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Q17967

- PDI1_CAEEL

UniProt

Q17967 - PDI1_CAEEL

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Protein

Protein disulfide-isomerase 1

Gene

pdi-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei393 – 3931NucleophileBy similarity
Sitei394 – 3941Contributes to redox potential valueBy similarity
Sitei395 – 3951Contributes to redox potential valueBy similarity
Active sitei396 – 3961NucleophileBy similarity
Sitei456 – 4561Lowers pKa of C-terminal Cys of second active siteBy similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: WormBase
  2. protein-glutamine gamma-glutamyltransferase activity Source: WormBase

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. peptidyl-proline hydroxylation Source: GOC
  3. protein deglutathionylation Source: WormBase
  4. protein folding Source: GOC
  5. regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: RefGenome
  6. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase 1 (EC:5.3.4.1)
Short name:
PDI 1
Alternative name(s):
Prolyl 4-hydroxylase subunit beta-1
Gene namesi
Name:pdi-1
ORF Names:C14B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC14B1.1; CE00897; WBGene00003962; pdi-1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 485465Protein disulfide-isomerase 1PRO_0000034203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 55Redox-activePROSITE-ProRule annotation
Disulfide bondi393 ↔ 396Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ17967.

Interactioni

Protein-protein interaction databases

BioGridi40712. 4 interactions.
DIPiDIP-24653N.
IntActiQ17967. 1 interaction.
MINTiMINT-226883.
STRINGi6239.C14B1.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ17967.
SMRiQ17967. Positions 21-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 130110Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini342 – 470129Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi482 – 4854Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00760000119201.
HOGENOMiHOG000162459.
InParanoidiQ17967.
KOiK09580.
OMAiWPAGSST.
PhylomeDBiQ17967.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17967-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSVSFIFL LVASIGAVVA DSENVLVLTE SNFEETINGN EFVLVKFYAP
60 70 80 90 100
WCVHCKSLAP KYDEAADLLK EEGSDIKLAK VDATENQALA SKFEVRGYPT
110 120 130 140 150
ILYFKSGKPT KYTGGRATAQ IVDWVKKKSG PTVTTVESVE QLEELKGKTR
160 170 180 190 200
VVVLGYFKDA KSDAATIYNE VADSVDDAFF AVAGSAEVAA AASLNEDGVA
210 220 230 240 250
LIRTDGDDSE TSTIAEAEIT NTIALKQWLH AYKLSAVTEF THESAQEIVG
260 270 280 290 300
GDLKKFHFLI IRKSDSSFDE TIAKFTEVAK KFRAKIVFVL LDVDVEENAR
310 320 330 340 350
ILEFLGVDAK NTPANRIVSL ADQVEKFKPQ EGEDFEAFTN SYLEGKSAQD
360 370 380 390 400
LKAQDLPEDW NALPVKVLVA SNFNEIALDE TKTVFVKFYA PWCGHCKQLV
410 420 430 440 450
PVWDELAEKY ESNPNVVIAK LDATLNELAD VKVNSFPTLK LWPAGSSTPV
460 470 480
DYDGDRNLEK FEEFVNKYAG SASESETASQ DHEEL
Length:485
Mass (Da):53,436
Last modified:November 1, 1996 - v1
Checksum:i74070D655E6A415C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95074 Genomic DNA. Translation: AAB94647.1.
Z37139 Genomic DNA. Translation: CAA85491.1.
PIRiS71863.
RefSeqiNP_497746.1. NM_065345.5.
UniGeneiCel.23340.

Genome annotation databases

EnsemblMetazoaiC14B1.1.1; C14B1.1.1; WBGene00003962.
C14B1.1.2; C14B1.1.2; WBGene00003962.
GeneIDi175472.
KEGGicel:CELE_C14B1.1.
UCSCiC14B1.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95074 Genomic DNA. Translation: AAB94647.1 .
Z37139 Genomic DNA. Translation: CAA85491.1 .
PIRi S71863.
RefSeqi NP_497746.1. NM_065345.5.
UniGenei Cel.23340.

3D structure databases

ProteinModelPortali Q17967.
SMRi Q17967. Positions 21-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40712. 4 interactions.
DIPi DIP-24653N.
IntActi Q17967. 1 interaction.
MINTi MINT-226883.
STRINGi 6239.C14B1.1.2.

Proteomic databases

PaxDbi Q17967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C14B1.1.1 ; C14B1.1.1 ; WBGene00003962 .
C14B1.1.2 ; C14B1.1.2 ; WBGene00003962 .
GeneIDi 175472.
KEGGi cel:CELE_C14B1.1.
UCSCi C14B1.1.1. c. elegans.

Organism-specific databases

CTDi 175472.
WormBasei C14B1.1 ; CE00897 ; WBGene00003962 ; pdi-1.

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00760000119201.
HOGENOMi HOG000162459.
InParanoidi Q17967.
KOi K09580.
OMAi WPAGSST.
PhylomeDBi Q17967.

Miscellaneous databases

NextBioi 888312.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit."
    Veijola J., Annunen P., Koivunen P., Page A.P., Pihlajaniemi T., Kivirikko K.I.
    Biochem. J. 317:721-729(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDI1_CAEEL
AccessioniPrimary (citable) accession number: Q17967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3