Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:29586 GPR37L1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 134ExtracellularSequence analysisAdd BLAST109
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 361CytoplasmicSequence analysisAdd BLAST30
Transmembranei362 – 382Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini383 – 398ExtracellularSequence analysisAdd BLAST16
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 482CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000030792826 – 482Prosaposin receptor GPR37L1Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
Modified residuei480PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ17QD8

Expressioni

Gene expression databases

BgeeiENSBTAG00000014992

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019957

Structurei

3D structure databases

ProteinModelPortaliQ17QD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 439Cys-richAdd BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiQ17QD8
KOiK04244
OMAiTEMSSSI
OrthoDBiEOG091G053G
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLWPLGVS LAVALAAGPE RAPRGVWLQQ GGHQPVAQEQ PDRSRRGAER
60 70 80 90 100
EDAKGLQQYV PEGWAEYPRP IRPAALQPTQ PWVAASPSPD RARATGGSGQ
110 120 130 140 150
EPQGNVTGPP GQRPQVQNPL YPVTERSYGA YAVLLLALLL FAVGIVGSLA
160 170 180 190 200
VMCIVWHSYY LKSAWNSVLA SLALWDFLVL FFCLPVVTFH EITKQRLLGA
210 220 230 240 250
VSCRAVPFVE VSSLGVTTFS LCALGIDRFH VATSTLPKAR PIEPCPSILA
260 270 280 290 300
KLAVIWVGSM TLAAPELLLW QLVREPSPAA GTVDTCIMKP SAHLPESLYS
310 320 330 340 350
LVLTYQNARM WWSFGCYFCL PVLFTVTCQL VTWRVRGTPG RKPESRPGPQ
360 370 380 390 400
EPRGARPSST VAGLAAVHAL CALPENVCNV VAAYLSAALT RQTLELLGLV
410 420 430 440 450
TQFSTFFKAA LTPLLLLCVS RPLGRAFLDC CCCCCGEGCG EGCGGRAAPA
460 470 480
GPRAKLHTEL SASGYFHKPR EAPPLLALGT PC
Length:482
Mass (Da):51,930
Last modified:July 25, 2006 - v1
Checksum:i9792F2310AB4A33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118418 mRNA Translation: AAI18419.1
RefSeqiNP_001069367.1, NM_001075899.2
UniGeneiBt.41530

Genome annotation databases

EnsembliENSBTAT00000019957; ENSBTAP00000019957; ENSBTAG00000014992
GeneIDi527572
KEGGibta:527572

Entry informationi

Entry nameiETBR2_BOVIN
AccessioniPrimary (citable) accession number: Q17QD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health