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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97NucleophileBy similarity1
Active sitei176Proton donorBy similarity1
Sitei191Important for enzyme activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:AAEL000787
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003958241 – 478Ubiquitin carboxyl-terminal hydrolase calypsoAdd BLAST478

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi7159.AAEL000787-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17N72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2778. Eukaryota.
ENOG410XP0P. LUCA.
HOGENOMiHOG000203918.
InParanoidiQ17N72.
KOiK08588.
OMAiHAMPQAR.
OrthoDBiEOG091G08R7.
PhylomeDBiQ17N72.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiView protein in InterPro
IPR001578. Peptidase_C12_UCH.
IPR036959. Peptidase_C12_UCH_sf.
PANTHERiPTHR10589. PTHR10589. 2 hits.
PfamiView protein in Pfam
PF01088. Peptidase_C12. 1 hit.
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q17N72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKNIEGPV
60 70 80 90 100
YGFIFLFRWI EERRARRKIV ETTEIYVKDE EAVNNIFFAQ QVVPNSCATH
110 120 130 140 150
ALLSVLLNCS DIDLGNTLSR LKVHTKGMCP ENKGWAIGNT PELACAHNSH
160 170 180 190 200
AMPQARRRMD RNSGVSTGRF TGEAFHFVSF VPINGHLFEL DGLKPFPMDH
210 220 230 240 250
GPWGEKEAWT DKFRRVMSDR LGISTGEQDI RFNLMAVVPD RRIAITHKLK
260 270 280 290 300
MLRTNQTIVS AALEKLLKSK RTESRSLETV DKIKKEEESP VKLSSEYSQL
310 320 330 340 350
LEMNEKDDSS VPMSKELESL VSLNSSSDSV EIIGETEIKK ENPPPSPPPS
360 370 380 390 400
FIGAGTFSPK DLLSLLKNLE SEINITEQHL CDENEKRAMF KVDDCRRTHN
410 420 430 440 450
YDEFICTFLS MLAHQGELGD LVSQHLITNR KPNMGSVQNS GSRGVVRNYN
460 470
KKTTTNGSSP KTPSSKRRRG RTKYRKRK
Length:478
Mass (Da):54,158
Last modified:July 25, 2006 - v1
Checksum:i80C8628EC07A5556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477201 Genomic DNA. Translation: EAT48182.1.
RefSeqiXP_001651006.1. XM_001650956.1.

Genome annotation databases

EnsemblMetazoaiAAEL000787-RA; AAEL000787-PA; AAEL000787.
GeneIDi5566609.
KEGGiaag:AaeL_AAEL000787.
VectorBaseiAAEL000787-RA; AAEL000787-PA; AAEL000787.

Similar proteinsi

Entry informationi

Entry nameiCALYP_AEDAE
AccessioniPrimary (citable) accession number: Q17N72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 25, 2006
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families