Q178N4 (Q178N4_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytosolic purine 5-nucleotidase EMBL EAT42656.1

Gene names

ORF Names:

AAEL005833, AaeL_AAEL005833 EMBL EAT42656.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium ion per subunit By similarity. PIRSR PIRSR017434-2

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR017434-2 Metal-binding PIRSR PIRSR017434-2
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	49	1	Nucleophile By similarity PIRSR PIRSR017434-1
	Active site	51	1	Proton donor By similarity PIRSR PIRSR017434-1
	Metal binding	49	1	Magnesium By similarity PIRSR PIRSR017434-2
	Metal binding	51	1	Magnesium; via carbonyl oxygen By similarity PIRSR PIRSR017434-2
	Metal binding	350	1	Magnesium By similarity PIRSR PIRSR017434-2

Sequences

	Sequence		Length	Mass (Da)
	Q178N4 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: CC2779F5A9A603E9	FASTA	551	63,537
	10 20 30 40 50 60 MSGIGIEERS WIHYRFDAIN YIQIHRNAKF QIFVNRSLHL ENIKFYGFDM DYTIAEYKSP 70 80 90 100 110 120 QYEQLGFNLV KERLVTLGYP VEILQFEYDP SFPVRGLWFD SLYGNLLKVD AYGNILVCVH 130 140 150 160 170 180 GFEFLKHSQV YELYPNKFLQ LDESRVYVLN TLFNLPETYL LACLVDFFTN SPQYAEQVDK 190 200 210 220 230 240 TGVKYGELFM SFRSIFQDVR GAVDWVHIYG DLKKKTLENL DEYVKKDERL PMVLSRIRES 250 260 270 280 290 300 GAKLFLLTNS DYNFTDRIMT FLFDFPHGAK PEEPHRDWKT YFDTIVVDAR KPLFFGEGTI 310 320 330 340 350 360 LRQVDTTTGA LRVGTHMGPL QVNQVYSGGS CDVFTKLIGA KGKDVLYVGD HIFGDILKSK 370 380 390 400 410 420 KIRGWRTFLI IPELVQELHV WTDKCQLFAE LQRLDVKLGD LYKNLDSSAK EKPDISSVRT 430 440 450 460 470 480 SIRDVTHKMD LAYGMMGSLF RSGSRQTFFS SQVVRYADLY AATILNLMYY PFSYMFRAPA 490 500 510 520 530 540 MLLPHESTVA HEQRFTLDAP MIQRTRSKNP GTPNDQPAAG VGVGGVEEDS KEVSILFDSV 550 TVFARIFANL F

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477361 Genomic DNA. Translation: EAT42656.1.
RefSeq	XP_001651490.1. XM_001651440.1.
UniGene	Aae.5484.
3D structure databases
ProteinModelPortal	Q178N4.
SMR	Q178N4. Positions 26-487.
ModBase	Search...
Protein-protein interaction databases
STRING	Q178N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL005833-RA; AAEL005833-PA; AAEL005833.
GeneID	5567111.
KEGG	aag:AaeL_AAEL005833.
VectorBase	AAEL005833. Aedes aegypti.
Phylogenomic databases
eggNOG	inNOG08195.
GeneTree	EMGT00050000017081.
OMA	EEEYMAL.
OrthoDB	EOG4B2RCB.
PhylomeDB	Q178N4.
Family and domain databases
InterPro	IPR023214. HAD-like_dom. IPR008380. HAD-SF_hydro_IG_5-nucl. IPR016695. Pur_nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01081.
PANTHER	PTHR12103. HAD-SF_hydro_IG_5-nucl. 1 hit.
Pfam	PF05761. 5_nucleotid. 1 hit. [Graphical view]
PIRSF	PIRSF017434. Purine_5'-nucleotidase. 1 hit.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02244. HAD-IG-Ncltidse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q178N4_AEDAE

Accession

Primary (citable) accession number: Q178N4

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)