Q17963 (TG125_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein tag-125

Gene names

Name:	tag-125
ORF Names:	C14B1.4

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	determination of adult lifespan Inferred from mutant phenotype PubMed 20555324. Source: WormBase histone H3-K4 methylation Inferred from mutant phenotype PubMed 20555324. Source: WormBase
Cellular_component	nucleus Inferred from direct assay PubMed 17967446. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	WD repeat-containing protein tag-125		PRO_0000051503
Regions
	Repeat	85 – 115	31	WD 1
	Repeat	127 – 157	31	WD 2
	Repeat	169 – 199	31	WD 3
	Repeat	211 – 241	31	WD 4
	Repeat	254 – 284	31	WD 5
	Repeat	296 – 329	34	WD 6
	Repeat	341 – 373	33	WD 7

Sequences

	Sequence		Length	Mass (Da)
	Q17963 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3204DC36FE58FC19	FASTA	376	40,393
	10 20 30 40 50 60 MDTSENAASA AEQQPTQQID QLTVPNAPDG GSSAPAPSTS PNSISPSNPT GTPAPGASAQ 70 80 90 100 110 120 TPNPNAAGAS ASGSANYKLM CTLEGHTKSI SSAKFSPCGK YLGTSSADKT VKIWNMDHMI 130 140 150 160 170 180 CERTLTGHKL GVNDIAWSSD SRCVVSASDD KTLKIFEIVT SRMTKTLKGH NNYVFCCNFN 190 200 210 220 230 240 PQSSLVVSGS FDESVRIWDV KTGMCIKTLP AHSDPVSAVS FNRDGSLIAS GSYDGLVRIW 250 260 270 280 290 300 DTANGQCIKT LVDDENPPVA FVKFSPNGKY ILASNLDSTL KLWDFSKGKT LKQYTGHENS 310 320 330 340 350 360 KYCIFANFSV TGGKWIISGS EDCKIYIWNL QTREIVQCLE GHTQPVLASD CHPVQNIIAS 370 GALEPDNKIH IWRSDV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z37139 Genomic DNA. Translation: CAA85487.1.
PIR	T19266.
RefSeq	NP_497749.1. NM_065348.7.
3D structure databases
ProteinModelPortal	Q17963.
SMR	Q17963. Positions 43-375.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q17963. 1 interaction.
STRING	6239.C14B1.4.
Proteomic databases
PaxDb	Q17963.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C14B1.4; C14B1.4; C14B1.4.
GeneID	175474.
KEGG	cel:CELE_C14B1.4.
Organism-specific databases
CTD	175474.
WormBase	C14B1.4; CE00901; WBGene00006474; swd-3.1.
Phylogenomic databases
eggNOG	COG2319.
GeneTree	ENSGT00690000101787.
HOGENOM	HOG000091642.
InParanoid	Q17963.
KO	K14963.
OMA	KLWKSDT.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 5 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	888320.

Entry information

Entry name

TG125_CAEEL

Accession

Primary (citable) accession number: Q17963

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project