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Protein

Nuclear migration protein nudC

Gene

NUDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2500257. Resolution of Sister Chromatid Cohesion.
R-BTA-5663220. RHO GTPases Activate Formins.
R-BTA-68877. Mitotic Prometaphase.
R-BTA-68884. Mitotic Telophase/Cytokinesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear migration protein nudC
Alternative name(s):
Nuclear distribution protein C homolog
Gene namesi
Name:NUDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Nucleus By similarity

  • Note: A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277341 – 332Nuclear migration protein nudCAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphothreonineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei240N6-acetyllysineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei275Phosphoserine; by PLK1By similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei327Phosphoserine; by PLK1By similarity1

Post-translational modificationi

Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ17QG2.
PeptideAtlasiQ17QG2.
PRIDEiQ17QG2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004416.

Interactioni

Subunit structurei

Binds PLK1 and PAFAH1B1. Part of a complex containing PLK1, NUDC, dynein and dynactin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005789.

Structurei

3D structure databases

ProteinModelPortaliQ17QG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 259CSPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 134Sequence analysisAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 74Nuclear localization signalSequence analysis7

Sequence similaritiesi

Belongs to the nudC family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000182245.
HOVERGENiHBG052690.
InParanoidiQ17QG2.
OMAiINTRKIN.
OrthoDBiEOG091G0BZ5.
TreeFamiTF300147.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR032572. NuDC.
IPR025934. NudC_N_dom.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF16273. NuDC. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEQEEDRF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFVGGEEGM
60 70 80 90 100
AEKLITQTFN HHNQLAQKAR REKRARQETE RREKAERAAR LAKEAKSETS
110 120 130 140 150
GPQIKELTDE EAERLQLEID QKKDAENQEA QLKNGSLGSP GKQEAEEEEE
160 170 180 190 200
EDDEKDKGKL KPNLGNGADL PSYRWTQTLS ELDLAVPFCV NFRLKGKDVV
210 220 230 240 250
VDIQRRHLRV GLKGQPAIVD GELYNEVKVE ESSWLIEDGK VVTVHLEKIN
260 270 280 290 300
KMEWWSRLVS SDPEINTKKI NPENSKLSDL DSETRSMVEK MMYDQRQKSM
310 320 330
GLPTSDEQKK QEILKKFMDQ HPEMDFSKAR FN
Length:332
Mass (Da):38,243
Last modified:July 25, 2006 - v1
Checksum:i05F646A960A7AE6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118381 mRNA. Translation: AAI18382.1.
RefSeqiNP_001069075.1. NM_001075607.2.
UniGeneiBt.5486.

Genome annotation databases

EnsembliENSBTAT00000005789; ENSBTAP00000005789; ENSBTAG00000004416.
GeneIDi513277.
KEGGibta:513277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118381 mRNA. Translation: AAI18382.1.
RefSeqiNP_001069075.1. NM_001075607.2.
UniGeneiBt.5486.

3D structure databases

ProteinModelPortaliQ17QG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005789.

Proteomic databases

PaxDbiQ17QG2.
PeptideAtlasiQ17QG2.
PRIDEiQ17QG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005789; ENSBTAP00000005789; ENSBTAG00000004416.
GeneIDi513277.
KEGGibta:513277.

Organism-specific databases

CTDi10726.

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000182245.
HOVERGENiHBG052690.
InParanoidiQ17QG2.
OMAiINTRKIN.
OrthoDBiEOG091G0BZ5.
TreeFamiTF300147.

Enzyme and pathway databases

ReactomeiR-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2500257. Resolution of Sister Chromatid Cohesion.
R-BTA-5663220. RHO GTPases Activate Formins.
R-BTA-68877. Mitotic Prometaphase.
R-BTA-68884. Mitotic Telophase/Cytokinesis.

Gene expression databases

BgeeiENSBTAG00000004416.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR032572. NuDC.
IPR025934. NudC_N_dom.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF16273. NuDC. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC_BOVIN
AccessioniPrimary (citable) accession number: Q17QG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.