Reviewed, UniProtKB/Swiss-Prot Q17QM8 (DUS14_BOVIN)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 14
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

DUSP14

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with CD28 By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Dual specificity protein phosphatase 14		PRO_0000283054
Regions
	Domain	91 – 156	66	Tyrosine-protein phosphatase
Sites
	Active site	111	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	7	1	Phosphoserine By similarity
	Modified residue	8	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17QM8-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 1FAAADC68CF8FDBE	FASTA	198	22,237
	10 20 30 40 50 60 MSSRGHSTLP RTLMAPRMIS EGDLGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT 70 80 90 100 110 120 IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT 130 140 150 160 170 180 LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI 190 VPDVYEKESR HLLPYWGI

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Basal ganglia.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118267 mRNA. Translation: AAI18268.1.
IPI	IPI00703291.
RefSeq	NP_001068776.1.
UniGene	Bt.20043
3D structure databases
SMR	Q17QM8. Positions 26-186.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000013570; ENSBTAP00000013570; ENSBTAG00000010279; Bos taurus. [Genome view]
GeneID	507294.
KEGG	bta:507294.
Organism-specific databases
CTD	507294.
Phylogenomic databases
eggNOG	maNOG07777.
HOVERGEN	Q17QM8.
InParanoid	Q17QM8.
OMA	PYGVVPD.
OrthoDB	EOG90043R.
PhylomeDB	Q17QM8.
Enzyme and pathway databases
BRENDA	3.1.3.16. 251. 3.1.3.48. 251.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020420. Dual-sp_phosphatase_famB. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01910. ADSPHPHTASEB.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS14_BOVIN

Accession

Primary (citable) accession number: Q17QM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	July 25, 2006
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)