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Q17QK9

- NAA60_BOVIN

UniProt

Q17QK9 - NAA60_BOVIN

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Protein

N-alpha-acetyltransferase 60

Gene

NAA60

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. chromosome segregation Source: UniProtKB
  3. histone H4 acetylation Source: UniProtKB
  4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:NAA60
Synonyms:NAT15
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791N6-acetyllysine; by autocatalysisBy similarity
Modified residuei105 – 1051N6-acetyllysine; by autocatalysisBy similarity
Modified residuei109 – 1091N6-acetyllysine; by autocatalysisBy similarity
Modified residuei121 – 1211N6-acetyllysine; by autocatalysisBy similarity
Modified residuei156 – 1561N6-acetyllysine; by autocatalysisBy similarity

Post-translational modificationi

Acetylated: autoacetylation is required for optimal acetyltransferase activity.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ17QK9.

Expressioni

Gene expression databases

ExpressionAtlasiQ17QK9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006410.

Structurei

3D structure databases

ProteinModelPortaliQ17QK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiQ17QK9.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEAVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK
60 70 80 90 100
KFFSLAATYR GDIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS
110 120 130 140 150
LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAISFY
160 170 180 190 200
ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA
210 220 230 240
LANLSPCSIP HRIYRQAQSL LCSFLPWSSI STKGGIEYSR TM
Length:242
Mass (Da):27,459
Last modified:July 25, 2006 - v1
Checksum:iE2E25F6BA8B13683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118298 mRNA. Translation: AAI18299.1.
RefSeqiNP_001069117.1. NM_001075649.1.
XP_005224493.1. XM_005224436.1.
UniGeneiBt.9071.

Genome annotation databases

EnsembliENSBTAT00000006410; ENSBTAP00000006410; ENSBTAG00000004875.
GeneIDi514154.
KEGGibta:514154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118298 mRNA. Translation: AAI18299.1 .
RefSeqi NP_001069117.1. NM_001075649.1.
XP_005224493.1. XM_005224436.1.
UniGenei Bt.9071.

3D structure databases

ProteinModelPortali Q17QK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000006410.

Proteomic databases

PRIDEi Q17QK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006410 ; ENSBTAP00000006410 ; ENSBTAG00000004875 .
GeneIDi 514154.
KEGGi bta:514154.

Organism-specific databases

CTDi 79903.

Phylogenomic databases

eggNOGi NOG276305.
GeneTreei ENSGT00390000008314.
HOGENOMi HOG000280717.
HOVERGENi HBG061680.
InParanoidi Q17QK9.
OMAi TVKQLCG.
OrthoDBi EOG7M0NT7.
TreeFami TF323980.

Miscellaneous databases

NextBioi 20871196.

Gene expression databases

ExpressionAtlasi Q17QK9. baseline.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiNAA60_BOVIN
AccessioniPrimary (citable) accession number: Q17QK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3