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Protein

Tyrosine-protein kinase receptor old-1

Gene

old-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase which plays a role in promoting longevity and resistance to stresses including UV irradiation and high temperatures, probably downstream of daf-16.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPPROSITE-ProRule annotation
Active sitei321 – 3211Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1899ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptor old-11 Publication (EC:2.7.10.1Curated)
Alternative name(s):
Overexpression longevity determinant protein 1Imported
Gene namesi
Name:old-1Imported
Synonyms:tkr-1Imported
ORF Names:C08H9.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC08H9.5; CE45789; WBGene00003862; old-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 5839ExtracellularSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 502423CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased life span and resistance to UV irradiation and high temperatures.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 502483Tyrosine-protein kinase receptor old-1CuratedPRO_0000434506Add
BLAST

Proteomic databases

PaxDbiQ17833.

Expressioni

Inductioni

By UV irradiation, high temperatures, starvation and old age.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.C08H9.5.

Structurei

3D structure databases

ProteinModelPortaliQ17833.
SMRiQ17833. Positions 148-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 473299Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00830000128295.
HOGENOMiHOG000017620.
InParanoidiQ17833.
OrthoDBiEOG77M8MX.
PhylomeDBiQ17833.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGTLIFVVF YSSYGFAHCN TILRSSSLSR NFEDSLRRIP RSTDKDETGF
60 70 80 90 100
EDSNVQEVIF ILLYCLFVAL AILICGLIIF YNSRKRELRA NRSRGDEYLL
110 120 130 140 150
EPTSADHKRR NSSNIVPPEP TPYPITSGES DLRQTPSRLS NVECPPELEL
160 170 180 190 200
APINEKIMYL HYYAEVEINE EDLDISKGRP LGSGEFGIIR KGFLRSKNSK
210 220 230 240 250
NEEKESRLEV AVKLPLNEYN QIQQELIYDE LKVMCAVGKH PNILALVGGI
260 270 280 290 300
TFGERKMIVS EFVENGDLLS FLRDNRIYFT NDQWTLETEQ DSLSLVDLLS
310 320 330 340 350
FAFQIAKGME YLIHVPCVHR DLALRNVLIK KNRIIRIADF GLARRHKNKD
360 370 380 390 400
YYKTQSVDTP LPIHWMAPES IDKLLFTQKS DVWSYGVCLY ELFSLGKSPY
410 420 430 440 450
ENVIKYDQRD FYWKYVLSYL NEGKRLAQPA HADAEIYNVM KLCWDLDMNS
460 470 480 490 500
RTTFLDCIEF FEKELKTTSN EYFLDLTRKL RSETNNQLRL SNWLSDEKHC

DS
Length:502
Mass (Da):58,385
Last modified:April 5, 2011 - v3
Checksum:i4606D76C554888B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA91146.3.
RefSeqiNP_496130.2. NM_063729.2.
UniGeneiCel.34571.

Genome annotation databases

EnsemblMetazoaiC08H9.5; C08H9.5; WBGene00003862.
GeneIDi191737.
KEGGicel:CELE_C08H9.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA91146.3.
RefSeqiNP_496130.2. NM_063729.2.
UniGeneiCel.34571.

3D structure databases

ProteinModelPortaliQ17833.
SMRiQ17833. Positions 148-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C08H9.5.

Proteomic databases

PaxDbiQ17833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC08H9.5; C08H9.5; WBGene00003862.
GeneIDi191737.
KEGGicel:CELE_C08H9.5.

Organism-specific databases

CTDi191737.
WormBaseiC08H9.5; CE45789; WBGene00003862; old-1.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00830000128295.
HOGENOMiHOG000017620.
InParanoidiQ17833.
OrthoDBiEOG77M8MX.
PhylomeDBiQ17833.

Miscellaneous databases

PROiQ17833.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene."
    Murakami S., Johnson T.E.
    Curr. Biol. 8:1091-1094(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans."
    Murakami S., Johnson T.E.
    Curr. Biol. 11:1517-1523(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiOLD1_CAEEL
AccessioniPrimary (citable) accession number: Q17833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.