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Q17GM7 (CISY1_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable citrate synthase 1, mitochondrial
EC=2.3.3.1
Gene names
ORF Names:AAEL002956
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 467Probable citrate synthase 1, mitochondrialPRO_0000291601

Sites

Active site3031 By similarity
Active site3491 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17GM7 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 4033D11312107CB9

FASTA46751,657
        10         20         30         40         50         60 
MALSRIYSSK LASANKNLLP VITTYVRNAS DSTDLKAVLS EKIPKEQERV KNFRKQFGAT 

        70         80         90        100        110        120 
KVGEVTVDMM YGGMRGIKGL VCETSVLDPD EGIRFRGLSI PECQKVLPKA PGGAEPLPEG 

       130        140        150        160        170        180 
LFWLLITGDV PTKAQVDALS REWANRAALP SHVVTMLNNM PTTLHPMSQL SCAVTALNHE 

       190        200        210        220        230        240 
SKYAKAYSEG VHKSKYWEYV YEDSMDLIAK LPVVAATIYR NTYRDGKGIG AIDPKKDWSA 

       250        260        270        280        290        300 
NFTKMLGYED EQFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG 

       310        320        330        340        350        360 
PLHGLANQEV LVWLQKLRKE LGDNASEDKV KDFIWKTLKS GQVVPGYGHA VLRKTDPRYT 

       370        380        390        400        410        420 
CQREFALKHL PNDPLFQLVS NIYKVVPPIL TELGKVKNPW PNVDAHSGVL LQYYGLKEMN 

       430        440        450        460 
YYTVLFGVSR ALGVLASLVW DRALGLPIER PKSMSTDGLM KAVGASK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH477258 Genomic DNA. Translation: EAT45772.1.
RefSeqXP_001656210.1. XM_001656160.1.
UniGeneAae.20979.

3D structure databases

ProteinModelPortalQ17GM7.
SMRQ17GM7. Positions 30-463.
ModBaseSearch...

Protein-protein interaction databases

STRING7159.AAEL002956-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL002956-RA; AAEL002956-PA; AAEL002956.
GeneID5576704.
KEGGaag:AaeL_AAEL002956.
VectorBaseAAEL002956. Aedes aegypti.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000130831.
KOK01647.
OMADPGYTST.
OrthoDBEOG48KPSH.
PhylomeDBQ17GM7.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. Citrate_synthase_core. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY1_AEDAE
AccessionPrimary (citable) accession number: Q17GM7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 25, 2006
Last modified: April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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