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Q17QK8 (SPRE_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sepiapterin reductase
Short name=SPR
EC=1.1.1.153
Gene names
Name:SPR
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin By similarity.

Catalytic activity

7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH.

Tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the sepiapterin reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtetrahydrobiopterin biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

sepiapterin reductase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Sepiapterin reductase
PRO_0000327641

Regions

Nucleotide binding20 – 267NADP By similarity
Nucleotide binding48 – 492NADP By similarity
Nucleotide binding75 – 762NADP By similarity
Nucleotide binding207 – 2126NADP By similarity
Region163 – 1642Substrate binding By similarity

Sites

Binding site1761Substrate By similarity
Binding site1801NADP By similarity
Binding site2051Substrate; via amide nitrogen By similarity
Binding site2631Substrate By similarity

Experimental info

Sequence conflict2361E → Q in ABI79460. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q17QK8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 4F2B7089A40F8C52

FASTA26728,939
        10         20         30         40         50         60 
MEGSVGKVGG LGRTLCVLTG ASRGFGRTLA QVLAPLMSPR SVLVLSARND EALRQLETEL 

        70         80         90        100        110        120 
GAEWPGLRIV RVPADLGAET GLQQLVGALC DLPRPEGLQR VLLINNAGTL GDVSKRWVDL 

       130        140        150        160        170        180 
TDPTEVNNYW TLNLTSTLCL TSSILQAFPD SPGLSRTVVN ISSICALQPF KGWGLYCAGK 

       190        200        210        220        230        240 
AARNMMFQVL AAEEPSVRVL SYGPGPLDTD MQQLARETSV DPDLRKSLQE LKRKGELVDC 

       250        260 
KISAQKLLSL LQNDKFESGA HIDFYDE

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of cDNA encoding bovine sepiapterin reductase isoform 2."
Pung Y.F., Cai H.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ978331 mRNA. Translation: ABI79460.1.
BC118299 mRNA. Translation: AAI18300.1.
IPIIPI00709782.
RefSeqNP_001069471.1. NM_001076003.1.
UniGeneBt.3075.

3D structure databases

ProteinModelPortalQ17QK8.
SMRQ17QK8. Positions 11-267.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ17QK8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000029280; ENSBTAP00000029280; ENSBTAG00000021961.
GeneID533836.
KEGGbta:533836.

Organism-specific databases

CTD6697.

Phylogenomic databases

eggNOGmaNOG16096.
GeneTreeENSGT00440000033609.
HOVERGENHBG006973.
InParanoidQ17QK8.
OrthoDBEOG4HMJB9.
PhylomeDBQ17QK8.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR006393. Sepiapterin_red.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00072.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
TIGRFAMsTIGR01500. Sepiapter_red. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPRE_BOVIN
AccessionPrimary (citable) accession number: Q17QK8
Secondary accession number(s): A7YKV0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 25, 2006
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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