Q17761 (6PGD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating
EC=1.1.1.44

Gene names

ORF Names:

T25B9.9

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.
Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090067
Regions
	Nucleotide binding	10 – 15	6	NADP By similarity
	Nucleotide binding	33 – 35	3	NADP By similarity
	Nucleotide binding	75 – 77	3	NADP By similarity
	Region	129 – 131	3	Substrate binding By similarity
	Region	186 – 187	2	Substrate binding By similarity
Sites
	Active site	183	1	Proton acceptor By similarity
	Active site	190	1	Proton donor By similarity
	Binding site	103	1	NADP By similarity
	Binding site	103	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity
	Binding site	260	1	Substrate; via amide nitrogen By similarity
	Binding site	287	1	Substrate By similarity
	Binding site	448	1	Substrate; shared with dimeric partner By similarity
	Binding site	454	1	Substrate; shared with dimeric partner By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q17761 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: D3CF6F1065F17535	FASTA	484	53,196
	10 20 30 40 50 60 MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTVKLVD DFLANEAKGT KIIGAHSIEE 70 80 90 100 110 120 MCKKLKRPRR VMMLIKAGTP VDMMIDAIVP HLEEGDIIID GGNSEYTDSN RRSEQLAAKG 130 140 150 160 170 180 IMFVGCGVSG GEEGARFGPS LMPGGNPKAW PHLKDIFQKI AAKSNGEPCC DWVGNAGSGH 190 200 210 220 230 240 FVKMVHNGIE YGDMQLIAEA YHLLSKAVEL NHDQMAEVLD DWNKGELESF LIEITANILK 250 260 270 280 290 300 YRDEQGEPIV PKIRDSAGQK GTGKWTCFAA LEYGLPVTLI GEAVFARCLS ALKDERVRAS 310 320 330 340 350 360 KQLPRPQVSP DTVVQDKRVF IKQISKALYA SKIVSYAQGF MLLAEASKQF NWNLNFGAIA 370 380 390 400 410 420 LMWRGGCIIR SRFLGDIEHA FQKNKQLSNL LLDDFFTKAI TEAQDSWRVV VCAAVRLGIP 430 440 450 460 470 480 VPAFSSALAF YDGYTSEVVP ANLLQAQRDY FGAHTYELLA KPGTWVHTNW TGTGGRVTSN AYNA

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z70311, Z70306 Genomic DNA. Translation: CAA94380.1.
PIR	T19020.
RefSeq	NP_501998.1. NM_069597.5.
UniGene	Cel.6711.
3D structure databases
ProteinModelPortal	Q17761.
SMR	Q17761. Positions 2-475.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.T25B9.9.2.
Proteomic databases
PaxDb	Q17761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T25B9.9.1; T25B9.9.1; T25B9.9. T25B9.9.2; T25B9.9.2; T25B9.9.
GeneID	177971.
KEGG	cel:CELE_T25B9.9.
UCSC	T25B9.9.1. c. elegans.
Organism-specific databases
CTD	177971.
WormBase	T25B9.9; CE06508; WBGene00012015.
Phylogenomic databases
eggNOG	COG0362.
GeneTree	ENSGT00390000009023.
HOGENOM	HOG000255147.
InParanoid	Q17761.
KO	K00033.
OMA	KQQIGVI.
Enzyme and pathway databases
UniPathway	UPA00115; UER00410.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 1.20.5.320. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NADP-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PIRSF	PIRSF000109. 6PGD. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	899182.

Entry information

Entry name

6PGD_CAEEL

Accession

Primary (citable) accession number: Q17761
Secondary accession number(s): Q22772

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project