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Q17820 (SAE1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SUMO-activating enzyme subunit aos-1
Gene names
Name:aos-1
ORF Names:C08B6.9
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The dimeric enzyme acts as a E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 Probable. Ref.2 Ref.3

Pathway

Protein modification; protein sumoylation.

Subunit structure

Heterodimer of aos-1 and uba-2.

Sequence similarities

Belongs to the ubiquitin-activating E1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343SUMO-activating enzyme subunit aos-1
PRO_0000270189

Sequences

Sequence LengthMass (Da)Tools
Q17820 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2897C0F918E881B6

FASTA34338,738
        10         20         30         40         50         60 
MEVSKAEQAI YDRQIRLWGM EAQNKIRNSK VLIIGGKQLG AEVAKTLSLA GVDEMHLVDH 

        70         80         90        100        110        120 
RLVDTEEIGM NFLYDASVDN SKMTKWAASY NFLYNLNRNV KLFIVEEDVL SKNDSEIEEY 

       130        140        150        160        170        180 
LTKFTLVVVL DESYERTAKV NNICRKHHIR FISGAIYGWI GYAFFDFDGH AYLVKAKSPD 

       190        200        210        220        230        240 
CLNEEESETG KTSTVVTVDE EFVLETFSYP SFVETLNSDF TAKKIVRKCK RIVPTSYFLV 

       250        260        270        280        290        300 
KSMLRASSEN KLTGVTENDI EKLIPIWNEE VAAGNHTIDM QPVQPDRFDH LFGPNFGPTA 

       310        320        330        340 
ACVGGVIGQE AIKSISEGKN PLRNLFIYTG FESTGFMCNF PPV 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins."
Jones D., Crowe E., Stevens T.A., Candido E.P.M.
Genome Biol. 3:RESEARCH0002.1-RESEARCH0002.15(2002) [PubMed: 11806825] [Abstract]
Cited for: FUNCTION.
[3]"SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2."
Zhang H., Smolen G.A., Palmer R., Christoforou A., van den Heuvel S., Haber D.A.
Nat. Genet. 36:507-511(2004) [PubMed: 15107848] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72502 Genomic DNA. Translation: CAA96591.1.
PIRT19082.
RefSeqNP_505604.1. NM_073203.3.
UniGeneCel.30581.

3D structure databases

HSSPHSSP built from PDB template 1Y8Q based on UniProtKB Q9UBE0.
ProteinModelPortalQ17820.
SMRQ17820. Positions 2-342.
ModBaseSearch...

Protein-protein interaction databases

IntActQ17820. 2 interactions.
STRINGQ17820.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC08B6.9.1; C08B6.9.1; C08B6.9.
C08B6.9.2; C08B6.9.2; C08B6.9.
GeneID179409.
KEGGcel:C08B6.9.
NMPDRfig|6239.3.peg.19316.
UCSCC08B6.9. c. elegans.

Organism-specific databases

CTD179409.
WormBaseC08B6.9; CE05246; WBGene00000142; aos-1.

Phylogenomic databases

eggNOGmeNOG08011.
GeneTreeEMGT00050000009512.
HOGENOMHBG385819.
InParanoidQ17820.
OMAIALYDRQ.
PhylomeDBQ17820.

Gene expression databases

ArrayExpressQ17820.

Family and domain databases

InterProIPR009036. Molybdenum_cofac_synth_MoeB.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK10684.
PfamPF00899. ThiF. 1 hit.
[Graphical view]
SUPFAMSSF69572. MoeB. 1 hit.
ProtoNetSearch...

Other

NextBio905268.

Entry information

Entry nameSAE1_CAEEL
AccessionPrimary (citable) accession number: Q17820
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families