Q17QM4 (EPT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ethanolaminephosphotransferase 1
EC=2.7.8.1

Alternative name(s):
Selenoprotein I
Short name=SelI

Gene names

Name:	EPT1
Synonyms:	SELI

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway By similarity.
Catalytic activity	CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.
Cofactor	Magnesium or manganese By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Sequence caution	The sequence AAI18274.1 differs from that shown. Reason: Erroneous termination at position 387. Translated as Sec.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Membrane
Coding sequence diversity	Selenocysteine
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium Manganese Metal-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ethanolaminephosphotransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Ethanolaminephosphotransferase 1		PRO_0000289258
Regions
	Transmembrane	47 – 69	23	Helical; Potential
	Transmembrane	84 – 103	20	Helical; Potential
	Transmembrane	123 – 145	23	Helical; Potential
	Transmembrane	150 – 172	23	Helical; Potential
	Transmembrane	179 – 201	23	Helical; Potential
	Transmembrane	221 – 243	23	Helical; Potential
	Transmembrane	256 – 278	23	Helical; Potential
	Transmembrane	291 – 310	20	Helical; Potential
	Transmembrane	317 – 339	23	Helical; Potential
	Transmembrane	344 – 366	23	Helical; Potential
Amino acid modifications
	Non-standard residue	387	1	Selenocysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17QM4 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: A393118B091D26F3	FASTA	397	45,214
	10 20 30 40 50 60 MASYEYVSPE QLAGFDKYKY SAVDTNPLSL YVMHPFWNTV VKVFPTWLAP NLITFSGFLL 70 80 90 100 110 120 VVFNFLLLAY FDPDFYASAP GHKHVPDWVW IVVGILNFMA YTLDGVDGKQ ARRTNSSTPL 130 140 150 160 170 180 GELFDHGLDS WSCVYFVVTV YSIFGRGSSG VSVFVLYLLL WVVLFSFILS HWEKYNTGIL 190 200 210 220 230 240 FLPWGYDISQ VTISFVYIVT AVVGVEAWYE PFLFNFLYRD LFTAMIFGCA LCVTLPMSLL 250 260 270 280 290 300 NFFRSYKNNT LKHNSVYEAV VPFFSPCLLF ILSTAWILLS PSDILELHPR VFYLMVGTAF 310 320 330 340 350 360 ANSTCQLIVC QMSSTRCPTL NWLLLPLFVI VMVVNVGVTP YVESILLFTL TAAFTLAHIH 370 380 390 YGVRVVKQLS NHFHIYPFSL RKPNSDULGV EEKNIGL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118273 mRNA. Translation: AAI18274.1. Sequence problems.
IPI	IPI00693891.
RefSeq	NP_001068725.2. NM_001075257.1.
UniGene	Bt.20819.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000010310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000010310; ENSBTAP00000010310; ENSBTAG00000007837.
GeneID	506381.
KEGG	bta:506381.
Organism-specific databases
CTD	85465.
Phylogenomic databases
eggNOG	COG5050.
GeneTree	ENSGT00530000063048.
HOVERGEN	HBG044519.
InParanoid	Q17QM4.
KO	K00993.
OrthoDB	EOG4FFD23.
Enzyme and pathway databases
UniPathway	UPA00558; UER00743.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR014472. CHOPT. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF015665. CHOPT. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20867584.

Entry information

Entry name

EPT1_BOVIN

Accession

Primary (citable) accession number: Q17QM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program