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Q17M80 (MMSA_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Short name=MMSDH
Short name=Malonate-semialdehyde dehydrogenase [acylating]
EC=1.2.1.18
EC=1.2.1.27
Gene names
ORF Names:AAEL001134
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA By similarity. UniProtKB Q02252

Catalytic activity

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. UniProtKB Q02252

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. UniProtKB Q02252

Subunit structure

Homotetramer By similarity. UniProtKB Q02252

Subcellular location

Mitochondrion By similarity UniProtKB Q02252.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 521Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000312823

Regions

Nucleotide binding196 – 2005NAD Potential
Nucleotide binding248 – 2536NAD Potential

Sites

Active site3041Nucleophile By similarity UniProtKB Q02252
Binding site4041NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q17M80 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 9FC4A9E85D5F39A7

FASTA52156,572
        10         20         30         40         50         60 
MALVRLLGVE CRNALQRSYS TASVPTTKMF IDGKFVDSKT TEWIDLHDPA TNKVVTRVPK 

        70         80         90        100        110        120 
CTQDEMESAV ESSKKAFKTW SQTSILGRQQ VMFKLQHLIR NNMSELAKNI TKEQGKTLVD 

       130        140        150        160        170        180 
AEGDVLRGLQ VVEHCCSITS LQMGETVPNI AKDMDTYSYT LPLGVTAGIC PFNFPAMIPL 

       190        200        210        220        230        240 
WMFPVAITCG NTSIIKPSER VPGATMMLME LLNEAGCPPG VVNVIHGAHD AVNFICDNPT 

       250        260        270        280        290        300 
IKAVSFVGSD QAGKYIYERA GRNGKRVQSN MGAKNHGVIM ADANKENTLN QLAGAAFGAA 

       310        320        330        340        350        360 
GQRCMALSTA VFVGEAKQWI PDLVERARKL KVNAGHVPGT DVGPVISPQS KQRINELVES 

       370        380        390        400        410        420 
GVKEGAKLVL DGRSIKVENF ENGNFVGPTI LTDVSTNMKC YTEEIFGPVL VCLTVDTVDE 

       430        440        450        460        470        480 
AVEMINNNPY GNGTAIFTTN GATARKFVNE IDVGQVGVNV PIPVPLPMFS FTGSRGSFMG 

       490        500        510        520 
DCHFYGKQGV KFYTQTKTVT QLWREGDVSH TKAAVAMPTM K

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH477208 Genomic DNA. Translation: EAT47764.1.
RefSeqXP_001652386.1. XM_001652336.1.
UniGeneAae.2920.

3D structure databases

ProteinModelPortalQ17M80.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ17M80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL001134-RA; AAEL001134-PA; AAEL001134.
GeneID5568558.
KEGGaag:AaeL_AAEL001134.
VectorBaseAAEL001134. Aedes aegypti.

Phylogenomic databases

eggNOGinNOG06001.
GeneTreeEMGT00050000005689.
OMAKHIYERG.
OrthoDBEOG4N5TC3.
PhylomeDBQ17M80.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00140.
PANTHERPTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMMSA_AEDAE
AccessionPrimary (citable) accession number: Q17M80
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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