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Q17GS9

- ARM_AEDAE

UniProt

Q17GS9 - ARM_AEDAE

Protein

Armadillo segment polarity protein

Gene

arm

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

    GO - Molecular functioni

    1. cadherin binding Source: UniProtKB
    2. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. intracellular protein transport Source: InterPro
    3. neuroblast fate commitment Source: UniProtKB
    4. segment polarity determination Source: UniProtKB-KW
    5. vesicle-mediated transport Source: InterPro
    6. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Segmentation polarity protein

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo segment polarity protein
    Gene namesi
    Name:armBy similarity
    ORF Names:AAEL002887
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
    Note: Inner surface of cell membrane and adherens junction.By similarity

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB
    2. membrane coat Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Armadillo segment polarity proteinPRO_0000312833Add
    BLAST

    Proteomic databases

    PRIDEiQ17GS9.

    Interactioni

    Protein-protein interaction databases

    STRINGi7159.AAEL002887-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17GS9.
    SMRiQ17GS9. Positions 147-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati146 – 18540ARM 1Sequence AnalysisAdd
    BLAST
    Repeati188 – 22841ARM 2Sequence AnalysisAdd
    BLAST
    Repeati230 – 26940ARM 3Sequence AnalysisAdd
    BLAST
    Repeati272 – 31140ARM 4Sequence AnalysisAdd
    BLAST
    Repeati356 – 39540ARM 5Sequence AnalysisAdd
    BLAST
    Repeati397 – 43438ARM 6Sequence AnalysisAdd
    BLAST
    Repeati483 – 52442ARM 7Sequence AnalysisAdd
    BLAST
    Repeati594 – 63441ARM 8Sequence AnalysisAdd
    BLAST
    Repeati636 – 67540ARM 9Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Sequence Analysis
    Contains 9 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    HOGENOMiHOG000230958.
    KOiK02105.
    OMAiRESHNRA.
    OrthoDBiEOG7X9G6B.
    PhylomeDBiQ17GS9.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 11 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17GS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT    50
    QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR 100
    AAMFPETLEE GIEIPSTQFD PQQPTAVQRL SEPSQMLKHA VVNLINYQDD 150
    ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV 200
    AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS 250
    SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 300
    IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK 350
    VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV 400
    DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE 450
    ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNIV RNGYGLPVIV 500
    KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL LVRLLFKAFQ 550
    DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI 600
    RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP 650
    LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM 700
    WNNGELGIGP DLQDILSPDQ AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP 750
    IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA GGPPSGQPTS PYAMDMDVGE 800
    MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL 832
    Length:832
    Mass (Da):90,307
    Last modified:July 25, 2006 - v1
    Checksum:i6331B575249EE484
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH477256 Genomic DNA. Translation: EAT45858.1.
    RefSeqiXP_001662670.1. XM_001662620.1.
    UniGeneiAae.7915.

    Genome annotation databases

    EnsemblMetazoaiAAEL002887-RA; AAEL002887-PA; AAEL002887.
    GeneIDi5576477.
    KEGGiaag:AaeL_AAEL002887.
    VectorBaseiAAEL002887. Aedes aegypti.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH477256 Genomic DNA. Translation: EAT45858.1 .
    RefSeqi XP_001662670.1. XM_001662620.1.
    UniGenei Aae.7915.

    3D structure databases

    ProteinModelPortali Q17GS9.
    SMRi Q17GS9. Positions 147-676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7159.AAEL002887-PA.

    Proteomic databases

    PRIDEi Q17GS9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AAEL002887-RA ; AAEL002887-PA ; AAEL002887 .
    GeneIDi 5576477.
    KEGGi aag:AaeL_AAEL002887.
    VectorBasei AAEL002887. Aedes aegypti.

    Phylogenomic databases

    eggNOGi NOG297695.
    HOGENOMi HOG000230958.
    KOi K02105.
    OMAi RESHNRA.
    OrthoDBi EOG7X9G6B.
    PhylomeDBi Q17GS9.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 11 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
      Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
      , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
      Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LVPib12.

    Entry informationi

    Entry nameiARM_AEDAE
    AccessioniPrimary (citable) accession number: Q17GS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3