UniProtKB - Q17GM7 (CISY1_AEDAE)
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Protein
Probable citrate synthase 1, mitochondrial
Gene
AAEL002956
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Functioni
Miscellaneous
Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Catalytic activityi
Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Probable citrate synthase 2, mitochondrial (AAEL011789), Probable citrate synthase 1, mitochondrial (AAEL002956)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 303 | PROSITE-ProRule annotation | 1 | |
Active sitei | 349 | PROSITE-ProRule annotation | 1 | |
Active sitei | 404 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- citrate (Si)-synthase activity Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Tricarboxylic acid cycle |
Enzyme and pathway databases
UniPathwayi | UPA00223; UER00717. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:AAEL002956 |
Organismi | Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
Taxonomic identifieri | 7159 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291601 | ? – 467 | Probable citrate synthase 1, mitochondrial | ||
Transit peptidei | 1 – ? | MitochondrionSequence analysis |
Proteomic databases
PRIDEi | Q17GM7. |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
STRINGi | 7159.AAEL002956-PA. |
Structurei
3D structure databases
ProteinModelPortali | Q17GM7. |
SMRi | Q17GM7. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the citrate synthase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2617. Eukaryota. COG0372. LUCA. |
HOGENOMi | HOG000130831. |
InParanoidi | Q17GM7. |
OMAi | NCYPVLF. |
OrthoDBi | EOG091G068F. |
PhylomeDBi | Q17GM7. |
Family and domain databases
Gene3Di | 1.10.230.10. 1 hit. 1.10.580.10. 2 hits. |
InterProi | View protein in InterPro IPR016142. Citrate_synth-like_lrg_a-sub. IPR016143. Citrate_synth-like_sm_a-sub. IPR002020. Citrate_synthase. IPR019810. Citrate_synthase_AS. IPR010109. Citrate_synthase_euk. IPR036969. Citrate_synthase_sf. |
PANTHERi | PTHR11739. PTHR11739. 1 hit. |
Pfami | View protein in Pfam PF00285. Citrate_synt. 1 hit. |
PRINTSi | PR00143. CITRTSNTHASE. |
SUPFAMi | SSF48256. SSF48256. 1 hit. |
TIGRFAMsi | TIGR01793. cit_synth_euk. 1 hit. |
PROSITEi | View protein in PROSITE PS00480. CITRATE_SYNTHASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q17GM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV
60 70 80 90 100
KNFRKQFGAT KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI
110 120 130 140 150
PECQKVLPKA PGGAEPLPEG LFWLLITGDV PTKAQVDALS REWANRAALP
160 170 180 190 200
SHVVTMLNNM PTTLHPMSQL SCAVTALNHE SKYAKAYSEG VHKSKYWEYV
210 220 230 240 250
YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA NFTKMLGYED
260 270 280 290 300
EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGLKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER
460
PKSMSTDGLM KAVGASK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH477258 Genomic DNA. Translation: EAT45772.1. |
RefSeqi | XP_001656210.1. XM_001656160.1. |
Genome annotation databases
EnsemblMetazoai | AAEL002956-RA; AAEL002956-PA; AAEL002956. |
Similar proteinsi
Entry informationi
Entry namei | CISY1_AEDAE | |
Accessioni | Q17GM7Primary (citable) accession number: Q17GM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | July 25, 2006 | |
Last modified: | March 28, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |