Q17QI2 (SSU72_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Short name=CTD phosphatase SSU72
EC=3.1.3.16

Gene names

Name:

SSU72

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly in the cytosol By similarity.
Sequence similarities	Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation of RNA polymerase II C-terminal domain Inferred from sequence or structural similarity. Source: UniProtKB mRNA polyadenylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	CTD phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	RNA polymerase II subunit A C-terminal domain phosphatase SSU72		PRO_0000330011
Regions
	Coiled coil	160 – 186	27	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q17QI2 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: CA252E57BD278A77	FASTA	194	22,588
	10 20 30 40 50 60 MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT 70 80 90 100 110 120 YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV 130 140 150 160 170 180 EDLNSREQET CQPVHVINVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE 190 EKSGRTFLHT VCFY

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118344 mRNA. Translation: AAI18345.1.
IPI	IPI00712432.
RefSeq	NP_001069817.1. NM_001076349.1.
UniGene	Bt.59246.
3D structure databases
ProteinModelPortal	Q17QI2.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000003331.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	614837.
KEGG	bta:614837.
Organism-specific databases
CTD	29101.
Phylogenomic databases
eggNOG	COG5211.
HOGENOM	HOG000183445.
HOVERGEN	HBG059831.
InParanoid	Q17QI2.
KO	K15544.
OrthoDB	EOG49PB0D.
Gene expression databases
ArrayExpress	Q17QI2.
Family and domain databases
InterPro	IPR006811. RNA_pol_II_suA. [Graphical view]
PANTHER	PTHR20383. PTHR20383. 1 hit.
Pfam	PF04722. Ssu72. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20899312.

Entry information

Entry name

SSU72_BOVIN

Accession

Primary (citable) accession number: Q17QI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 25, 2006
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program