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Q17761

- 6PGD_CAEEL

UniProt

Q17761 - 6PGD_CAEEL

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

T25B9.9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031NADPBy similarity
    Binding sitei103 – 1031SubstrateBy similarity
    Active sitei183 – 1831Proton acceptorBy similarity
    Active sitei190 – 1901Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei260 – 2601Substrate; via amide nitrogenBy similarity
    Binding sitei287 – 2871SubstrateBy similarity
    Binding sitei448 – 4481Substrate; shared with dimeric partnerBy similarity
    Binding sitei454 – 4541Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPBy similarity
    Nucleotide bindingi33 – 353NADPBy similarity
    Nucleotide bindingi75 – 773NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    ORF Names:T25B9.9
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiT25B9.9; CE06508; WBGene00012015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090067Add
    BLAST

    Proteomic databases

    PaxDbiQ17761.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.T25B9.9.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17761.
    SMRiQ17761. Positions 2-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1313Substrate bindingBy similarity
    Regioni186 – 1872Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    GeneTreeiENSGT00390000009023.
    HOGENOMiHOG000255147.
    InParanoidiQ17761.
    KOiK00033.
    OMAiRTPERTK.
    PhylomeDBiQ17761.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17761-1 [UniParc]FASTAAdd to Basket

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    MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTVKLVD DFLANEAKGT    50
    KIIGAHSIEE MCKKLKRPRR VMMLIKAGTP VDMMIDAIVP HLEEGDIIID 100
    GGNSEYTDSN RRSEQLAAKG IMFVGCGVSG GEEGARFGPS LMPGGNPKAW 150
    PHLKDIFQKI AAKSNGEPCC DWVGNAGSGH FVKMVHNGIE YGDMQLIAEA 200
    YHLLSKAVEL NHDQMAEVLD DWNKGELESF LIEITANILK YRDEQGEPIV 250
    PKIRDSAGQK GTGKWTCFAA LEYGLPVTLI GEAVFARCLS ALKDERVRAS 300
    KQLPRPQVSP DTVVQDKRVF IKQISKALYA SKIVSYAQGF MLLAEASKQF 350
    NWNLNFGAIA LMWRGGCIIR SRFLGDIEHA FQKNKQLSNL LLDDFFTKAI 400
    TEAQDSWRVV VCAAVRLGIP VPAFSSALAF YDGYTSEVVP ANLLQAQRDY 450
    FGAHTYELLA KPGTWVHTNW TGTGGRVTSN AYNA 484
    Length:484
    Mass (Da):53,196
    Last modified:November 1, 1998 - v2
    Checksum:iD3CF6F1065F17535
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70311, Z70306 Genomic DNA. Translation: CAA94380.1.
    PIRiT19020.
    RefSeqiNP_501998.1. NM_069597.5.
    UniGeneiCel.6711.

    Genome annotation databases

    EnsemblMetazoaiT25B9.9; T25B9.9; WBGene00012015.
    GeneIDi177971.
    KEGGicel:CELE_T25B9.9.
    UCSCiT25B9.9.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70311 , Z70306 Genomic DNA. Translation: CAA94380.1 .
    PIRi T19020.
    RefSeqi NP_501998.1. NM_069597.5.
    UniGenei Cel.6711.

    3D structure databases

    ProteinModelPortali Q17761.
    SMRi Q17761. Positions 2-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T25B9.9.2.

    Proteomic databases

    PaxDbi Q17761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T25B9.9 ; T25B9.9 ; WBGene00012015 .
    GeneIDi 177971.
    KEGGi cel:CELE_T25B9.9.
    UCSCi T25B9.9.1. c. elegans.

    Organism-specific databases

    CTDi 177971.
    WormBasei T25B9.9 ; CE06508 ; WBGene00012015 .

    Phylogenomic databases

    eggNOGi COG0362.
    GeneTreei ENSGT00390000009023.
    HOGENOMi HOG000255147.
    InParanoidi Q17761.
    KOi K00033.
    OMAi RTPERTK.
    PhylomeDBi Q17761.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Miscellaneous databases

    NextBioi 899182.
    PROi Q17761.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry namei6PGD_CAEEL
    AccessioniPrimary (citable) accession number: Q17761
    Secondary accession number(s): Q22772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3