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Q17967 (PDI1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase 1

Short name=PDI 1
EC=5.3.4.1
Alternative name(s):
Prolyl 4-hydroxylase subunit beta-1
Gene names
Name:pdi-1
ORF Names:C14B1.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 485465Protein disulfide-isomerase 1
PRO_0000034203

Regions

Domain21 – 130110Thioredoxin 1
Domain342 – 470129Thioredoxin 2
Motif482 – 4854Prevents secretion from ER Potential

Sites

Active site3931Nucleophile By similarity
Active site3961Nucleophile By similarity
Site3941Contributes to redox potential value By similarity
Site3951Contributes to redox potential value By similarity
Site4561Lowers pKa of C-terminal Cys of second active site By similarity

Amino acid modifications

Disulfide bond52 ↔ 55Redox-active By similarity
Disulfide bond393 ↔ 396Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17967 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 74070D655E6A415C

FASTA48553,436
        10         20         30         40         50         60 
MSLSVSFIFL LVASIGAVVA DSENVLVLTE SNFEETINGN EFVLVKFYAP WCVHCKSLAP 

        70         80         90        100        110        120 
KYDEAADLLK EEGSDIKLAK VDATENQALA SKFEVRGYPT ILYFKSGKPT KYTGGRATAQ 

       130        140        150        160        170        180 
IVDWVKKKSG PTVTTVESVE QLEELKGKTR VVVLGYFKDA KSDAATIYNE VADSVDDAFF 

       190        200        210        220        230        240 
AVAGSAEVAA AASLNEDGVA LIRTDGDDSE TSTIAEAEIT NTIALKQWLH AYKLSAVTEF 

       250        260        270        280        290        300 
THESAQEIVG GDLKKFHFLI IRKSDSSFDE TIAKFTEVAK KFRAKIVFVL LDVDVEENAR 

       310        320        330        340        350        360 
ILEFLGVDAK NTPANRIVSL ADQVEKFKPQ EGEDFEAFTN SYLEGKSAQD LKAQDLPEDW 

       370        380        390        400        410        420 
NALPVKVLVA SNFNEIALDE TKTVFVKFYA PWCGHCKQLV PVWDELAEKY ESNPNVVIAK 

       430        440        450        460        470        480 
LDATLNELAD VKVNSFPTLK LWPAGSSTPV DYDGDRNLEK FEEFVNKYAG SASESETASQ 


DHEEL 

« Hide

References

« Hide 'large scale' references
[1]"Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit."
Veijola J., Annunen P., Koivunen P., Page A.P., Pihlajaniemi T., Kivirikko K.I.
Biochem. J. 317:721-729(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95074 Genomic DNA. Translation: AAB94647.1.
Z37139 Genomic DNA. Translation: CAA85491.1.
PIRS71863.
RefSeqNP_497746.1. NM_065345.5.
UniGeneCel.23340.

3D structure databases

ProteinModelPortalQ17967.
SMRQ17967. Positions 21-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40712. 4 interactions.
DIPDIP-24653N.
IntActQ17967. 1 interaction.
MINTMINT-226883.
STRING6239.C14B1.1.2.

Proteomic databases

PaxDbQ17967.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC14B1.1.1; C14B1.1.1; C14B1.1.
C14B1.1.2; C14B1.1.2; C14B1.1.
GeneID175472.
KEGGcel:CELE_C14B1.1.
UCSCC14B1.1.1. c. elegans.

Organism-specific databases

CTD175472.
WormBaseC14B1.1; CE00897; WBGene00003962; pdi-1.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00740000115202.
HOGENOMHOG000162459.
InParanoidQ17967.
KOK09580.
OMAKPTKYTG.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
PRINTSPR00421. THIOREDOXIN.
SUPFAMSSF52833. SSF52833. 4 hits.
TIGRFAMsTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio888312.

Entry information

Entry namePDI1_CAEEL
AccessionPrimary (citable) accession number: Q17967
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase