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Q17GS9

- ARM_AEDAE

UniProt

Q17GS9 - ARM_AEDAE

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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. intracellular protein transport Source: InterPro
  3. neuroblast fate commitment Source: UniProtKB
  4. segment polarity determination Source: UniProtKB-KW
  5. vesicle-mediated transport Source: InterPro
  6. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:armBy similarity
ORF Names:AAEL002887
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction.By similarity

GO - Cellular componenti

  1. adherens junction Source: UniProtKB
  2. membrane coat Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Armadillo segment polarity proteinPRO_0000312833Add
BLAST

Proteomic databases

PRIDEiQ17GS9.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL002887-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17GS9.
SMRiQ17GS9. Positions 147-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 18540ARM 1Sequence AnalysisAdd
BLAST
Repeati188 – 22841ARM 2Sequence AnalysisAdd
BLAST
Repeati230 – 26940ARM 3Sequence AnalysisAdd
BLAST
Repeati272 – 31140ARM 4Sequence AnalysisAdd
BLAST
Repeati356 – 39540ARM 5Sequence AnalysisAdd
BLAST
Repeati397 – 43438ARM 6Sequence AnalysisAdd
BLAST
Repeati483 – 52442ARM 7Sequence AnalysisAdd
BLAST
Repeati594 – 63441ARM 8Sequence AnalysisAdd
BLAST
Repeati636 – 67540ARM 9Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence Analysis
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ17GS9.
KOiK02105.
OMAiRESHNRA.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ17GS9.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17GS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT
60 70 80 90 100
QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR
110 120 130 140 150
AAMFPETLEE GIEIPSTQFD PQQPTAVQRL SEPSQMLKHA VVNLINYQDD
160 170 180 190 200
ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV
210 220 230 240 250
AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS
260 270 280 290 300
SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
310 320 330 340 350
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK
360 370 380 390 400
VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV
410 420 430 440 450
DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE
460 470 480 490 500
ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNIV RNGYGLPVIV
510 520 530 540 550
KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL LVRLLFKAFQ
560 570 580 590 600
DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI
610 620 630 640 650
RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP
660 670 680 690 700
LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM
710 720 730 740 750
WNNGELGIGP DLQDILSPDQ AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP
760 770 780 790 800
IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA GGPPSGQPTS PYAMDMDVGE
810 820 830
MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL
Length:832
Mass (Da):90,307
Last modified:July 25, 2006 - v1
Checksum:i6331B575249EE484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1.
RefSeqiXP_001662670.1. XM_001662620.1.
UniGeneiAae.7915.

Genome annotation databases

EnsemblMetazoaiAAEL002887-RA; AAEL002887-PA; AAEL002887.
GeneIDi5576477.
KEGGiaag:AaeL_AAEL002887.
VectorBaseiAAEL002887. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1 .
RefSeqi XP_001662670.1. XM_001662620.1.
UniGenei Aae.7915.

3D structure databases

ProteinModelPortali Q17GS9.
SMRi Q17GS9. Positions 147-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL002887-PA.

Proteomic databases

PRIDEi Q17GS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL002887-RA ; AAEL002887-PA ; AAEL002887 .
GeneIDi 5576477.
KEGGi aag:AaeL_AAEL002887.
VectorBasei AAEL002887. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG297695.
HOGENOMi HOG000230958.
InParanoidi Q17GS9.
KOi K02105.
OMAi RESHNRA.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q17GS9.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 11 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiARM_AEDAE
AccessioniPrimary (citable) accession number: Q17GS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3