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Q17QJ3

- DUS26_BOVIN

UniProt

Q17QJ3 - DUS26_BOVIN

Protein

Dual specificity protein phosphatase 26

Gene

DUSP26

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP26
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 27

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292218Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with HSF4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ17QJ3.
    SMRiQ17QJ3. Positions 61-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 206146Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00550000074474.
    HOGENOMiHOG000233767.
    HOVERGENiHBG001524.
    InParanoidiQ17QJ3.
    KOiK14165.
    OMAiMAFMSRF.
    OrthoDBiEOG7CZK7N.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17QJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPGNWLWAS VTFMARFSRS GSRSPVRVRG ALEEPPAVQH PFLNVFELER    50
    LLYTGKTACN HADEVWPGLY LGDQEIANNH RELRRLGITH VLNASHSRWR 100
    GTPEAYEGLG IRYLGVEAHD SPAFDMSVHF QAAADFIHRA LSQPGGRILV 150
    HCAVGVSRSA TLVLAYLMLY HRLTLVEAIK KVKDHRGIIP NRGFLRQLLA 200
    LDRRLRQGLE A 211
    Length:211
    Mass (Da):23,767
    Last modified:July 25, 2006 - v1
    Checksum:i4A576DD55BF6770E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118329 mRNA. Translation: AAI18330.1.
    RefSeqiNP_001069472.1. NM_001076004.1.
    UniGeneiBt.23521.

    Genome annotation databases

    EnsembliENSBTAT00000021830; ENSBTAP00000021830; ENSBTAG00000016413.
    GeneIDi533896.
    KEGGibta:533896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118329 mRNA. Translation: AAI18330.1 .
    RefSeqi NP_001069472.1. NM_001076004.1.
    UniGenei Bt.23521.

    3D structure databases

    ProteinModelPortali Q17QJ3.
    SMRi Q17QJ3. Positions 61-210.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021830 ; ENSBTAP00000021830 ; ENSBTAG00000016413 .
    GeneIDi 533896.
    KEGGi bta:533896.

    Organism-specific databases

    CTDi 78986.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00550000074474.
    HOGENOMi HOG000233767.
    HOVERGENi HBG001524.
    InParanoidi Q17QJ3.
    KOi K14165.
    OMAi MAFMSRF.
    OrthoDBi EOG7CZK7N.
    TreeFami TF105128.

    Miscellaneous databases

    NextBioi 20876185.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiDUS26_BOVIN
    AccessioniPrimary (citable) accession number: Q17QJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3