ID   ARM_AEDAE               Reviewed;         832 AA.
AC   Q17GS9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Armadillo segment polarity protein;
GN   Name=arm {ECO:0000250|UniProtKB:P18824}; ORFNames=AAEL002887;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT45858.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: May associate with CadN and participate in the transmission
CC       of developmental information. Can associate with alpha-catenin.
CC       Accumulates through wg signaling; arm function in wg signal
CC       transduction is required early in development for determination of
CC       neuroblast fate. Arm and Abl proteins function cooperatively at
CC       adherens junctions in both the CNS and epidermis (By similarity).
CC       {ECO:0000250|UniProtKB:P18824}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P18824}. Cell
CC       membrane {ECO:0000250|UniProtKB:P18824}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P18824}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P18824}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:P18824}. Note=Inner surface of cell membrane and
CC       adherens junction. {ECO:0000250|UniProtKB:P18824}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000255}.
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DR   EMBL; CH477256; EAT45858.1; -; Genomic_DNA.
DR   RefSeq; XP_001662670.1; XM_001662620.1.
DR   AlphaFoldDB; Q17GS9; -.
DR   SMR; Q17GS9; -.
DR   STRING; 7159.Q17GS9; -.
DR   PaxDb; 7159-AAEL002887-PA; -.
DR   EnsemblMetazoa; AAEL002887-RA; AAEL002887-PA; AAEL002887.
DR   EnsemblMetazoa; AAEL002887-RB; AAEL002887-PB; AAEL002887.
DR   EnsemblMetazoa; AAEL002887-RC; AAEL002887-PC; AAEL002887.
DR   GeneID; 5576477; -.
DR   KEGG; aag:5576477; -.
DR   VEuPathDB; VectorBase:AAEL002887; -.
DR   eggNOG; KOG4203; Eukaryota.
DR   HOGENOM; CLU_008757_1_1_1; -.
DR   InParanoid; Q17GS9; -.
DR   OMA; DPLMFDM; -.
DR   OrthoDB; 50711at2759; -.
DR   PhylomeDB; Q17GS9; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   Proteomes; UP000682892; Unassembled WGS sequence.
DR   GO; GO:0005912; C:adherens junction; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045296; F:cadherin binding; ISS:UniProtKB.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0014017; P:neuroblast fate commitment; ISS:UniProtKB.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   CDD; cd21726; CTNNAbd_dArm; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   PANTHER; PTHR45976; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR   PANTHER; PTHR45976:SF1; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR   Pfam; PF00514; Arm; 4.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 11.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   3: Inferred from homology;
KW   Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW   Developmental protein; Membrane; Reference proteome; Repeat;
KW   Segmentation polarity protein; Wnt signaling pathway.
FT   CHAIN           1..832
FT                   /note="Armadillo segment polarity protein"
FT                   /id="PRO_0000312833"
FT   REPEAT          146..185
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          188..228
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          230..269
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          272..311
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          356..395
FT                   /note="ARM 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          397..434
FT                   /note="ARM 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          483..524
FT                   /note="ARM 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          594..634
FT                   /note="ARM 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          636..675
FT                   /note="ARM 9"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..783
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..832
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  90307 MW;  6331B575249EE484 CRC64;
     MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT QVPSLSGKDD
     DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR AAMFPETLEE GIEIPSTQFD
     PQQPTAVQRL SEPSQMLKHA VVNLINYQDD ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV
     HQLSKKEASR HAIMNSPQMV AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG
     GIPALVKLLS SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
     IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK VLSVCSSNKP
     AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV DGLETLLSGL VTVLGSSDVN
     VVTCAAGILS NLTCNNQRNK VTVCQVGGVE ALVGTIINAG DREEITEPAV CALRHLTSRH
     PESESAQNIV RNGYGLPVIV KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL
     LVRLLFKAFQ DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI
     RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP LTELLNSANE
     GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM WNNGELGIGP DLQDILSPDQ
     AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA
     GGPPSGQPTS PYAMDMDVGE MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL
//