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Q17QD8

- ETBR2_BOVIN

UniProt

Q17QD8 - ETBR2_BOVIN

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Protein
Prosaposin receptor GPR37L1
Gene
GPR37L1, ETBRLP2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 134109Extracellular Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini156 – 16712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini189 – 20517Extracellular Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini227 – 25125Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini273 – 31038Extracellular Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini332 – 36130Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini383 – 39816Extracellular Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini420 – 48263Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 482457Prosaposin receptor GPR37L1
PRO_0000307928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi203 ↔ 286 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019957.

Structurei

3D structure databases

ProteinModelPortaliQ17QD8.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00690000101856.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ17QD8.
KOiK04244.
OMAiVWHSYYL.
OrthoDBiEOG7CVPXV.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QD8-1 [UniParc]FASTAAdd to Basket

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MRWLWPLGVS LAVALAAGPE RAPRGVWLQQ GGHQPVAQEQ PDRSRRGAER    50
EDAKGLQQYV PEGWAEYPRP IRPAALQPTQ PWVAASPSPD RARATGGSGQ 100
EPQGNVTGPP GQRPQVQNPL YPVTERSYGA YAVLLLALLL FAVGIVGSLA 150
VMCIVWHSYY LKSAWNSVLA SLALWDFLVL FFCLPVVTFH EITKQRLLGA 200
VSCRAVPFVE VSSLGVTTFS LCALGIDRFH VATSTLPKAR PIEPCPSILA 250
KLAVIWVGSM TLAAPELLLW QLVREPSPAA GTVDTCIMKP SAHLPESLYS 300
LVLTYQNARM WWSFGCYFCL PVLFTVTCQL VTWRVRGTPG RKPESRPGPQ 350
EPRGARPSST VAGLAAVHAL CALPENVCNV VAAYLSAALT RQTLELLGLV 400
TQFSTFFKAA LTPLLLLCVS RPLGRAFLDC CCCCCGEGCG EGCGGRAAPA 450
GPRAKLHTEL SASGYFHKPR EAPPLLALGT PC 482
Length:482
Mass (Da):51,930
Last modified:July 25, 2006 - v1
Checksum:i9792F2310AB4A33C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118418 mRNA. Translation: AAI18419.1.
RefSeqiNP_001069367.1. NM_001075899.2.
UniGeneiBt.41530.

Genome annotation databases

EnsembliENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992.
GeneIDi527572.
KEGGibta:527572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118418 mRNA. Translation: AAI18419.1 .
RefSeqi NP_001069367.1. NM_001075899.2.
UniGenei Bt.41530.

3D structure databases

ProteinModelPortali Q17QD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000019957.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000019957 ; ENSBTAP00000019957 ; ENSBTAG00000014992 .
GeneIDi 527572.
KEGGi bta:527572.

Organism-specific databases

CTDi 9283.

Phylogenomic databases

eggNOGi NOG291459.
GeneTreei ENSGT00690000101856.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi Q17QD8.
KOi K04244.
OMAi VWHSYYL.
OrthoDBi EOG7CVPXV.
TreeFami TF331292.

Miscellaneous databases

NextBioi 20874622.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiETBR2_BOVIN
AccessioniPrimary (citable) accession number: Q17QD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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