Armadillo segment polarity protein - Aedes aegypti (Yellowfever mosquito)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Armadillo segment polarity protein

Gene names

Name:	arm
ORF Names:	AAEL002887

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	832 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity. UniProtKB P18824

Subcellular location

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junction › adherens junction By similarity. Note: Inner surface of cell membrane and adherens junction By similarity. UniProtKB P18824

Sequence similarities

Belongs to the beta-catenin family.

Contains 9 ARM repeats.

Ontologies

Keywords
Biological process	Cell adhesion Wnt signaling pathway
Cellular component	Cell junction Cell membrane Cytoplasm Membrane
Domain	Repeat
Molecular function	Developmental protein Segmentation polarity protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW intracellular protein transport Inferred from electronic annotation. Source: InterPro neuroblast fate commitment Inferred from sequence or structural similarity. Source: UniProtKB segment polarity determination Inferred from electronic annotation. Source: UniProtKB-KW vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	adherens junction Inferred from sequence or structural similarity. Source: UniProtKB membrane coat Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cadherin binding Inferred from sequence or structural similarity. Source: UniProtKB transcription factor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 832

832

Armadillo segment polarity protein

PRO_0000312833

Regions

Repeat

146 – 185

40

ARM 1

Repeat

188 – 228

41

ARM 2

Repeat

230 – 269

40

ARM 3

Repeat

272 – 311

40

ARM 4

Repeat

356 – 395

40

ARM 5

Repeat

397 – 434

38

ARM 6

Repeat

483 – 524

42

ARM 7

Repeat

594 – 634

41

ARM 8

Repeat

636 – 675

40

ARM 9

Sequences

Sequence

Length

Mass (Da)

Tools

Q17GS9 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 6331B575249EE484
Show »

FASTA

832

90,307

        10         20         30         40         50         60 
MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT QVPSLSGKDD 

        70         80         90        100        110        120 
DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR AAMFPETLEE GIEIPSTQFD 

       130        140        150        160        170        180 
PQQPTAVQRL SEPSQMLKHA VVNLINYQDD ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV 

       190        200        210        220        230        240 
HQLSKKEASR HAIMNSPQMV AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG 

       250        260        270        280        290        300 
GIPALVKLLS SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 

       310        320        330        340        350        360 
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK VLSVCSSNKP 

       370        380        390        400        410        420 
AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV DGLETLLSGL VTVLGSSDVN 

       430        440        450        460        470        480 
VVTCAAGILS NLTCNNQRNK VTVCQVGGVE ALVGTIINAG DREEITEPAV CALRHLTSRH 

       490        500        510        520        530        540 
PESESAQNIV RNGYGLPVIV KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL 

       550        560        570        580        590        600 
LVRLLFKAFQ DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI 

       610        620        630        640        650        660 
RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP LTELLNSANE 

       670        680        690        700        710        720 
GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM WNNGELGIGP DLQDILSPDQ 

       730        740        750        760        770        780 
AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA 

       790        800        810        820        830 
GGPPSGQPTS PYAMDMDVGE MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL

« Hide

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector."
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.

Severson D.W.
Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477256 Genomic DNA. Translation: EAT45858.1.
RefSeq	XP_001662670.1. XM_001662620.1.
UniGene	Aae.7915.
3D structure databases
ProteinModelPortal	Q17GS9.
SMR	Q17GS9. Positions 147-676.
ModBase	Search...
Protein-protein interaction databases
STRING	7159.AAEL002887-PA.
Proteomic databases
PRIDE	Q17GS9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL002887-RA; AAEL002887-PA; AAEL002887.
GeneID	5576477.
KEGG	aag:AaeL_AAEL002887.
VectorBase	AAEL002887. Aedes aegypti.
Phylogenomic databases
eggNOG	NOG297695.
HOGENOM	HOG000230958.
KO	K02105.
OMA	QLSQTRS.
OrthoDB	EOG4WWQ0F.
PhylomeDB	Q17GS9.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR013284. Beta-catenin. IPR002553. Clathrin/coatomer_adapt-like_N. [Graphical view]
Pfam	PF01602. Adaptin_N. 1 hit. PF00514. Arm. 3 hits. [Graphical view]
PRINTS	PR01869. BCATNINFAMLY.
SMART	SM00185. ARM. 11 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 9 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARM_AEDAE

Accession

Primary (citable) accession number: Q17GS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	July 25, 2006
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents