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Q17QJ3

- DUS26_BOVIN

UniProt

Q17QJ3 - DUS26_BOVIN

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Protein

Dual specificity protein phosphatase 26

Gene
DUSP26
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP26
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 27

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292218Add
BLAST

Interactioni

Subunit structurei

Interacts with HSF4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ17QJ3.
SMRiQ17QJ3. Positions 61-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 206146Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00550000074474.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ17QJ3.
KOiK14165.
OMAiMAFMSRF.
OrthoDBiEOG7CZK7N.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MCPGNWLWAS VTFMARFSRS GSRSPVRVRG ALEEPPAVQH PFLNVFELER    50
LLYTGKTACN HADEVWPGLY LGDQEIANNH RELRRLGITH VLNASHSRWR 100
GTPEAYEGLG IRYLGVEAHD SPAFDMSVHF QAAADFIHRA LSQPGGRILV 150
HCAVGVSRSA TLVLAYLMLY HRLTLVEAIK KVKDHRGIIP NRGFLRQLLA 200
LDRRLRQGLE A 211
Length:211
Mass (Da):23,767
Last modified:July 25, 2006 - v1
Checksum:i4A576DD55BF6770E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118329 mRNA. Translation: AAI18330.1.
RefSeqiNP_001069472.1. NM_001076004.1.
UniGeneiBt.23521.

Genome annotation databases

EnsembliENSBTAT00000021830; ENSBTAP00000021830; ENSBTAG00000016413.
GeneIDi533896.
KEGGibta:533896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118329 mRNA. Translation: AAI18330.1 .
RefSeqi NP_001069472.1. NM_001076004.1.
UniGenei Bt.23521.

3D structure databases

ProteinModelPortali Q17QJ3.
SMRi Q17QJ3. Positions 61-210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021830 ; ENSBTAP00000021830 ; ENSBTAG00000016413 .
GeneIDi 533896.
KEGGi bta:533896.

Organism-specific databases

CTDi 78986.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00550000074474.
HOGENOMi HOG000233767.
HOVERGENi HBG001524.
InParanoidi Q17QJ3.
KOi K14165.
OMAi MAFMSRF.
OrthoDBi EOG7CZK7N.
TreeFami TF105128.

Miscellaneous databases

NextBioi 20876185.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiDUS26_BOVIN
AccessioniPrimary (citable) accession number: Q17QJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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