Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q17QM8 (DUS14_BOVIN)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein phosphatase 14
    EC=3.1.3.48
    EC=3.1.3.16
Gene names
Name: DUSP14
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Subunit structure

Interacts with CD28 By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Dual specificity protein phosphatase 14
PRO_0000283054

Regions

Domain91 – 15666Tyrosine-protein phosphatase

Sites

Active site1111Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue71Phosphoserine By similarity
Modified residue81Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17QM8-1 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 1FAAADC68CF8FDBE

FASTA19822,237
        10         20         30         40         50         60 
MSSRGHSTLP RTLMAPRMIS EGDLGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT 

        70         80         90        100        110        120 
IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT 

       130        140        150        160        170        180 
LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI 

       190 
VPDVYEKESR HLLPYWGI 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118267 mRNA. Translation: AAI18268.1.
IPIIPI00703291.
RefSeqNP_001068776.1.
UniGeneBt.20043

3D structure databases

SMRQ17QM8. Positions 26-186.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAT00000013570; ENSBTAP00000013570; ENSBTAG00000010279; Bos taurus. [Genome view]
GeneID507294.
KEGGbta:507294.

Organism-specific databases

CTD507294.

Phylogenomic databases

eggNOGmaNOG07777.
HOVERGENQ17QM8.
InParanoidQ17QM8.
OMAPYGVVPD.
OrthoDBEOG90043R.
PhylomeDBQ17QM8.

Enzyme and pathway databases

BRENDA3.1.3.16. 251.
3.1.3.48. 251.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020420. Dual-sp_phosphatase_famB.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUS14_BOVIN
AccessionPrimary (citable) accession number: Q17QM8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 25, 2006
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents