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Q17N72 (CALYP_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase calypso

EC=3.4.19.12
Alternative name(s):
BAP1 homolog
Gene names
Name:calypso
ORF Names:AAEL000787
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to PcG response elements (PREs) By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395824

Sites

Active site971Nucleophile By similarity
Active site1761Proton donor By similarity
Site1911Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17N72 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 80C8628EC07A5556

FASTA47854,158
        10         20         30         40         50         60 
MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKNIEGPV YGFIFLFRWI 

        70         80         90        100        110        120 
EERRARRKIV ETTEIYVKDE EAVNNIFFAQ QVVPNSCATH ALLSVLLNCS DIDLGNTLSR 

       130        140        150        160        170        180 
LKVHTKGMCP ENKGWAIGNT PELACAHNSH AMPQARRRMD RNSGVSTGRF TGEAFHFVSF 

       190        200        210        220        230        240 
VPINGHLFEL DGLKPFPMDH GPWGEKEAWT DKFRRVMSDR LGISTGEQDI RFNLMAVVPD 

       250        260        270        280        290        300 
RRIAITHKLK MLRTNQTIVS AALEKLLKSK RTESRSLETV DKIKKEEESP VKLSSEYSQL 

       310        320        330        340        350        360 
LEMNEKDDSS VPMSKELESL VSLNSSSDSV EIIGETEIKK ENPPPSPPPS FIGAGTFSPK 

       370        380        390        400        410        420 
DLLSLLKNLE SEINITEQHL CDENEKRAMF KVDDCRRTHN YDEFICTFLS MLAHQGELGD 

       430        440        450        460        470 
LVSQHLITNR KPNMGSVQNS GSRGVVRNYN KKTTTNGSSP KTPSSKRRRG RTKYRKRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH477201 Genomic DNA. Translation: EAT48182.1.
RefSeqXP_001651006.1. XM_001650956.1.
UniGeneAae.7505.

3D structure databases

ProteinModelPortalQ17N72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7159.AAEL000787-PA.

Protein family/group databases

MEROPSC12.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL000787-RA; AAEL000787-PA; AAEL000787.
GeneID5566609.
KEGGaag:AaeL_AAEL000787.
VectorBaseAAEL000787. Aedes aegypti.

Phylogenomic databases

eggNOGNOG249036.
HOGENOMHOG000203918.
KOK08588.
OMATDKFRRV.
OrthoDBEOG7GN2M2.
PhylomeDBQ17N72.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameCALYP_AEDAE
AccessionPrimary (citable) accession number: Q17N72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 25, 2006
Last modified: March 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries