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Protein

F-box only protein 2

Gene

FBXO2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei174 – 1741Important for carbohydrate bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 2
Gene namesi
Name:FBXO2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297F-box only protein 2PRO_0000284977Add
BLAST

Proteomic databases

PaxDbiQ17QK6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007223.
ExpressionAtlasiQ17QK6. baseline.

Interactioni

Subunit structurei

Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048374.

Structurei

3D structure databases

ProteinModelPortaliQ17QK6.
SMRiQ17QK6. Positions 58-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 9248F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini114 – 297184FBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2133Carbohydrate bindingBy similarity
Regioni279 – 2802Carbohydrate bindingBy similarity

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ17QK6.
KOiK10099.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDGDPESV GQPEEASPEE QQEEACAEEA NGGEERPEDD GEGEAAYLDE
60 70 80 90 100
LPEPLLLRVL AELPAAQLVQ ACRLVCLRWK ELVDGAPLWL LKCQQEGLVP
110 120 130 140 150
QDGPEDERDH WQQFYFLSKR RRNLLRNPCG EEDLEGWCDV EHGGDGWRVE
160 170 180 190 200
ELPGDCGVEF IHDESVKKYF ASSFEWCRKA QIIDLQAEGY WEELLDTTQP
210 220 230 240 250
AIVVKDWYSG RRDAGCLYEL TVKLLSEHED VLAEFNSGQV AVPADSDDGG
260 270 280 290
WTEISHTFTD YGPGVRFIRF EHGGQDCVYW KGWFGARVTN SSVWVEP
Length:297
Mass (Da):33,601
Last modified:July 25, 2006 - v1
Checksum:i218B1BDEB6DD8DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118302 mRNA. Translation: AAI18303.1.
RefSeqiNP_001069037.1. NM_001075569.1.
UniGeneiBt.88141.

Genome annotation databases

EnsembliENSBTAT00000009501; ENSBTAP00000009501; ENSBTAG00000007223.
GeneIDi512589.
KEGGibta:512589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118302 mRNA. Translation: AAI18303.1.
RefSeqiNP_001069037.1. NM_001075569.1.
UniGeneiBt.88141.

3D structure databases

ProteinModelPortaliQ17QK6.
SMRiQ17QK6. Positions 58-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048374.

Proteomic databases

PaxDbiQ17QK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009501; ENSBTAP00000009501; ENSBTAG00000007223.
GeneIDi512589.
KEGGibta:512589.

Organism-specific databases

CTDi26232.

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ17QK6.
KOiK10099.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSBTAG00000007223.
ExpressionAtlasiQ17QK6. baseline.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX2_BOVIN
AccessioniPrimary (citable) accession number: Q17QK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.