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Q17GS9

- ARM_AEDAE

UniProt

Q17GS9 - ARM_AEDAE

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Protein
Armadillo segment polarity protein
Gene
arm, AAEL002887
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB
  2. cell adhesion Source: UniProtKB-KW
  3. intracellular protein transport Source: InterPro
  4. neuroblast fate commitment Source: UniProtKB
  5. segment polarity determination Source: UniProtKB-KW
  6. vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
ORF Names:AAEL002887
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction By similarity.By similarity

GO - Cellular componenti

  1. adherens junction Source: UniProtKB
  2. membrane coat Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Armadillo segment polarity protein
PRO_0000312833Add
BLAST

Proteomic databases

PRIDEiQ17GS9.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL002887-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17GS9.
SMRiQ17GS9. Positions 147-676.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 18540ARM 1
Add
BLAST
Repeati188 – 22841ARM 2
Add
BLAST
Repeati230 – 26940ARM 3
Add
BLAST
Repeati272 – 31140ARM 4
Add
BLAST
Repeati356 – 39540ARM 5
Add
BLAST
Repeati397 – 43438ARM 6
Add
BLAST
Repeati483 – 52442ARM 7
Add
BLAST
Repeati594 – 63441ARM 8
Add
BLAST
Repeati636 – 67540ARM 9
Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
KOiK02105.
OMAiRESHNRA.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ17GS9.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17GS9-1 [UniParc]FASTAAdd to Basket

« Hide

MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT    50
QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR 100
AAMFPETLEE GIEIPSTQFD PQQPTAVQRL SEPSQMLKHA VVNLINYQDD 150
ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV 200
AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS 250
SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 300
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK 350
VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV 400
DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE 450
ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNIV RNGYGLPVIV 500
KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL LVRLLFKAFQ 550
DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI 600
RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP 650
LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM 700
WNNGELGIGP DLQDILSPDQ AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP 750
IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA GGPPSGQPTS PYAMDMDVGE 800
MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL 832
Length:832
Mass (Da):90,307
Last modified:July 25, 2006 - v1
Checksum:i6331B575249EE484
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1.
RefSeqiXP_001662670.1. XM_001662620.1.
UniGeneiAae.7915.

Genome annotation databases

EnsemblMetazoaiAAEL002887-RA; AAEL002887-PA; AAEL002887.
GeneIDi5576477.
KEGGiaag:AaeL_AAEL002887.
VectorBaseiAAEL002887. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477256 Genomic DNA. Translation: EAT45858.1 .
RefSeqi XP_001662670.1. XM_001662620.1.
UniGenei Aae.7915.

3D structure databases

ProteinModelPortali Q17GS9.
SMRi Q17GS9. Positions 147-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL002887-PA.

Proteomic databases

PRIDEi Q17GS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL002887-RA ; AAEL002887-PA ; AAEL002887 .
GeneIDi 5576477.
KEGGi aag:AaeL_AAEL002887.
VectorBasei AAEL002887. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG297695.
HOGENOMi HOG000230958.
KOi K02105.
OMAi RESHNRA.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q17GS9.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 11 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiARM_AEDAE
AccessioniPrimary (citable) accession number: Q17GS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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