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Q17QD8

- ETBR2_BOVIN

UniProt

Q17QD8 - ETBR2_BOVIN

Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37L1
    Alternative name(s):
    Endothelin B receptor-like protein 2
    Short name:
    ETBR-LP-2
    G-protein coupled receptor 37-like 1
    Gene namesi
    Name:GPR37L1
    Synonyms:ETBRLP2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 482457Prosaposin receptor GPR37L1PRO_0000307928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000019957.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17QD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 134109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 36130CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini383 – 39816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 48263CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi418 – 43922Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiQ17QD8.
    KOiK04244.
    OMAiVWHSYYL.
    OrthoDBiEOG7CVPXV.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q17QD8-1 [UniParc]FASTAAdd to Basket

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    MRWLWPLGVS LAVALAAGPE RAPRGVWLQQ GGHQPVAQEQ PDRSRRGAER    50
    EDAKGLQQYV PEGWAEYPRP IRPAALQPTQ PWVAASPSPD RARATGGSGQ 100
    EPQGNVTGPP GQRPQVQNPL YPVTERSYGA YAVLLLALLL FAVGIVGSLA 150
    VMCIVWHSYY LKSAWNSVLA SLALWDFLVL FFCLPVVTFH EITKQRLLGA 200
    VSCRAVPFVE VSSLGVTTFS LCALGIDRFH VATSTLPKAR PIEPCPSILA 250
    KLAVIWVGSM TLAAPELLLW QLVREPSPAA GTVDTCIMKP SAHLPESLYS 300
    LVLTYQNARM WWSFGCYFCL PVLFTVTCQL VTWRVRGTPG RKPESRPGPQ 350
    EPRGARPSST VAGLAAVHAL CALPENVCNV VAAYLSAALT RQTLELLGLV 400
    TQFSTFFKAA LTPLLLLCVS RPLGRAFLDC CCCCCGEGCG EGCGGRAAPA 450
    GPRAKLHTEL SASGYFHKPR EAPPLLALGT PC 482
    Length:482
    Mass (Da):51,930
    Last modified:July 25, 2006 - v1
    Checksum:i9792F2310AB4A33C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118418 mRNA. Translation: AAI18419.1.
    RefSeqiNP_001069367.1. NM_001075899.2.
    UniGeneiBt.41530.

    Genome annotation databases

    EnsembliENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992.
    GeneIDi527572.
    KEGGibta:527572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118418 mRNA. Translation: AAI18419.1 .
    RefSeqi NP_001069367.1. NM_001075899.2.
    UniGenei Bt.41530.

    3D structure databases

    ProteinModelPortali Q17QD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000019957.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000019957 ; ENSBTAP00000019957 ; ENSBTAG00000014992 .
    GeneIDi 527572.
    KEGGi bta:527572.

    Organism-specific databases

    CTDi 9283.

    Phylogenomic databases

    eggNOGi NOG291459.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi Q17QD8.
    KOi K04244.
    OMAi VWHSYYL.
    OrthoDBi EOG7CVPXV.
    TreeFami TF331292.

    Miscellaneous databases

    NextBioi 20874622.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.

    Entry informationi

    Entry nameiETBR2_BOVIN
    AccessioniPrimary (citable) accession number: Q17QD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3