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Protein

F-box only protein 2

Gene

FBXO2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei174Important for carbohydrate bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandLectin

Enzyme and pathway databases

ReactomeiR-BTA-8951664 Neddylation
R-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 2
Gene namesi
Name:FBXO2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:28897 FBXO2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849771 – 297F-box only protein 2Add BLAST297

Proteomic databases

PaxDbiQ17QK6
PRIDEiQ17QK6

Expressioni

Gene expression databases

BgeeiENSBTAG00000007223
ExpressionAtlasiQ17QK6 baseline and differential

Interactioni

Subunit structurei

Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048374

Structurei

3D structure databases

ProteinModelPortaliQ17QK6
SMRiQ17QK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 92F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini114 – 297FBAPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 213Carbohydrate bindingBy similarity3
Regioni279 – 280Carbohydrate bindingBy similarity2

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ17QK6
KOiK10099

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDGDPESV GQPEEASPEE QQEEACAEEA NGGEERPEDD GEGEAAYLDE
60 70 80 90 100
LPEPLLLRVL AELPAAQLVQ ACRLVCLRWK ELVDGAPLWL LKCQQEGLVP
110 120 130 140 150
QDGPEDERDH WQQFYFLSKR RRNLLRNPCG EEDLEGWCDV EHGGDGWRVE
160 170 180 190 200
ELPGDCGVEF IHDESVKKYF ASSFEWCRKA QIIDLQAEGY WEELLDTTQP
210 220 230 240 250
AIVVKDWYSG RRDAGCLYEL TVKLLSEHED VLAEFNSGQV AVPADSDDGG
260 270 280 290
WTEISHTFTD YGPGVRFIRF EHGGQDCVYW KGWFGARVTN SSVWVEP
Length:297
Mass (Da):33,601
Last modified:July 25, 2006 - v1
Checksum:i218B1BDEB6DD8DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118302 mRNA Translation: AAI18303.1
RefSeqiNP_001069037.1, NM_001075569.1
UniGeneiBt.88141

Genome annotation databases

EnsembliENSBTAT00000009501; ENSBTAP00000009501; ENSBTAG00000007223
GeneIDi512589
KEGGibta:512589

Similar proteinsi

Entry informationi

Entry nameiFBX2_BOVIN
AccessioniPrimary (citable) accession number: Q17QK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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