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Protein

Nuclear migration protein nudC

Gene

NUDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-BTA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-BTA-2467813 Separation of Sister Chromatids
R-BTA-2500257 Resolution of Sister Chromatid Cohesion
R-BTA-5663220 RHO GTPases Activate Formins
R-BTA-68877 Mitotic Prometaphase
R-BTA-68884 Mitotic Telophase/Cytokinesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear migration protein nudC
Alternative name(s):
Nuclear distribution protein C homolog
Gene namesi
Name:NUDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:32321 NUDC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277341 – 332Nuclear migration protein nudCAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphothreonineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei240N6-acetyllysineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei275Phosphoserine; by PLK1By similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei327Phosphoserine; by PLK1By similarity1

Post-translational modificationi

Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ17QG2
PeptideAtlasiQ17QG2
PRIDEiQ17QG2

Expressioni

Gene expression databases

BgeeiENSBTAG00000004416

Interactioni

Subunit structurei

Interacts with PLK1, PAFAH1B1 and DCDC5. Part of a complex containing PLK1, NUDC, dynein and dynactin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005789

Structurei

3D structure databases

ProteinModelPortaliQ17QG2
SMRiQ17QG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 259CSPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 134Sequence analysisAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 74Nuclear localization signalSequence analysis7

Sequence similaritiesi

Belongs to the nudC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00530000063486
HOGENOMiHOG000182245
HOVERGENiHBG052690
InParanoidiQ17QG2
OMAiNHHNQLA
OrthoDBiEOG091G0BZ5
TreeFamiTF300147

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR032572 NuDC
IPR037898 NudC_fam
IPR025934 NudC_N_dom
PANTHERiPTHR12356 PTHR12356, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF16273 NuDC, 1 hit
PF14050 Nudc_N, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit

Sequencei

Sequence statusi: Complete.

Q17QG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEQEEDRF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFVGGEEGM
60 70 80 90 100
AEKLITQTFN HHNQLAQKAR REKRARQETE RREKAERAAR LAKEAKSETS
110 120 130 140 150
GPQIKELTDE EAERLQLEID QKKDAENQEA QLKNGSLGSP GKQEAEEEEE
160 170 180 190 200
EDDEKDKGKL KPNLGNGADL PSYRWTQTLS ELDLAVPFCV NFRLKGKDVV
210 220 230 240 250
VDIQRRHLRV GLKGQPAIVD GELYNEVKVE ESSWLIEDGK VVTVHLEKIN
260 270 280 290 300
KMEWWSRLVS SDPEINTKKI NPENSKLSDL DSETRSMVEK MMYDQRQKSM
310 320 330
GLPTSDEQKK QEILKKFMDQ HPEMDFSKAR FN
Length:332
Mass (Da):38,243
Last modified:July 25, 2006 - v1
Checksum:i05F646A960A7AE6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118381 mRNA Translation: AAI18382.1
RefSeqiNP_001069075.1, NM_001075607.2
UniGeneiBt.5486

Genome annotation databases

EnsembliENSBTAT00000005789; ENSBTAP00000005789; ENSBTAG00000004416
GeneIDi513277
KEGGibta:513277

Similar proteinsi

Entry informationi

Entry nameiNUDC_BOVIN
AccessioniPrimary (citable) accession number: Q17QG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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