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Q17QK9 (NAA60_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 60

EC=2.3.1.48
EC=2.3.1.88
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene names
Name:NAA60
Synonyms:NAT15
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activity

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Golgi apparatus membrane By similarity.

Post-translational modification

Acetylated: autoacetylation is required for optimal acetyltransferase activity By similarity.

Sequence similarities

Belongs to the acetyltransferase family. NAA60 subfamily.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242N-alpha-acetyltransferase 60
PRO_0000321565

Regions

Domain13 – 182170N-acetyltransferase

Amino acid modifications

Modified residue791N6-acetyllysine; by autocatalysis By similarity
Modified residue1051N6-acetyllysine; by autocatalysis By similarity
Modified residue1091N6-acetyllysine; by autocatalysis By similarity
Modified residue1211N6-acetyllysine; by autocatalysis By similarity
Modified residue1561N6-acetyllysine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17QK9 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: E2E25F6BA8B13683

FASTA24227,459
        10         20         30         40         50         60 
MTEAVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK KFFSLAATYR 

        70         80         90        100        110        120 
GDIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS LGVVKEFRKH GIGSLLLESL 

       130        140        150        160        170        180 
KDHISTTAQD HCKAIYLHVL TTNNTAISFY ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY 

       190        200        210        220        230        240 
INGGHPPWTI LDYIQHLGSA LANLSPCSIP HRIYRQAQSL LCSFLPWSSI STKGGIEYSR 


TM 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118298 mRNA. Translation: AAI18299.1.
RefSeqNP_001069117.1. NM_001075649.1.
XP_005224493.1. XM_005224436.1.
UniGeneBt.9071.

3D structure databases

ProteinModelPortalQ17QK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000006410.

Proteomic databases

PRIDEQ17QK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000006410; ENSBTAP00000006410; ENSBTAG00000004875.
GeneID514154.
KEGGbta:514154.

Organism-specific databases

CTD79903.

Phylogenomic databases

eggNOGNOG276305.
GeneTreeENSGT00390000008314.
HOGENOMHOG000280717.
HOVERGENHBG061680.
InParanoidQ17QK9.
OMATVKQLCG.
OrthoDBEOG7M0NT7.
TreeFamTF323980.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871196.

Entry information

Entry nameNAA60_BOVIN
AccessionPrimary (citable) accession number: Q17QK9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families