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Q17QK9

- NAA60_BOVIN

UniProt

Q17QK9 - NAA60_BOVIN

Protein

N-alpha-acetyltransferase 60

Gene

NAA60

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: UniProtKB
    2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. chromosome segregation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
    5. nucleosome assembly Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
    Alternative name(s):
    N-acetyltransferase 15
    NatF catalytic subunit
    Gene namesi
    Name:NAA60
    Synonyms:NAT15
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei105 – 1051N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei109 – 1091N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei121 – 1211N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei156 – 1561N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Acetylated: autoacetylation is required for optimal acetyltransferase activity.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ17QK9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000006410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17QK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276305.
    GeneTreeiENSGT00390000008314.
    HOGENOMiHOG000280717.
    HOVERGENiHBG061680.
    InParanoidiQ17QK9.
    OMAiTVKQLCG.
    OrthoDBiEOG7M0NT7.
    TreeFamiTF323980.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17QK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK    50
    KFFSLAATYR GDIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS 100
    LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAISFY 150
    ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA 200
    LANLSPCSIP HRIYRQAQSL LCSFLPWSSI STKGGIEYSR TM 242
    Length:242
    Mass (Da):27,459
    Last modified:July 25, 2006 - v1
    Checksum:iE2E25F6BA8B13683
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118298 mRNA. Translation: AAI18299.1.
    RefSeqiNP_001069117.1. NM_001075649.1.
    XP_005224493.1. XM_005224436.1.
    UniGeneiBt.9071.

    Genome annotation databases

    EnsembliENSBTAT00000006410; ENSBTAP00000006410; ENSBTAG00000004875.
    GeneIDi514154.
    KEGGibta:514154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118298 mRNA. Translation: AAI18299.1 .
    RefSeqi NP_001069117.1. NM_001075649.1.
    XP_005224493.1. XM_005224436.1.
    UniGenei Bt.9071.

    3D structure databases

    ProteinModelPortali Q17QK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000006410.

    Proteomic databases

    PRIDEi Q17QK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006410 ; ENSBTAP00000006410 ; ENSBTAG00000004875 .
    GeneIDi 514154.
    KEGGi bta:514154.

    Organism-specific databases

    CTDi 79903.

    Phylogenomic databases

    eggNOGi NOG276305.
    GeneTreei ENSGT00390000008314.
    HOGENOMi HOG000280717.
    HOVERGENi HBG061680.
    InParanoidi Q17QK9.
    OMAi TVKQLCG.
    OrthoDBi EOG7M0NT7.
    TreeFami TF323980.

    Miscellaneous databases

    NextBioi 20871196.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiNAA60_BOVIN
    AccessioniPrimary (citable) accession number: Q17QK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3