Reviewed, UniProtKB/Swiss-Prot Q17QB3 (ASAH1_BOVIN)

Names and origin

Protein names

Recommended name:
    Acid ceramidase
      Short name=AC
    EC=3.5.1.23
Alternative name(s):
    Acylsphingosine deacylase
    N-acylsphingosine amidohydrolase

Gene names

Name:

ASAH1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.
Catalytic activity	N-acylsphingosine + H2O = a carboxylate + sphingosine.
Subunit structure	Heterodimer of one alpha and one beta subunit By similarity.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the acid ceramidase family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ceramidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 395	375	Acid ceramidase		PRO_0000378100
Amino acid modifications
	Glycosylation	195	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q17QB3-1 [UniParc]. Last modified January 15, 2008. Version 3. Checksum: DCDE643268CCB30A	FASTA	395	44,965
	10 20 30 40 50 60 MLGWSRLTFI LLSGIVTCLV AQQVPPWTED CRKSTYPPSG PTYRGPVPWY TINLDLPPYK 70 80 90 100 110 120 RWHELMVVKA PALKVIVNSM KNIVNAFVPS GKIIHLVDQK LPGLLGNFPG PFEEEMKGIA 130 140 150 160 170 180 AVTEIPLGEI ILFNIFYEFF TICTSIITED KEGHLLHGRN LDFGVFLGWN INNDTWVITE 190 200 210 220 230 240 ELKPLTVNLD FQRNNKTLFK ATTFAGYVGM LTGFKPGLFS VTLNERFSID GGFMGVMEWI 250 260 270 280 290 300 LGKKDAQWVG FIIRSVLENS TSYEETKNIL TKTKILAPAY FILGGNQSGE GCVITRDRKQ 310 320 330 340 350 360 SLDIYELDPK HGRWYVVQTN YDRWKNPFFL DDRRTPAKMC LNQTTQENIS FATIYDVLST 370 380 390 KPILNKLTVY TVLIDVTKGQ FETYLRDCPD PCIGW

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC118455 mRNA. Translation: AAI18456.3.
IPI	IPI00685320.
RefSeq	NP_001068927.1.
UniGene	Bt.62845
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q17QB3.
Genome annotation databases
Ensembl	ENSBTAT00000014960; ENSBTAP00000014960; ENSBTAG00000011257; Bos taurus. [Genome view]
GeneID	510620.
KEGG	bta:510620.
Organism-specific databases
CTD	510620.
Phylogenomic databases
HOVERGEN	Q17QB3.
Family and domain databases
InterPro	IPR016699. Acid_ceramidase-like. IPR003199. Chologlycine_hydro. [Graphical view]
Pfam	PF02275. CBAH. 1 hit. [Graphical view]
PIRSF	PIRSF017632. Acid_ceramidase-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASAH1_BOVIN

Accession

Primary (citable) accession number: Q17QB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	January 15, 2008
Last modified:	September 22, 2009
This is version 24 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)