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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971NucleophileBy similarity
Active sitei176 – 1761Proton donorBy similarity
Sitei191 – 1911Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:AAEL000787
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395824Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi7159.AAEL000787-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17N72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000203918.
InParanoidiQ17N72.
KOiK08588.
OMAiAFHFVSF.
OrthoDBiEOG7GN2M2.
PhylomeDBiQ17N72.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q17N72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKNIEGPV
60 70 80 90 100
YGFIFLFRWI EERRARRKIV ETTEIYVKDE EAVNNIFFAQ QVVPNSCATH
110 120 130 140 150
ALLSVLLNCS DIDLGNTLSR LKVHTKGMCP ENKGWAIGNT PELACAHNSH
160 170 180 190 200
AMPQARRRMD RNSGVSTGRF TGEAFHFVSF VPINGHLFEL DGLKPFPMDH
210 220 230 240 250
GPWGEKEAWT DKFRRVMSDR LGISTGEQDI RFNLMAVVPD RRIAITHKLK
260 270 280 290 300
MLRTNQTIVS AALEKLLKSK RTESRSLETV DKIKKEEESP VKLSSEYSQL
310 320 330 340 350
LEMNEKDDSS VPMSKELESL VSLNSSSDSV EIIGETEIKK ENPPPSPPPS
360 370 380 390 400
FIGAGTFSPK DLLSLLKNLE SEINITEQHL CDENEKRAMF KVDDCRRTHN
410 420 430 440 450
YDEFICTFLS MLAHQGELGD LVSQHLITNR KPNMGSVQNS GSRGVVRNYN
460 470
KKTTTNGSSP KTPSSKRRRG RTKYRKRK
Length:478
Mass (Da):54,158
Last modified:July 25, 2006 - v1
Checksum:i80C8628EC07A5556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477201 Genomic DNA. Translation: EAT48182.1.
RefSeqiXP_001651006.1. XM_001650956.1.
UniGeneiAae.7505.

Genome annotation databases

EnsemblMetazoaiAAEL000787-RA; AAEL000787-PA; AAEL000787.
GeneIDi5566609.
KEGGiaag:AaeL_AAEL000787.
VectorBaseiAAEL000787. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477201 Genomic DNA. Translation: EAT48182.1.
RefSeqiXP_001651006.1. XM_001650956.1.
UniGeneiAae.7505.

3D structure databases

ProteinModelPortaliQ17N72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL000787-PA.

Protein family/group databases

MEROPSiC12.A09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL000787-RA; AAEL000787-PA; AAEL000787.
GeneIDi5566609.
KEGGiaag:AaeL_AAEL000787.
VectorBaseiAAEL000787. Aedes aegypti.

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000203918.
InParanoidiQ17N72.
KOiK08588.
OMAiAFHFVSF.
OrthoDBiEOG7GN2M2.
PhylomeDBiQ17N72.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiCALYP_AEDAE
AccessioniPrimary (citable) accession number: Q17N72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 25, 2006
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.