Reviewed,
UniProtKB/Swiss-Prot Q17761 (6PGD_CAEEL)
Last modified
February 9, 2010.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating EC=1.1.1.44 | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 484 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the 6-phosphogluconate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Gluconate utilization Pentose shunt |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW embryonic development ending in birth or egg hatchingInferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticleInferred from mutant phenotype. Source: WormBase nematode larval developmentInferred from mutant phenotype. Source: WormBase oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 484 | 484 | 6-phosphogluconate dehydrogenase, decarboxylating | PRO_0000090067 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z70311, Z70306 Genomic DNA. Translation: CAA94380.1. Z70306, Z70311 Genomic DNA. Translation: CAA94326.1. |
| PIR | T19020. |
| RefSeq | NP_501998.1. |
| UniGene | Cel.6711 |
3D structure databases | |
| SMR | Q17761. Positions 2-475. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q17761. |
Genome annotation databases | |
| Ensembl | T25B9.9.1; T25B9.9.1; T25B9.9; Caenorhabditis elegans. [Genome view] T25B9.9.2; T25B9.9.2; T25B9.9; Caenorhabditis elegans. [Genome view] |
| GeneID | 177971. |
| KEGG | cel:T25B9.9. |
| UCSC | T25B9.9.1. c. elegans. |
Organism-specific databases | |
| CTD | 177971. |
| WormBase | WBGene00012015. T25B9.9. |
| WormPep | T25B9.9. CE06508. [WorfDB] |
Phylogenomic databases | |
| eggNOG | meNOG05305. |
| HOGENOM | HBG286913. |
| InParanoid | Q17761. |
| OMA | GQKEAYD. |
| PhylomeDB | Q17761. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.44. 672. |
Gene expression databases | |
| ArrayExpress | Q17761. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| PRINTS | PR00076. 6PGDHDRGNASE. |
| TIGRFAMs | TIGR00873. gnd. 1 hit. |
| PROSITE | PS00461. 6PGD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 899182. |
Entry information
| Entry name | 6PGD_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q17761 Secondary accession number(s): Q22772 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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