Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q17QD8 (ETBR2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene names
Name:GPR37L1
Synonyms:ETBRLP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 482457Prosaposin receptor GPR37L1
PRO_0000307928

Regions

Topological domain26 – 134109Extracellular Potential
Transmembrane135 – 15521Helical; Name=1; Potential
Topological domain156 – 16712Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=2; Potential
Topological domain189 – 20517Extracellular Potential
Transmembrane206 – 22621Helical; Name=3; Potential
Topological domain227 – 25125Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=4; Potential
Topological domain273 – 31038Extracellular Potential
Transmembrane311 – 33121Helical; Name=5; Potential
Topological domain332 – 36130Cytoplasmic Potential
Transmembrane362 – 38221Helical; Name=6; Potential
Topological domain383 – 39816Extracellular Potential
Transmembrane399 – 41921Helical; Name=7; Potential
Topological domain420 – 48263Cytoplasmic Potential
Compositional bias418 – 43922Cys-rich

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond203 ↔ 286 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17QD8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 9792F2310AB4A33C

FASTA48251,930
        10         20         30         40         50         60 
MRWLWPLGVS LAVALAAGPE RAPRGVWLQQ GGHQPVAQEQ PDRSRRGAER EDAKGLQQYV 

        70         80         90        100        110        120 
PEGWAEYPRP IRPAALQPTQ PWVAASPSPD RARATGGSGQ EPQGNVTGPP GQRPQVQNPL 

       130        140        150        160        170        180 
YPVTERSYGA YAVLLLALLL FAVGIVGSLA VMCIVWHSYY LKSAWNSVLA SLALWDFLVL 

       190        200        210        220        230        240 
FFCLPVVTFH EITKQRLLGA VSCRAVPFVE VSSLGVTTFS LCALGIDRFH VATSTLPKAR 

       250        260        270        280        290        300 
PIEPCPSILA KLAVIWVGSM TLAAPELLLW QLVREPSPAA GTVDTCIMKP SAHLPESLYS 

       310        320        330        340        350        360 
LVLTYQNARM WWSFGCYFCL PVLFTVTCQL VTWRVRGTPG RKPESRPGPQ EPRGARPSST 

       370        380        390        400        410        420 
VAGLAAVHAL CALPENVCNV VAAYLSAALT RQTLELLGLV TQFSTFFKAA LTPLLLLCVS 

       430        440        450        460        470        480 
RPLGRAFLDC CCCCCGEGCG EGCGGRAAPA GPRAKLHTEL SASGYFHKPR EAPPLLALGT 


PC 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118418 mRNA. Translation: AAI18419.1.
RefSeqNP_001069367.1. NM_001075899.2.
UniGeneBt.41530.

3D structure databases

ProteinModelPortalQ17QD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000019957.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992.
GeneID527572.
KEGGbta:527572.

Organism-specific databases

CTD9283.

Phylogenomic databases

eggNOGNOG291459.
GeneTreeENSGT00690000101856.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidQ17QD8.
KOK04244.
OMAVWHSYYL.
OrthoDBEOG7CVPXV.
TreeFamTF331292.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874622.

Entry information

Entry nameETBR2_BOVIN
AccessionPrimary (citable) accession number: Q17QD8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries