Reviewed, UniProtKB/Swiss-Prot Q17QF0 (AGT2_BOVIN)

Names and origin

Protein names

Recommended name:
    Alanine--glyoxylate aminotransferase 2, mitochondrial
      Short name=AGT 2
    EC=2.6.1.44
Alternative name(s):
    (R)-3-amino-2-methylpropionate--pyruvate transaminase
    EC=2.6.1.40
    Beta-alanine-pyruvate aminotransferase
    Beta-ALAAT II
    D-AIBAT

Gene names

Name:

AGXT2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-alanine + glyoxylate = pyruvate + glycine. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity Inferred from electronic annotation. Source: EC alanine-glyoxylate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 41	41	Mitochondrion By similarity
	Chain	42 – 514	473	Alanine--glyoxylate aminotransferase 2, mitochondrial		PRO_0000292950
Amino acid modifications
	Modified residue	350	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17QF0-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 0DBDF242C3D338C5	FASTA	514	57,226
	10 20 30 40 50 60 MTGAWGHLLR SLHLKTLSLW IPKTCFSLKA RAFWTSVTRC GLHTKPSMPP CDFTPERYQS 70 80 90 100 110 120 LAYSRVLEIH KQHLSPVHTA YFPEPLLLHQ GHVEWLFDHE GNRYLDFFSG IVTVSVGHCH 130 140 150 160 170 180 PKVNAAAQRQ LGRLWHTSSV FFHPLIHEYA EKLSALLPEP LKVVFLVNSG SEANDLAMLM 190 200 210 220 230 240 ARAHSNSTDI ISFRGAYHGC SPYTLGLTNV GIYKMDLPHG MGCQPTMCPD IFHGPWGGSH 250 260 270 280 290 300 CRDSPVQTIR KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK 310 320 330 340 350 360 GFLKEAFELV RERGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK GIGNGFPMAA 370 380 390 400 410 420 VVTTPDIAKS LTKRMLHFNT FGGNPMACAV GSAVLEVIKE ENLQENSQEV GTYMLLKLAK 430 440 450 460 470 480 LRDEFEIVGD VRGKGLMIGI EMVKDKESRQ PLPREEVNQI HHDCKCMGLL IGRGGLFSQT 490 500 510 FRIAPSMCIT KPEVDFAVEV FRSALIQHME RRAK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118402 mRNA. Translation: AAI18403.1.
IPI	IPI00711870.
RefSeq	NP_001069289.1.
UniGene	Bt.55194
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q17QF0.
Genome annotation databases
Ensembl	ENSBTAT00000010113; ENSBTAP00000010113; ENSBTAG00000007690; Bos taurus. [Genome view]
GeneID	521553.
KEGG	bta:521553.
Organism-specific databases
CTD	521553.
Phylogenomic databases
eggNOG	maNOG11671.
HOVERGEN	Q17QF0.
InParanoid	Q17QF0.
Enzyme and pathway databases
BRENDA	2.6.1.40. 251. 2.6.1.44. 251.
Family and domain databases
InterPro	IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGT2_BOVIN

Accession

Primary (citable) accession number: Q17QF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 25, 2006
Last modified:	January 19, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)