SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q17QM8

- DUS14_BOVIN

UniProt

Q17QM8 - DUS14_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Dual specificity protein phosphatase 14
Gene
DUSP14
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
  3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Dual specificity protein phosphatase 14
PRO_0000283054Add
BLAST

Proteomic databases

PRIDEiQ17QM8.

Interactioni

Subunit structurei

Interacts with CD28 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013570.

Structurei

3D structure databases

ProteinModelPortaliQ17QM8.
SMRiQ17QM8. Positions 26-186.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 15666Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00750000117525.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ17QM8.
KOiK14165.
OMAiYLMKFHS.
OrthoDBiEOG7PK90H.
TreeFamiTF316009.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QM8-1 [UniParc]FASTAAdd to Basket

« Hide

MSSRGHSTLP RTLMAPRMIS EGDLGGIAQI TSSLFLGRGS VASNRHLLQA    50
RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV 100
SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP 150
NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLLPYWGI 198
Length:198
Mass (Da):22,237
Last modified:July 25, 2006 - v1
Checksum:i1FAAADC68CF8FDBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118267 mRNA. Translation: AAI18268.1.
RefSeqiNP_001068776.1. NM_001075308.1.
XP_005220051.1. XM_005219994.1.
UniGeneiBt.20043.

Genome annotation databases

EnsembliENSBTAT00000013570; ENSBTAP00000013570; ENSBTAG00000010279.
GeneIDi507294.
KEGGibta:507294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118267 mRNA. Translation: AAI18268.1 .
RefSeqi NP_001068776.1. NM_001075308.1.
XP_005220051.1. XM_005219994.1.
UniGenei Bt.20043.

3D structure databases

ProteinModelPortali Q17QM8.
SMRi Q17QM8. Positions 26-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000013570.

Proteomic databases

PRIDEi Q17QM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013570 ; ENSBTAP00000013570 ; ENSBTAG00000010279 .
GeneIDi 507294.
KEGGi bta:507294.

Organism-specific databases

CTDi 11072.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00750000117525.
HOGENOMi HOG000233766.
HOVERGENi HBG051422.
InParanoidi Q17QM8.
KOi K14165.
OMAi YLMKFHS.
OrthoDBi EOG7PK90H.
TreeFami TF316009.

Miscellaneous databases

NextBioi 20867993.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiDUS14_BOVIN
AccessioniPrimary (citable) accession number: Q17QM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi