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Q17QI2 (SSU72_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Gene names
Name:SSU72
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly in the cytosol By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdephosphorylation of RNA polymerase II C-terminal domain

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA polyadenylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionCTD phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000330011

Regions

Coiled coil160 – 18627 Potential

Sequences

Sequence LengthMass (Da)Tools
Q17QI2 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: CA252E57BD278A77

FASTA19422,588
        10         20         30         40         50         60 
MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT 

        70         80         90        100        110        120 
YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV 

       130        140        150        160        170        180 
EDLNSREQET CQPVHVINVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE 

       190 
EKSGRTFLHT VCFY 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118344 mRNA. Translation: AAI18345.1.
RefSeqNP_001069817.1. NM_001076349.1.
UniGeneBt.59246.

3D structure databases

ProteinModelPortalQ17QI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000003331.

Proteomic databases

PRIDEQ17QI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID614837.
KEGGbta:614837.

Organism-specific databases

CTD29101.

Phylogenomic databases

eggNOGCOG5211.
HOGENOMHOG000183445.
HOVERGENHBG059831.
InParanoidQ17QI2.
KOK15544.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20899312.

Entry information

Entry nameSSU72_BOVIN
AccessionPrimary (citable) accession number: Q17QI2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families