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Q17QA1

- CCL4_BOVIN

UniProt

Q17QA1 - CCL4_BOVIN

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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_212617. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:SCY4A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009446.

Structurei

3D structure databases

ProteinModelPortaliQ17QA1.
SMRiQ17QA1. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ17QA1.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLMAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVND
60 70 80 90
YFETSSLCSQ PAVVFQTKKG RQVCANPSEP WVQEYVDDLE LN
Length:92
Mass (Da):10,184
Last modified:July 25, 2006 - v1
Checksum:i6E3162D9094F2774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118471 mRNA. Translation: AAI18472.1.
RefSeqiNP_001068615.1. NM_001075147.2.
UniGeneiBt.33440.

Genome annotation databases

EnsembliENSBTAT00000009446; ENSBTAP00000009446; ENSBTAG00000025257.
GeneIDi414347.
KEGGibta:414347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118471 mRNA. Translation: AAI18472.1 .
RefSeqi NP_001068615.1. NM_001075147.2.
UniGenei Bt.33440.

3D structure databases

ProteinModelPortali Q17QA1.
SMRi Q17QA1. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009446 ; ENSBTAP00000009446 ; ENSBTAG00000025257 .
GeneIDi 414347.
KEGGi bta:414347.

Organism-specific databases

CTDi 6351.

Phylogenomic databases

eggNOGi NOG124416.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q17QA1.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_212617. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20818702.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal brain.

Entry informationi

Entry nameiCCL4_BOVIN
AccessioniPrimary (citable) accession number: Q17QA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3