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Protein

Nuclear hormone receptor family member nhr-35

Gene

nhr-35

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi74 – 149Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri77 – 97NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri113 – 137NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-35
Gene namesi
Name:nhr-35
ORF Names:C07A12.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC07A12.3a; CE30855; WBGene00003628; nhr-35.
C07A12.3b; CE38483; WBGene00003628; nhr-35.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537781 – 542Nuclear hormone receptor family member nhr-35Add BLAST542

Proteomic databases

EPDiQ17771.
PaxDbiQ17771.
PeptideAtlasiQ17771.

PTM databases

iPTMnetiQ17771.

Expressioni

Gene expression databases

BgeeiWBGene00003628.

Interactioni

Protein-protein interaction databases

BioGridi45660. 3 interactors.
MINTiMINT-1067889.
STRINGi6239.C07A12.3a.

Structurei

3D structure databases

ProteinModelPortaliQ17771.
SMRiQ17771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 438NR LBDPROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 97NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri113 – 137NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000020288.
InParanoidiQ17771.
OMAiCHICSDV.
OrthoDBiEOG091G0A89.
PhylomeDBiQ17771.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR035500. NHR_like_dom_sf.
IPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS51843. NR_LBD. 1 hit.
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q17771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNKIHAGFT FTPSHARSLD CFVCLLVLFS FRSTPPHGRH PAIEPTLLIS
60 70 80 90 100
HYYRGQMLGT YNGDSKAETD GKDNSICHIC SDVATGRHYG AIACNGCKGF
110 120 130 140 150
FRRTVRRNYE YHCRFESKCE IDKHNRAVCR YCRFMKCISS GMRDDQVQSE
160 170 180 190 200
RDVIGKREKK DNMKTYCQDP TPRTSPELTM SPVEDEYDQL LESLLKSEMT
210 220 230 240 250
IQSLRDTVIT QTGNVEYTTK SKNRLSHTDR TATLNDVLKS MHSQLLLVIE
260 270 280 290 300
WAKTLPEFKQ LSGADQAVLL KNFAGQHVTL CVAYRSVGAN DALKLLNDLY
310 320 330 340 350
IPRASKTTPH LKEYVDGFYL RDCEKVMDQL VEPMRFLKLD NKEFVALKAC
360 370 380 390 400
VLFNPVAPGL SNHAVNLVLN ARRKIFAAFE KYVRVNKPLE TTRVGDLTFF
410 420 430 440 450
ILTPLSVLSK SISEDIMFTK VSGVARIDVL MEELILAETD YGEDRQDQTP
460 470 480 490 500
CSIMNDTPSG SQDMCSPCPE DLLRTSTSSN SPTNSSLTAG LLLKTDDAMM
510 520 530 540
SGIGTQYTTP QPHTPQFADS SHLNLPYAPF TSSYNQYPNT YS
Length:542
Mass (Da):60,984
Last modified:March 15, 2004 - v3
Checksum:i285D1ED277B61DB3
GO
Isoform b (identifier: Q17771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):54,676
Checksum:i09C19A84B67260E9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0201601 – 56Missing in isoform b. CuratedAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080373 Genomic DNA. Translation: CCD63275.1.
FO080373 Genomic DNA. Translation: CCD63276.1.
AF273781 mRNA. Translation: AAG15130.1.
RefSeqiNP_001024365.1. NM_001029194.2. [Q17771-1]
NP_001024366.1. NM_001029195.3.
UniGeneiCel.19470.

Genome annotation databases

EnsemblMetazoaiC07A12.3a; C07A12.3a; WBGene00003628. [Q17771-1]
GeneIDi180725.
KEGGicel:CELE_C07A12.3.
UCSCiC07A12.3a.2. c. elegans. [Q17771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNHR35_CAEEL
AccessioniPrimary (citable) accession number: Q17771
Secondary accession number(s): Q3Y408, Q9GTH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 15, 2004
Last modified: January 31, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families