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Q17761 (6PGD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating

EC=1.1.1.44
Gene names
ORF Names:T25B9.9
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4844846-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090067

Regions

Nucleotide binding10 – 156NADP By similarity
Nucleotide binding33 – 353NADP By similarity
Nucleotide binding75 – 773NADP By similarity
Region129 – 1313Substrate binding By similarity
Region186 – 1872Substrate binding By similarity

Sites

Active site1831Proton acceptor By similarity
Active site1901Proton donor By similarity
Binding site1031NADP By similarity
Binding site1031Substrate By similarity
Binding site1911Substrate By similarity
Binding site2601Substrate; via amide nitrogen By similarity
Binding site2871Substrate By similarity
Binding site4481Substrate; shared with dimeric partner By similarity
Binding site4541Substrate; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17761 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: D3CF6F1065F17535

FASTA48453,196
        10         20         30         40         50         60 
MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTVKLVD DFLANEAKGT KIIGAHSIEE 

        70         80         90        100        110        120 
MCKKLKRPRR VMMLIKAGTP VDMMIDAIVP HLEEGDIIID GGNSEYTDSN RRSEQLAAKG 

       130        140        150        160        170        180 
IMFVGCGVSG GEEGARFGPS LMPGGNPKAW PHLKDIFQKI AAKSNGEPCC DWVGNAGSGH 

       190        200        210        220        230        240 
FVKMVHNGIE YGDMQLIAEA YHLLSKAVEL NHDQMAEVLD DWNKGELESF LIEITANILK 

       250        260        270        280        290        300 
YRDEQGEPIV PKIRDSAGQK GTGKWTCFAA LEYGLPVTLI GEAVFARCLS ALKDERVRAS 

       310        320        330        340        350        360 
KQLPRPQVSP DTVVQDKRVF IKQISKALYA SKIVSYAQGF MLLAEASKQF NWNLNFGAIA 

       370        380        390        400        410        420 
LMWRGGCIIR SRFLGDIEHA FQKNKQLSNL LLDDFFTKAI TEAQDSWRVV VCAAVRLGIP 

       430        440        450        460        470        480 
VPAFSSALAF YDGYTSEVVP ANLLQAQRDY FGAHTYELLA KPGTWVHTNW TGTGGRVTSN 


AYNA 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70311, Z70306 Genomic DNA. Translation: CAA94380.1.
PIRT19020.
RefSeqNP_501998.1. NM_069597.5.
UniGeneCel.6711.

3D structure databases

ProteinModelPortalQ17761.
SMRQ17761. Positions 2-475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T25B9.9.2.

Proteomic databases

PaxDbQ17761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT25B9.9.1; T25B9.9.1; T25B9.9.
T25B9.9.2; T25B9.9.2; T25B9.9.
GeneID177971.
KEGGcel:CELE_T25B9.9.
UCSCT25B9.9.1. c. elegans.

Organism-specific databases

CTD177971.
WormBaseT25B9.9; CE06508; WBGene00012015.

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHOG000255147.
InParanoidQ17761.
KOK00033.
OMAKYHLNWS.
PhylomeDBQ17761.

Enzyme and pathway databases

UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio899182.
PROQ17761.

Entry information

Entry name6PGD_CAEEL
AccessionPrimary (citable) accession number: Q17761
Secondary accession number(s): Q22772
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase