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Protein

EEF1A lysine methyltransferase 1

Gene

EEF1AKMT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6AMT2UniRule annotation
Gene namesi
Name:EEF1AKMT1UniRule annotation
Synonyms:N6AMT2UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:28333 EEF1AKMT1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003112932 – 226EEF1A lysine methyltransferase 1Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ17QF2
PRIDEiQ17QF2

Expressioni

Gene expression databases

BgeeiENSBTAG00000008296

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010916

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350 Eukaryota
ENOG4111GGY LUCA
GeneTreeiENSGT00390000016366
HOGENOMiHOG000240418
HOVERGENiHBG059901
InParanoidiQ17QF2
OMAiFAMYGEE
OrthoDBiEOG091G0GA7
TreeFamiTF106153

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSENEGPP QLSSYALAAL QEFYAEQQHH HSDLCGDDKY NIGIIEENWQ
60 70 80 90 100
LSQFWYSPET ATCLAEDAVA AAGEGGRIAC VSAPSVYQKL RERHRDDVSV
110 120 130 140 150
CIFEYDRRFA IYGEDFVYYD YKNPVDLPER IATHSFDIVV ADPPYLSEEC
160 170 180 190 200
LRKMSETIKL LTRGKILLCT GAVMEDAAAK LLGVKMCKFI PEHTRTLGNE
210 220
FRCFVNYNSG LDCNLSVQLP VQEGPK
Length:226
Mass (Da):25,495
Last modified:July 25, 2006 - v1
Checksum:iB567B71E8570B98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118400 mRNA Translation: AAI18401.1
RefSeqiNP_001073818.1, NM_001080349.2
XP_005213867.1, XM_005213810.3
XP_005213868.1, XM_005213811.3
XP_005213869.1, XM_005213812.3
UniGeneiBt.44991

Genome annotation databases

EnsembliENSBTAT00000010916; ENSBTAP00000010916; ENSBTAG00000008296
GeneIDi783374
KEGGibta:783374

Similar proteinsi

Entry informationi

Entry nameiEFMT1_BOVIN
AccessioniPrimary (citable) accession number: Q17QF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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