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Q17QM8

- DUS14_BOVIN

UniProt

Q17QM8 - DUS14_BOVIN

Protein

Dual specificity protein phosphatase 14

Gene

DUSP14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP14
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Dual specificity protein phosphatase 14PRO_0000283054Add
    BLAST

    Proteomic databases

    PRIDEiQ17QM8.

    Interactioni

    Subunit structurei

    Interacts with CD28.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17QM8.
    SMRiQ17QM8. Positions 26-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 15666Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117525.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ17QM8.
    KOiK14165.
    OMAiYLMKFHS.
    OrthoDBiEOG7PK90H.
    TreeFamiTF316009.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17QM8-1 [UniParc]FASTAAdd to Basket

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    MSSRGHSTLP RTLMAPRMIS EGDLGGIAQI TSSLFLGRGS VASNRHLLQA    50
    RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV 100
    SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP 150
    NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLLPYWGI 198
    Length:198
    Mass (Da):22,237
    Last modified:July 25, 2006 - v1
    Checksum:i1FAAADC68CF8FDBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118267 mRNA. Translation: AAI18268.1.
    RefSeqiNP_001068776.1. NM_001075308.1.
    XP_005220051.1. XM_005219994.1.
    UniGeneiBt.20043.

    Genome annotation databases

    EnsembliENSBTAT00000013570; ENSBTAP00000013570; ENSBTAG00000010279.
    GeneIDi507294.
    KEGGibta:507294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118267 mRNA. Translation: AAI18268.1 .
    RefSeqi NP_001068776.1. NM_001075308.1.
    XP_005220051.1. XM_005219994.1.
    UniGenei Bt.20043.

    3D structure databases

    ProteinModelPortali Q17QM8.
    SMRi Q17QM8. Positions 26-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013570.

    Proteomic databases

    PRIDEi Q17QM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013570 ; ENSBTAP00000013570 ; ENSBTAG00000010279 .
    GeneIDi 507294.
    KEGGi bta:507294.

    Organism-specific databases

    CTDi 11072.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117525.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q17QM8.
    KOi K14165.
    OMAi YLMKFHS.
    OrthoDBi EOG7PK90H.
    TreeFami TF316009.

    Miscellaneous databases

    NextBioi 20867993.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiDUS14_BOVIN
    AccessioniPrimary (citable) accession number: Q17QM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3