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Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_297846. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 134109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini332 – 36130CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini383 – 39816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini420 – 48263CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 482457Prosaposin receptor GPR37L1PRO_0000307928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019957.

Structurei

3D structure databases

ProteinModelPortaliQ17QD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ17QD8.
KOiK04244.
OMAiSCRAVPF.
OrthoDBiEOG7CVPXV.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLWPLGVS LAVALAAGPE RAPRGVWLQQ GGHQPVAQEQ PDRSRRGAER
60 70 80 90 100
EDAKGLQQYV PEGWAEYPRP IRPAALQPTQ PWVAASPSPD RARATGGSGQ
110 120 130 140 150
EPQGNVTGPP GQRPQVQNPL YPVTERSYGA YAVLLLALLL FAVGIVGSLA
160 170 180 190 200
VMCIVWHSYY LKSAWNSVLA SLALWDFLVL FFCLPVVTFH EITKQRLLGA
210 220 230 240 250
VSCRAVPFVE VSSLGVTTFS LCALGIDRFH VATSTLPKAR PIEPCPSILA
260 270 280 290 300
KLAVIWVGSM TLAAPELLLW QLVREPSPAA GTVDTCIMKP SAHLPESLYS
310 320 330 340 350
LVLTYQNARM WWSFGCYFCL PVLFTVTCQL VTWRVRGTPG RKPESRPGPQ
360 370 380 390 400
EPRGARPSST VAGLAAVHAL CALPENVCNV VAAYLSAALT RQTLELLGLV
410 420 430 440 450
TQFSTFFKAA LTPLLLLCVS RPLGRAFLDC CCCCCGEGCG EGCGGRAAPA
460 470 480
GPRAKLHTEL SASGYFHKPR EAPPLLALGT PC
Length:482
Mass (Da):51,930
Last modified:July 25, 2006 - v1
Checksum:i9792F2310AB4A33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118418 mRNA. Translation: AAI18419.1.
RefSeqiNP_001069367.1. NM_001075899.2.
UniGeneiBt.41530.

Genome annotation databases

EnsembliENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992.
GeneIDi527572.
KEGGibta:527572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118418 mRNA. Translation: AAI18419.1.
RefSeqiNP_001069367.1. NM_001075899.2.
UniGeneiBt.41530.

3D structure databases

ProteinModelPortaliQ17QD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019957.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992.
GeneIDi527572.
KEGGibta:527572.

Organism-specific databases

CTDi9283.

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ17QD8.
KOiK04244.
OMAiSCRAVPF.
OrthoDBiEOG7CVPXV.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_297846. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi20874622.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiETBR2_BOVIN
AccessioniPrimary (citable) accession number: Q17QD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 25, 2006
Last modified: April 1, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.