QQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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