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Q17QF0 (AGT2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine--glyoxylate aminotransferase 2, mitochondrial
Short name=AGT 2
EC=2.6.1.44
Alternative name(s):
(R)-3-amino-2-methylpropionate--pyruvate transaminase
EC=2.6.1.40
Beta-ALAAT II
Beta-alanine-pyruvate aminotransferase
D-AIBAT
Gene names
Name:AGXT2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-alanine + glyoxylate = pyruvate + glycine.

(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4141Mitochondrion By similarity
Chain42 – 514473Alanine--glyoxylate aminotransferase 2, mitochondrial
PRO_0000292950

Amino acid modifications

Modified residue3501N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17QF0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 0DBDF242C3D338C5

FASTA51457,226
        10         20         30         40         50         60 
MTGAWGHLLR SLHLKTLSLW IPKTCFSLKA RAFWTSVTRC GLHTKPSMPP CDFTPERYQS 

        70         80         90        100        110        120 
LAYSRVLEIH KQHLSPVHTA YFPEPLLLHQ GHVEWLFDHE GNRYLDFFSG IVTVSVGHCH 

       130        140        150        160        170        180 
PKVNAAAQRQ LGRLWHTSSV FFHPLIHEYA EKLSALLPEP LKVVFLVNSG SEANDLAMLM 

       190        200        210        220        230        240 
ARAHSNSTDI ISFRGAYHGC SPYTLGLTNV GIYKMDLPHG MGCQPTMCPD IFHGPWGGSH 

       250        260        270        280        290        300 
CRDSPVQTIR KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK 

       310        320        330        340        350        360 
GFLKEAFELV RERGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK GIGNGFPMAA 

       370        380        390        400        410        420 
VVTTPDIAKS LTKRMLHFNT FGGNPMACAV GSAVLEVIKE ENLQENSQEV GTYMLLKLAK 

       430        440        450        460        470        480 
LRDEFEIVGD VRGKGLMIGI EMVKDKESRQ PLPREEVNQI HHDCKCMGLL IGRGGLFSQT 

       490        500        510 
FRIAPSMCIT KPEVDFAVEV FRSALIQHME RRAK

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC118402 mRNA. Translation: AAI18403.1.
IPIIPI00711870.
RefSeqNP_001069289.1. NM_001075821.1.
UniGeneBt.55194.

3D structure databases

ProteinModelPortalQ17QF0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ17QF0.

Proteomic databases

PRIDEQ17QF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID521553.
KEGGbta:521553.

Organism-specific databases

CTD64902.

Phylogenomic databases

eggNOGmaNOG11671.
GeneTreeENSGT00530000062907.
HOVERGENHBG004196.
InParanoidQ17QF0.
OrthoDBEOG4Q84X7.

Family and domain databases

InterProIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK00827.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGT2_BOVIN
AccessionPrimary (citable) accession number: Q17QF0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 25, 2006
Last modified: November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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