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Protein

Protein disulfide-isomerase 1

Gene

pdi-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393NucleophileBy similarity1
Sitei394Contributes to redox potential valueBy similarity1
Sitei395Contributes to redox potential valueBy similarity1
Active sitei396NucleophileBy similarity1
Sitei456Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

  • protein disulfide isomerase activity Source: WormBase
  • protein-glutamine gamma-glutamyltransferase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase 1 (EC:5.3.4.1)
Short name:
PDI 1
Alternative name(s):
Prolyl 4-hydroxylase subunit beta-1
Gene namesi
Name:pdi-1
ORF Names:C14B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC14B1.1 ; CE00897 ; WBGene00003962 ; pdi-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003420321 – 485Protein disulfide-isomerase 1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 55Redox-activePROSITE-ProRule annotation
Disulfide bondi393 ↔ 396Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ17967
PaxDbiQ17967
PeptideAtlasiQ17967
PRIDEiQ17967

Expressioni

Gene expression databases

BgeeiWBGene00003962

Interactioni

Protein-protein interaction databases

BioGridi40712, 4 interactors
DIPiDIP-24653N
IntActiQ17967, 2 interactors
MINTiQ17967
STRINGi6239.C14B1.1.2

Structurei

3D structure databases

ProteinModelPortaliQ17967
SMRiQ17967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 130Thioredoxin 1PROSITE-ProRule annotationAdd BLAST110
Domaini342 – 470Thioredoxin 2PROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi482 – 485Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000162459
InParanoidiQ17967
KOiK09580
OMAiFVLVKFY
OrthoDBiEOG091G08WM
PhylomeDBiQ17967

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSVSFIFL LVASIGAVVA DSENVLVLTE SNFEETINGN EFVLVKFYAP
60 70 80 90 100
WCVHCKSLAP KYDEAADLLK EEGSDIKLAK VDATENQALA SKFEVRGYPT
110 120 130 140 150
ILYFKSGKPT KYTGGRATAQ IVDWVKKKSG PTVTTVESVE QLEELKGKTR
160 170 180 190 200
VVVLGYFKDA KSDAATIYNE VADSVDDAFF AVAGSAEVAA AASLNEDGVA
210 220 230 240 250
LIRTDGDDSE TSTIAEAEIT NTIALKQWLH AYKLSAVTEF THESAQEIVG
260 270 280 290 300
GDLKKFHFLI IRKSDSSFDE TIAKFTEVAK KFRAKIVFVL LDVDVEENAR
310 320 330 340 350
ILEFLGVDAK NTPANRIVSL ADQVEKFKPQ EGEDFEAFTN SYLEGKSAQD
360 370 380 390 400
LKAQDLPEDW NALPVKVLVA SNFNEIALDE TKTVFVKFYA PWCGHCKQLV
410 420 430 440 450
PVWDELAEKY ESNPNVVIAK LDATLNELAD VKVNSFPTLK LWPAGSSTPV
460 470 480
DYDGDRNLEK FEEFVNKYAG SASESETASQ DHEEL
Length:485
Mass (Da):53,436
Last modified:November 1, 1996 - v1
Checksum:i74070D655E6A415C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95074 Genomic DNA Translation: AAB94647.1
Z37139 Genomic DNA Translation: CAA85491.1
PIRiS71863
RefSeqiNP_497746.1, NM_065345.5
UniGeneiCel.23340

Genome annotation databases

EnsemblMetazoaiC14B1.1.1; C14B1.1.1; WBGene00003962
C14B1.1.2; C14B1.1.2; WBGene00003962
GeneIDi175472
KEGGicel:CELE_C14B1.1
UCSCiC14B1.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPDI1_CAEEL
AccessioniPrimary (citable) accession number: Q17967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health