AAEL002956

Functionⁱ

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityⁱ

Acetyl-CoA + H₂O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayⁱ: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Probable citrate synthase 2, mitochondrial (AAEL011789), Probable citrate synthase 1, mitochondrial (AAEL002956)
no protein annotated in this organism

This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	303	PROSITE-ProRule annotation	1
Active siteⁱ	349	PROSITE-ProRule annotation	1
Active siteⁱ	404	PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

citrate (Si)-synthase activity Source: UniProtKB

Complete GO annotation...

GO - Biological processⁱ

carbohydrate metabolic process Source: UniProtKB
tricarboxylic acid cycle Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Transferase
Biological process	Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayⁱ	UPA00223; UER00717.

UniPathwayⁱ

UPA00223; UER00717.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable citrate synthase 1, mitochondrial (EC:2.3.3.16)
Gene namesⁱ	ORF Names:AAEL002956
Organismⁱ	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifierⁱ	7159 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia
Proteomesⁱ	UP000008820 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Mitochondrion matrix By similarity

GO - Cellular componentⁱ

mitochondrial matrix Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000291601	? – 467	Probable citrate synthase 1, mitochondrial
Transit peptideⁱ	1 – ?	MitochondrionSequence analysis

Proteomic databases

PRIDEⁱ	Q17GM7.

PRIDEⁱ

Q17GM7.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	7159.AAEL002956-PA.

STRINGⁱ

7159.AAEL002956-PA.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q17GM7.
SMRⁱ	Q17GM7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the citrate synthase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2617. Eukaryota. COG0372. LUCA.
HOGENOMⁱ	HOG000130831.
InParanoidⁱ	Q17GM7.
KEGG Orthology (KO) More...KOⁱ	K01647.
OMAⁱ	RRIFKGG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G068F.
PhylomeDBⁱ	Q17GM7.

Family and domain databases

Gene3Dⁱ	1.10.230.10. 1 hit. 1.10.580.10. 2 hits.
InterProⁱ	View protein in InterPro IPR016142. Citrate_synth-like_lrg_a-sub. IPR016143. Citrate_synth-like_sm_a-sub. IPR002020. Citrate_synthase. IPR019810. Citrate_synthase_AS. IPR010109. Citrate_synthase_euk.
PANTHERⁱ	PTHR11739. PTHR11739. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00285. Citrate_synt. 1 hit.
PRINTSⁱ	PR00143. CITRTSNTHASE.
SUPFAMⁱ	SSF48256. SSF48256. 1 hit.
TIGRFAMsⁱ	TIGR01793. cit_synth_euk. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00480. CITRATE_SYNTHASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q17GM7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV 
        60         70         80         90        100
KNFRKQFGAT KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI 
       110        120        130        140        150
PECQKVLPKA PGGAEPLPEG LFWLLITGDV PTKAQVDALS REWANRAALP 
       160        170        180        190        200
SHVVTMLNNM PTTLHPMSQL SCAVTALNHE SKYAKAYSEG VHKSKYWEYV 
       210        220        230        240        250
YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA NFTKMLGYED 
       260        270        280        290        300
EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG 
       310        320        330        340        350
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA 
       360        370        380        390        400
VLRKTDPRYT CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW 
       410        420        430        440        450
PNVDAHSGVL LQYYGLKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER 
       460 
PKSMSTDGLM KAVGASK

Length:467

Mass (Da):51,657

Last modified:July 25, 2006 - v1

Checksum:ⁱ4033D11312107CB9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH477258 Genomic DNA. Translation: EAT45772.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001656210.1. XM_001656160.1.
UniGeneⁱ	Aae.20979.

Genome annotation databases

EnsemblMetazoaⁱ	AAEL002956-RA; AAEL002956-PA; AAEL002956.
GeneIDⁱ	5576704.
KEGGⁱ	aag:AaeL_AAEL002956.
VectorBaseⁱ	AAEL002956-RA; AAEL002956-PA; AAEL002956.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH477258 Genomic DNA. Translation: EAT45772.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001656210.1. XM_001656160.1.
UniGeneⁱ	Aae.20979.

3D structure databases

ProteinModelPortalⁱ	Q17GM7.
SMRⁱ	Q17GM7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	7159.AAEL002956-PA.

STRINGⁱ

7159.AAEL002956-PA.

Proteomic databases

PRIDEⁱ	Q17GM7.

PRIDEⁱ

Q17GM7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	AAEL002956-RA; AAEL002956-PA; AAEL002956.
GeneIDⁱ	5576704.
KEGGⁱ	aag:AaeL_AAEL002956.
VectorBaseⁱ	AAEL002956-RA; AAEL002956-PA; AAEL002956.

Organism-specific databases

CTDⁱ	5576704.

CTDⁱ

5576704.

Phylogenomic databases

eggNOGⁱ	KOG2617. Eukaryota. COG0372. LUCA.
HOGENOMⁱ	HOG000130831.
InParanoidⁱ	Q17GM7.
KEGG Orthology (KO) More...KOⁱ	K01647.
OMAⁱ	RRIFKGG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G068F.
PhylomeDBⁱ	Q17GM7.

Enzyme and pathway databases

UniPathwayⁱ	UPA00223; UER00717.

UniPathwayⁱ

UPA00223; UER00717.

Family and domain databases

Gene3Dⁱ	1.10.230.10. 1 hit. 1.10.580.10. 2 hits.
InterProⁱ	View protein in InterPro IPR016142. Citrate_synth-like_lrg_a-sub. IPR016143. Citrate_synth-like_sm_a-sub. IPR002020. Citrate_synthase. IPR019810. Citrate_synthase_AS. IPR010109. Citrate_synthase_euk.
PANTHERⁱ	PTHR11739. PTHR11739. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00285. Citrate_synt. 1 hit.
PRINTSⁱ	PR00143. CITRTSNTHASE.
SUPFAMⁱ	SSF48256. SSF48256. 1 hit.
TIGRFAMsⁱ	TIGR01793. cit_synth_euk. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00480. CITRATE_SYNTHASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CISY1_AEDAE
Accessionⁱ	Q17GM7Primary (citable) accession number: Q17GM7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	July 25, 2006
	Last modified:	June 7, 2017
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q17GM7 (CISY1_AEDAE)

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Probable citrate synthase 1, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: tricarboxylic acid cycle

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ