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Q178E4 (Q178E4_AEDAE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:AAEL005931, AaeL_AAEL005931 EMBL EAT42557.1
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 176NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding35 – 373NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding77 – 793NADP By similarity PIRSR PIRSR000109-3
Region131 – 1333Substrate binding By similarity PIRSR PIRSR000109-2
Region188 – 1892Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1851Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1921Proton donor By similarity PIRSR PIRSR000109-1
Binding site1051NADP By similarity PIRSR PIRSR000109-3
Binding site1051Substrate By similarity PIRSR PIRSR000109-2
Binding site1931Substrate By similarity PIRSR PIRSR000109-2
Binding site2601Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2871Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q178E4 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 67B51E025EECFCA5

FASTA48253,057
        10         20         30         40         50         60 
MAEPKADIAL IGLAVMGQNL ILNMDSKGFV VCAYNRTVDK VKHFLDNEAK GTKIIGATSL 

        70         80         90        100        110        120 
QDMVNKLKTP RKIMLLVKAG SAVDDFINQL LPLIEKGDVI IDGGNSEHQD SARRYEELKA 

       130        140        150        160        170        180 
KGILYVGSGV SGGEEGARYG PSLMPGGHPD AWPLIKDIFQ AICAKSNGDP CCEWVGEGGA 

       190        200        210        220        230        240 
GHFVKMVHNG IEYGDMQLIC EAYHLMLALG MTQKEMAQEF DEWNKGVLDS FLIEITRDIL 

       250        260        270        280        290        300 
NYKDEEGYLL ERIRDTAGQK GTGKWTAIAA LHHGVPVTLI GEAVFARCLS ALKEERSKAS 

       310        320        330        340        350        360 
KQLSGPKVKA SVADRKAFLT HIRNALYCAK IVSYAQGFML LREAANEYKW NLNYGGIALM 

       370        380        390        400        410        420 
WRGGCIIRSV FLGNIRDAFV RNPQLSNLLL NDFFKDAIVS NQQSWREVVS HAVLWGVPVP 

       430        440        450        460        470        480 
AMSAALAFYD GYRSERLPAN LLQAQRDYFG AHTYELLGKE GKFVHTNWTG KGGNVSASTY 


LA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH477365 Genomic DNA. Translation: EAT42557.1.
RefSeqXP_001651702.1. XM_001651652.1.
UniGeneAae.11005.

3D structure databases

ProteinModelPortalQ178E4.
SMRQ178E4. Positions 5-473.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ178E4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL005931-RA; AAEL005931-PA; AAEL005931.
GeneID5567259.
KEGGaag:AaeL_AAEL005931.
VectorBaseAAEL005931. Aedes aegypti.

Phylogenomic databases

eggNOGinNOG06440.
GeneTreeEMGT00050000006696.
OMASNYPDTN.
OrthoDBEOG4SN040.
PhylomeDBQ178E4.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ178E4_AEDAE
AccessionPrimary (citable) accession number: Q178E4
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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