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Q17QI2

- SSU72_BOVIN

UniProt

Q17QI2 - SSU72_BOVIN

Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. CTD phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
    2. mRNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase SSU72
    Gene namesi
    Name:SSU72
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Predominantly in the cytosol.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000330011Add
    BLAST

    Proteomic databases

    PRIDEiQ17QI2.

    Interactioni

    Subunit structurei

    Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000003331.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17QI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili160 – 18627Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    HOVERGENiHBG059831.
    InParanoidiQ17QI2.
    KOiK15544.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17QI2-1 [UniParc]FASTAAdd to Basket

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    MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD    50
    KPNVYDFKTT YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN 100
    CKDLFDLILT CEERVYDQVV EDLNSREQET CQPVHVINVD IQDNHEEATL 150
    GAFLICELCQ CIQHTEDMEN EIDELLQEFE EKSGRTFLHT VCFY 194
    Length:194
    Mass (Da):22,588
    Last modified:July 25, 2006 - v1
    Checksum:iCA252E57BD278A77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118344 mRNA. Translation: AAI18345.1.
    RefSeqiNP_001069817.1. NM_001076349.1.
    UniGeneiBt.59246.

    Genome annotation databases

    GeneIDi614837.
    KEGGibta:614837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118344 mRNA. Translation: AAI18345.1 .
    RefSeqi NP_001069817.1. NM_001076349.1.
    UniGenei Bt.59246.

    3D structure databases

    ProteinModelPortali Q17QI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000003331.

    Proteomic databases

    PRIDEi Q17QI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 614837.
    KEGGi bta:614837.

    Organism-specific databases

    CTDi 29101.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    HOVERGENi HBG059831.
    InParanoidi Q17QI2.
    KOi K15544.

    Miscellaneous databases

    NextBioi 20899312.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.

    Entry informationi

    Entry nameiSSU72_BOVIN
    AccessioniPrimary (citable) accession number: Q17QI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3