Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q17967

- PDI1_CAEEL

UniProt

Q17967 - PDI1_CAEEL

Protein

Protein disulfide-isomerase 1

Gene

pdi-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei393 – 3931NucleophileBy similarity
    Sitei394 – 3941Contributes to redox potential valueBy similarity
    Sitei395 – 3951Contributes to redox potential valueBy similarity
    Active sitei396 – 3961NucleophileBy similarity
    Sitei456 – 4561Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: WormBase
    2. protein-glutamine gamma-glutamyltransferase activity Source: WormBase

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. peptidyl-proline hydroxylation Source: GOC
    3. protein deglutathionylation Source: WormBase
    4. protein folding Source: GOC
    5. regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: RefGenome
    6. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase 1 (EC:5.3.4.1)
    Short name:
    PDI 1
    Alternative name(s):
    Prolyl 4-hydroxylase subunit beta-1
    Gene namesi
    Name:pdi-1
    ORF Names:C14B1.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC14B1.1; CE00897; WBGene00003962; pdi-1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 485465Protein disulfide-isomerase 1PRO_0000034203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 55Redox-activePROSITE-ProRule annotation
    Disulfide bondi393 ↔ 396Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ17967.

    Interactioni

    Protein-protein interaction databases

    BioGridi40712. 4 interactions.
    DIPiDIP-24653N.
    IntActiQ17967. 1 interaction.
    MINTiMINT-226883.
    STRINGi6239.C14B1.1.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17967.
    SMRiQ17967. Positions 21-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 130110Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 470129Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi482 – 4854Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00740000115202.
    HOGENOMiHOG000162459.
    InParanoidiQ17967.
    KOiK09580.
    OMAiWPAGSST.
    PhylomeDBiQ17967.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q17967-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSVSFIFL LVASIGAVVA DSENVLVLTE SNFEETINGN EFVLVKFYAP    50
    WCVHCKSLAP KYDEAADLLK EEGSDIKLAK VDATENQALA SKFEVRGYPT 100
    ILYFKSGKPT KYTGGRATAQ IVDWVKKKSG PTVTTVESVE QLEELKGKTR 150
    VVVLGYFKDA KSDAATIYNE VADSVDDAFF AVAGSAEVAA AASLNEDGVA 200
    LIRTDGDDSE TSTIAEAEIT NTIALKQWLH AYKLSAVTEF THESAQEIVG 250
    GDLKKFHFLI IRKSDSSFDE TIAKFTEVAK KFRAKIVFVL LDVDVEENAR 300
    ILEFLGVDAK NTPANRIVSL ADQVEKFKPQ EGEDFEAFTN SYLEGKSAQD 350
    LKAQDLPEDW NALPVKVLVA SNFNEIALDE TKTVFVKFYA PWCGHCKQLV 400
    PVWDELAEKY ESNPNVVIAK LDATLNELAD VKVNSFPTLK LWPAGSSTPV 450
    DYDGDRNLEK FEEFVNKYAG SASESETASQ DHEEL 485
    Length:485
    Mass (Da):53,436
    Last modified:November 1, 1996 - v1
    Checksum:i74070D655E6A415C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95074 Genomic DNA. Translation: AAB94647.1.
    Z37139 Genomic DNA. Translation: CAA85491.1.
    PIRiS71863.
    RefSeqiNP_497746.1. NM_065345.5.
    UniGeneiCel.23340.

    Genome annotation databases

    EnsemblMetazoaiC14B1.1.1; C14B1.1.1; WBGene00003962.
    C14B1.1.2; C14B1.1.2; WBGene00003962.
    GeneIDi175472.
    KEGGicel:CELE_C14B1.1.
    UCSCiC14B1.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95074 Genomic DNA. Translation: AAB94647.1 .
    Z37139 Genomic DNA. Translation: CAA85491.1 .
    PIRi S71863.
    RefSeqi NP_497746.1. NM_065345.5.
    UniGenei Cel.23340.

    3D structure databases

    ProteinModelPortali Q17967.
    SMRi Q17967. Positions 21-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40712. 4 interactions.
    DIPi DIP-24653N.
    IntActi Q17967. 1 interaction.
    MINTi MINT-226883.
    STRINGi 6239.C14B1.1.2.

    Proteomic databases

    PaxDbi Q17967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C14B1.1.1 ; C14B1.1.1 ; WBGene00003962 .
    C14B1.1.2 ; C14B1.1.2 ; WBGene00003962 .
    GeneIDi 175472.
    KEGGi cel:CELE_C14B1.1.
    UCSCi C14B1.1.1. c. elegans.

    Organism-specific databases

    CTDi 175472.
    WormBasei C14B1.1 ; CE00897 ; WBGene00003962 ; pdi-1.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00740000115202.
    HOGENOMi HOG000162459.
    InParanoidi Q17967.
    KOi K09580.
    OMAi WPAGSST.
    PhylomeDBi Q17967.

    Miscellaneous databases

    NextBioi 888312.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit."
      Veijola J., Annunen P., Koivunen P., Page A.P., Pihlajaniemi T., Kivirikko K.I.
      Biochem. J. 317:721-729(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDI1_CAEEL
    AccessioniPrimary (citable) accession number: Q17967
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3