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Q17QA1

- CCL4_BOVIN

UniProt

Q17QA1 - CCL4_BOVIN

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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:SCY4A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009446.

Structurei

3D structure databases

ProteinModelPortaliQ17QA1.
SMRiQ17QA1. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ17QA1.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17QA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLMAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVND
60 70 80 90
YFETSSLCSQ PAVVFQTKKG RQVCANPSEP WVQEYVDDLE LN
Length:92
Mass (Da):10,184
Last modified:July 25, 2006 - v1
Checksum:i6E3162D9094F2774
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118471 mRNA. Translation: AAI18472.1.
RefSeqiNP_001068615.1. NM_001075147.2.
UniGeneiBt.33440.

Genome annotation databases

EnsembliENSBTAT00000009446; ENSBTAP00000009446; ENSBTAG00000025257.
GeneIDi414347.
KEGGibta:414347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118471 mRNA. Translation: AAI18472.1 .
RefSeqi NP_001068615.1. NM_001075147.2.
UniGenei Bt.33440.

3D structure databases

ProteinModelPortali Q17QA1.
SMRi Q17QA1. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009446 ; ENSBTAP00000009446 ; ENSBTAG00000025257 .
GeneIDi 414347.
KEGGi bta:414347.

Organism-specific databases

CTDi 6351.

Phylogenomic databases

eggNOGi NOG124416.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q17QA1.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20818702.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal brain.

Entry informationi

Entry nameiCCL4_BOVIN
AccessioniPrimary (citable) accession number: Q17QA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 25, 2006
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3