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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:armBy similarity
ORF Names:AAEL002887
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cell junctionadherens junction By similarity

  • Note: Inner surface of cell membrane and adherens junction.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Armadillo segment polarity proteinPRO_0000312833Add
BLAST

Proteomic databases

PRIDEiQ17GS9.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL002887-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17GS9.
SMRiQ17GS9. Positions 147-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 18540ARM 1Sequence AnalysisAdd
BLAST
Repeati188 – 22841ARM 2Sequence AnalysisAdd
BLAST
Repeati230 – 26940ARM 3Sequence AnalysisAdd
BLAST
Repeati272 – 31140ARM 4Sequence AnalysisAdd
BLAST
Repeati356 – 39540ARM 5Sequence AnalysisAdd
BLAST
Repeati397 – 43438ARM 6Sequence AnalysisAdd
BLAST
Repeati483 – 52442ARM 7Sequence AnalysisAdd
BLAST
Repeati594 – 63441ARM 8Sequence AnalysisAdd
BLAST
Repeati636 – 67540ARM 9Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence Analysis
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ17GS9.
KOiK02105.
OMAiWEQGFNQ.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ17GS9.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17GS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT
60 70 80 90 100
QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR
110 120 130 140 150
AAMFPETLEE GIEIPSTQFD PQQPTAVQRL SEPSQMLKHA VVNLINYQDD
160 170 180 190 200
ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV
210 220 230 240 250
AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS
260 270 280 290 300
SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
310 320 330 340 350
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK
360 370 380 390 400
VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV
410 420 430 440 450
DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE
460 470 480 490 500
ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNIV RNGYGLPVIV
510 520 530 540 550
KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL LVRLLFKAFQ
560 570 580 590 600
DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI
610 620 630 640 650
RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP
660 670 680 690 700
LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM
710 720 730 740 750
WNNGELGIGP DLQDILSPDQ AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP
760 770 780 790 800
IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA GGPPSGQPTS PYAMDMDVGE
810 820 830
MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL
Length:832
Mass (Da):90,307
Last modified:July 25, 2006 - v1
Checksum:i6331B575249EE484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1.
RefSeqiXP_001662670.1. XM_001662620.1.
UniGeneiAae.7915.

Genome annotation databases

EnsemblMetazoaiAAEL002887-RA; AAEL002887-PA; AAEL002887.
GeneIDi5576477.
KEGGiaag:AaeL_AAEL002887.
VectorBaseiAAEL002887. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1.
RefSeqiXP_001662670.1. XM_001662620.1.
UniGeneiAae.7915.

3D structure databases

ProteinModelPortaliQ17GS9.
SMRiQ17GS9. Positions 147-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL002887-PA.

Proteomic databases

PRIDEiQ17GS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL002887-RA; AAEL002887-PA; AAEL002887.
GeneIDi5576477.
KEGGiaag:AaeL_AAEL002887.
VectorBaseiAAEL002887. Aedes aegypti.

Organism-specific databases

CTDi5576477.

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ17GS9.
KOiK02105.
OMAiWEQGFNQ.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ17GS9.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiARM_AEDAE
AccessioniPrimary (citable) accession number: Q17GS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 25, 2006
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.