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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

T25B9.9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADPBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Active sitei183 – 1831Proton acceptorBy similarity
Active sitei190 – 1901Proton donorBy similarity
Binding sitei191 – 1911SubstrateBy similarity
Binding sitei260 – 2601Substrate; via amide nitrogenBy similarity
Binding sitei287 – 2871SubstrateBy similarity
Binding sitei448 – 4481Substrate; shared with dimeric partnerBy similarity
Binding sitei454 – 4541Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPBy similarity
Nucleotide bindingi33 – 353NADPBy similarity
Nucleotide bindingi75 – 773NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_261919. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
ORF Names:T25B9.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiT25B9.9; CE06508; WBGene00012015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090067Add
BLAST

Proteomic databases

PaxDbiQ17761.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.T25B9.9.2.

Structurei

3D structure databases

ProteinModelPortaliQ17761.
SMRiQ17761. Positions 2-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Substrate bindingBy similarity
Regioni186 – 1872Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
GeneTreeiENSGT00390000009023.
HOGENOMiHOG000255147.
InParanoidiQ17761.
KOiK00033.
OMAiKYHLNWS.
PhylomeDBiQ17761.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17761-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTVKLVD DFLANEAKGT
60 70 80 90 100
KIIGAHSIEE MCKKLKRPRR VMMLIKAGTP VDMMIDAIVP HLEEGDIIID
110 120 130 140 150
GGNSEYTDSN RRSEQLAAKG IMFVGCGVSG GEEGARFGPS LMPGGNPKAW
160 170 180 190 200
PHLKDIFQKI AAKSNGEPCC DWVGNAGSGH FVKMVHNGIE YGDMQLIAEA
210 220 230 240 250
YHLLSKAVEL NHDQMAEVLD DWNKGELESF LIEITANILK YRDEQGEPIV
260 270 280 290 300
PKIRDSAGQK GTGKWTCFAA LEYGLPVTLI GEAVFARCLS ALKDERVRAS
310 320 330 340 350
KQLPRPQVSP DTVVQDKRVF IKQISKALYA SKIVSYAQGF MLLAEASKQF
360 370 380 390 400
NWNLNFGAIA LMWRGGCIIR SRFLGDIEHA FQKNKQLSNL LLDDFFTKAI
410 420 430 440 450
TEAQDSWRVV VCAAVRLGIP VPAFSSALAF YDGYTSEVVP ANLLQAQRDY
460 470 480
FGAHTYELLA KPGTWVHTNW TGTGGRVTSN AYNA
Length:484
Mass (Da):53,196
Last modified:November 1, 1998 - v2
Checksum:iD3CF6F1065F17535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70311, Z70306 Genomic DNA. Translation: CAA94380.1.
PIRiT19020.
RefSeqiNP_501998.1. NM_069597.5.
UniGeneiCel.6711.

Genome annotation databases

EnsemblMetazoaiT25B9.9; T25B9.9; WBGene00012015.
GeneIDi177971.
KEGGicel:CELE_T25B9.9.
UCSCiT25B9.9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70311, Z70306 Genomic DNA. Translation: CAA94380.1.
PIRiT19020.
RefSeqiNP_501998.1. NM_069597.5.
UniGeneiCel.6711.

3D structure databases

ProteinModelPortaliQ17761.
SMRiQ17761. Positions 2-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T25B9.9.2.

Proteomic databases

PaxDbiQ17761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT25B9.9; T25B9.9; WBGene00012015.
GeneIDi177971.
KEGGicel:CELE_T25B9.9.
UCSCiT25B9.9.1. c. elegans.

Organism-specific databases

CTDi177971.
WormBaseiT25B9.9; CE06508; WBGene00012015.

Phylogenomic databases

eggNOGiCOG0362.
GeneTreeiENSGT00390000009023.
HOGENOMiHOG000255147.
InParanoidiQ17761.
KOiK00033.
OMAiKYHLNWS.
PhylomeDBiQ17761.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.
ReactomeiREACT_261919. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi899182.
PROiQ17761.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry namei6PGD_CAEEL
AccessioniPrimary (citable) accession number: Q17761
Secondary accession number(s): Q22772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.