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Protein

Protein disulfide-isomerase 1

Gene

pdi-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393NucleophileBy similarity1
Sitei394Contributes to redox potential valueBy similarity1
Sitei395Contributes to redox potential valueBy similarity1
Active sitei396NucleophileBy similarity1
Sitei456Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

  • protein disulfide isomerase activity Source: WormBase
  • protein-glutamine gamma-glutamyltransferase activity Source: WormBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase 1 (EC:5.3.4.1)
Short name:
PDI 1
Alternative name(s):
Prolyl 4-hydroxylase subunit beta-1
Gene namesi
Name:pdi-1
ORF Names:C14B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC14B1.1; CE00897; WBGene00003962; pdi-1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003420321 – 485Protein disulfide-isomerase 1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 55Redox-activePROSITE-ProRule annotation
Disulfide bondi393 ↔ 396Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ17967.
PaxDbiQ17967.
PeptideAtlasiQ17967.
PRIDEiQ17967.

Expressioni

Gene expression databases

BgeeiWBGene00003962.

Interactioni

Protein-protein interaction databases

BioGridi40712. 4 interactors.
DIPiDIP-24653N.
IntActiQ17967. 1 interactor.
MINTiMINT-226883.
STRINGi6239.C14B1.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ17967.
SMRiQ17967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 130Thioredoxin 1PROSITE-ProRule annotationAdd BLAST110
Domaini342 – 470Thioredoxin 2PROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi482 – 485Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000162459.
InParanoidiQ17967.
KOiK09580.
OMAiWPAGSST.
OrthoDBiEOG091G08WM.
PhylomeDBiQ17967.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSVSFIFL LVASIGAVVA DSENVLVLTE SNFEETINGN EFVLVKFYAP
60 70 80 90 100
WCVHCKSLAP KYDEAADLLK EEGSDIKLAK VDATENQALA SKFEVRGYPT
110 120 130 140 150
ILYFKSGKPT KYTGGRATAQ IVDWVKKKSG PTVTTVESVE QLEELKGKTR
160 170 180 190 200
VVVLGYFKDA KSDAATIYNE VADSVDDAFF AVAGSAEVAA AASLNEDGVA
210 220 230 240 250
LIRTDGDDSE TSTIAEAEIT NTIALKQWLH AYKLSAVTEF THESAQEIVG
260 270 280 290 300
GDLKKFHFLI IRKSDSSFDE TIAKFTEVAK KFRAKIVFVL LDVDVEENAR
310 320 330 340 350
ILEFLGVDAK NTPANRIVSL ADQVEKFKPQ EGEDFEAFTN SYLEGKSAQD
360 370 380 390 400
LKAQDLPEDW NALPVKVLVA SNFNEIALDE TKTVFVKFYA PWCGHCKQLV
410 420 430 440 450
PVWDELAEKY ESNPNVVIAK LDATLNELAD VKVNSFPTLK LWPAGSSTPV
460 470 480
DYDGDRNLEK FEEFVNKYAG SASESETASQ DHEEL
Length:485
Mass (Da):53,436
Last modified:November 1, 1996 - v1
Checksum:i74070D655E6A415C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95074 Genomic DNA. Translation: AAB94647.1.
Z37139 Genomic DNA. Translation: CAA85491.1.
PIRiS71863.
RefSeqiNP_497746.1. NM_065345.5.
UniGeneiCel.23340.

Genome annotation databases

EnsemblMetazoaiC14B1.1.1; C14B1.1.1; WBGene00003962.
C14B1.1.2; C14B1.1.2; WBGene00003962.
GeneIDi175472.
KEGGicel:CELE_C14B1.1.
UCSCiC14B1.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95074 Genomic DNA. Translation: AAB94647.1.
Z37139 Genomic DNA. Translation: CAA85491.1.
PIRiS71863.
RefSeqiNP_497746.1. NM_065345.5.
UniGeneiCel.23340.

3D structure databases

ProteinModelPortaliQ17967.
SMRiQ17967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40712. 4 interactors.
DIPiDIP-24653N.
IntActiQ17967. 1 interactor.
MINTiMINT-226883.
STRINGi6239.C14B1.1.2.

Proteomic databases

EPDiQ17967.
PaxDbiQ17967.
PeptideAtlasiQ17967.
PRIDEiQ17967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC14B1.1.1; C14B1.1.1; WBGene00003962.
C14B1.1.2; C14B1.1.2; WBGene00003962.
GeneIDi175472.
KEGGicel:CELE_C14B1.1.
UCSCiC14B1.1.1. c. elegans.

Organism-specific databases

CTDi175472.
WormBaseiC14B1.1; CE00897; WBGene00003962; pdi-1.

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000162459.
InParanoidiQ17967.
KOiK09580.
OMAiWPAGSST.
OrthoDBiEOG091G08WM.
PhylomeDBiQ17967.

Miscellaneous databases

PROiQ17967.

Gene expression databases

BgeeiWBGene00003962.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDI1_CAEEL
AccessioniPrimary (citable) accession number: Q17967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.