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Q17GM7

- CISY1_AEDAE

UniProt

Q17GM7 - CISY1_AEDAE

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Protein
Probable citrate synthase 1, mitochondrial
Gene
AAEL002956
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031 By similarity
Active sitei349 – 3491 By similarity
Active sitei404 – 4041 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase 1, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:AAEL002956
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 467Probable citrate synthase 1, mitochondrialPRO_0000291601
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PRIDEiQ17GM7.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi7159.AAEL002956-PA.

Structurei

3D structure databases

ProteinModelPortaliQ17GM7.
SMRiQ17GM7. Positions 30-463.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
KOiK01647.
OMAiMQKDSKF.
OrthoDBiEOG73BVCB.
PhylomeDBiQ17GM7.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17GM7-1 [UniParc]FASTAAdd to Basket

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MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV    50
KNFRKQFGAT KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI 100
PECQKVLPKA PGGAEPLPEG LFWLLITGDV PTKAQVDALS REWANRAALP 150
SHVVTMLNNM PTTLHPMSQL SCAVTALNHE SKYAKAYSEG VHKSKYWEYV 200
YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA NFTKMLGYED 250
EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG 300
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA 350
VLRKTDPRYT CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW 400
PNVDAHSGVL LQYYGLKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER 450
PKSMSTDGLM KAVGASK 467
Length:467
Mass (Da):51,657
Last modified:July 25, 2006 - v1
Checksum:i4033D11312107CB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477258 Genomic DNA. Translation: EAT45772.1.
RefSeqiXP_001656210.1. XM_001656160.1.
UniGeneiAae.20979.

Genome annotation databases

EnsemblMetazoaiAAEL002956-RA; AAEL002956-PA; AAEL002956.
GeneIDi5576704.
KEGGiaag:AaeL_AAEL002956.
VectorBaseiAAEL002956. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477258 Genomic DNA. Translation: EAT45772.1 .
RefSeqi XP_001656210.1. XM_001656160.1.
UniGenei Aae.20979.

3D structure databases

ProteinModelPortali Q17GM7.
SMRi Q17GM7. Positions 30-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL002956-PA.

Proteomic databases

PRIDEi Q17GM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL002956-RA ; AAEL002956-PA ; AAEL002956 .
GeneIDi 5576704.
KEGGi aag:AaeL_AAEL002956.
VectorBasei AAEL002956. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
KOi K01647.
OMAi MQKDSKF.
OrthoDBi EOG73BVCB.
PhylomeDBi Q17GM7.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiCISY1_AEDAE
AccessioniPrimary (citable) accession number: Q17GM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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