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Protein

Solute carrier family 25 member 39

Gene

SLC25A39

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHeme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:34764 SLC25A39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei256 – 276Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei318 – 338Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897211 – 359Solute carrier family 25 member 39Add BLAST359

Proteomic databases

PaxDbiQ17QI7
PRIDEiQ17QI7

Expressioni

Gene expression databases

BgeeiENSBTAG00000019463

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025926

Structurei

3D structure databases

ProteinModelPortaliQ17QI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 151Solcar 1Add BLAST143
Repeati159 – 243Solcar 2Add BLAST85
Repeati253 – 347Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761 Eukaryota
ENOG410XQVP LUCA
GeneTreeiENSGT00790000123051
HOGENOMiHOG000214473
HOVERGENiHBG011439
InParanoidiQ17QI7
KOiK15119
OMAiICWTVLE
OrthoDBiEOG091G07QQ
TreeFamiTF314720

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q17QI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSVASEL
60 70 80 90 100
MPPSRLWSLS YAKLPSSLRS TGKCLLYCNG VLEPLYLCPN GARCATWFQD
110 120 130 140 150
PTRFTGTMDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAA YFTAYDQLKA
160 170 180 190 200
FLCGRALTSD LYAPMVAGAL ARLGTVTVIS PLELVRTKLQ AQHLSYRELG
210 220 230 240 250
TCVRAAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLSGLRPK
260 270 280 290 300
DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQVALGAV EALRVMPLNT
310 320 330 340 350
DSTWLLLRRI LAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKNFFQR

LNREQLLSP
Note: No experimental confirmation available.
Length:359
Mass (Da):39,148
Last modified:May 29, 2007 - v2
Checksum:iBD024EB3EFA5354A
GO
Isoform 2 (identifier: Q17QI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-72: LPSSLRSTG → W

Show »
Length:351
Mass (Da):38,435
Checksum:i208FD1D32239F4AE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02602264 – 72LPSSLRSTG → W in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118337 mRNA Translation: AAI18338.1
RefSeqiNP_001068883.1, NM_001075415.1 [Q17QI7-2]
XP_005220900.1, XM_005220843.3 [Q17QI7-1]
UniGeneiBt.21718

Genome annotation databases

EnsembliENSBTAT00000025926; ENSBTAP00000025926; ENSBTAG00000019463 [Q17QI7-1]
GeneIDi509684
KEGGibta:509684

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2539_BOVIN
AccessioniPrimary (citable) accession number: Q17QI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health