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Protein

LIM and cysteine-rich domains protein 1

Gene

LMCD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and cysteine-rich domains protein 1
Gene namesi
Name:LMCD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: May shuttle between the cytoplasm and the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363LIM and cysteine-rich domains protein 1PRO_0000252665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ17QE2.
PRIDEiQ17QE2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005431.

Interactioni

Subunit structurei

Interacts with beta-dystroglycan. Interacts with GATA1, GATA4 and GATA6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 206108PETPROSITE-ProRule annotationAdd
BLAST
Domaini239 – 30466LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini305 – 36359LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 5831Cys-richAdd
BLAST

Domaini

The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.By similarity

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation
Contains 1 PET domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGI. Eukaryota.
ENOG410ZPX3. LUCA.
GeneTreeiENSGT00550000074438.
HOGENOMiHOG000231628.
HOVERGENiHBG001038.
InParanoidiQ17QE2.
OMAiAGYSKQW.
OrthoDBiEOG091G07C5.
TreeFamiTF313265.

Family and domain databases

CDDicd09829. PET_testin. 1 hit.
Gene3Di2.10.110.10. 2 hits.
InterProiIPR010442. PET_domain.
IPR033724. PET_testin.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17QE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVAKDLNP RVQKMSLGQQ QSARGVPCLR CKGTCSGFEP HSWRKICKSC
60 70 80 90 100
KCSQEDHCLS SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI
110 120 130 140 150
MTNPIATGKD PTFDTITYEW APPGVTQKLG LQYMELIPKE KQPVTGTEGA
160 170 180 190 200
LYRRRQLMHQ LPIYDQDPSR CRGLLENELK VMEEFVKQYK SEALGVGEVA
210 220 230 240 250
LPGQGGLPKE EGKQQEKPEG AETAPPTTNG SIGDPSKEYV CELCKGVAPA
260 270 280 290 300
DSPVVYSDRA GYSKQWHPAC FVCAKCSEPL VDLIYFWKDG APWCGRHYCE
310 320 330 340 350
SLRPRCSGCD EIIFSEDYQR VEDLAWHRKH FVCEGCEQQL GGRAYIVTMG
360
QLLCPTCSKS KRS
Length:363
Mass (Da):40,723
Last modified:July 25, 2006 - v1
Checksum:i7115263766A64F39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118414 mRNA. Translation: AAI18415.1.
RefSeqiNP_001069690.1. NM_001076222.2.
UniGeneiBt.43510.

Genome annotation databases

EnsembliENSBTAT00000007149; ENSBTAP00000007149; ENSBTAG00000005431.
GeneIDi540474.
KEGGibta:540474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118414 mRNA. Translation: AAI18415.1.
RefSeqiNP_001069690.1. NM_001076222.2.
UniGeneiBt.43510.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007149.

Proteomic databases

PaxDbiQ17QE2.
PRIDEiQ17QE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007149; ENSBTAP00000007149; ENSBTAG00000005431.
GeneIDi540474.
KEGGibta:540474.

Organism-specific databases

CTDi29995.

Phylogenomic databases

eggNOGiENOG410INGI. Eukaryota.
ENOG410ZPX3. LUCA.
GeneTreeiENSGT00550000074438.
HOGENOMiHOG000231628.
HOVERGENiHBG001038.
InParanoidiQ17QE2.
OMAiAGYSKQW.
OrthoDBiEOG091G07C5.
TreeFamiTF313265.

Enzyme and pathway databases

ReactomeiR-BTA-5683826. Surfactant metabolism.

Gene expression databases

BgeeiENSBTAG00000005431.

Family and domain databases

CDDicd09829. PET_testin. 1 hit.
Gene3Di2.10.110.10. 2 hits.
InterProiIPR010442. PET_domain.
IPR033724. PET_testin.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMCD1_BOVIN
AccessioniPrimary (citable) accession number: Q17QE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.