ID   MTHR_CAEEL              Reviewed;         663 AA.
AC   Q17693;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Probable methylenetetrahydrofolate reductase;
DE            EC=1.5.1.20;
GN   ORFNames=C06A8.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-
CC       methylenetetrahydrofolate + NAD(P)H.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate pathway.
CC   -!- INTERACTION:
CC       Q9NGT3:mdf-2; NbExp=1; IntAct=EBI-313786, EBI-328699;
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family.
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DR   EMBL; U39849; AAA81048.2; -; Genomic_DNA.
DR   PIR; T15423; T15423.
DR   RefSeq; NP_741027.1; -.
DR   UniGene; Cel.17243; -.
DR   HSSP; P00394; 1B5T.
DR   IntAct; Q17693; 3.
DR   PRIDE; Q17693; -.
DR   Ensembl; C06A8.1; Caenorhabditis elegans.
DR   GeneID; 174254; -.
DR   KEGG; cel:C06A8.1; -.
DR   WormBase; WBGene00015512; C06A8.1.
DR   WormPep; C06A8.1; CE30593.
DR   OMA; Q17693; DITWHPA.
DR   BRENDA; 1.5.1.20; 672.
DR   NextBio; 883243; -.
DR   ArrayExpress; Q17693; -.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NADPH)...; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   Pfam; PF02219; MTHFR; 1.
DR   TIGRFAMs; TIGR00677; fadh2_euk; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; FAD; Flavoprotein; NADP; Oxidoreductase.
FT   CHAIN         1    663       Probable methylenetetrahydrofolate
FT                                reductase.
FT                                /FTId=PRO_0000190248.
SQ   SEQUENCE   663 AA;  75487 MW;  EA94806A2C3BC1CD CRC64;
     MTNTGETKVI ESHGTIKKID SLSTMPYCGV ETDENAVVEE KITLESGKSW SPKHYELLHE
     RIERLIDEKQ QFFSLEFFPP RFVNGVPNFL ERVERLSEGG SVFVDMTWHM GSDPANVDKV
     TSSSSIAASM LDYCGVDTML HMTCVQYNKA DTLKHLEQAK AMGLRSILAL RGDLPPGTEL
     EDTHQFRALD MIRWIREEYG NYFSIGCAGY PLGHPQAPSY KADLMYLKAK CDAGANFVIT
     QLFFEAETFE KFVRDCREIG ITQPIIPGIM PIMGYESIKR IAKLSQLEIP QHILDDLEPI
     KHDDDAVQKY GTERCIEMCR RLLDNGTAPS IHLYTMNREG SIREILKSLG LWKLEGDRVF
     PWKNRSQHPI RCLESVRPIY WSFRPRSYIT RTRDWDQFPN GRWGNSSSPA FGDVSSYYLS
     NLTTVRNADD RLAMFGANIE SFEDVKRVFI NYITQAPNAD GVKVTVLPWT EAETGVQPET
     SLISEQLVWC NENGILTVNS QPSVNGAPST DPLVGWGKPG GYCYQKAYLE CFMTAELSDK
     LIQIIEREFP VRVNYHAINK DSTFDKTNSE ETTPIAVTWG VFPGSEIAQP TVVDPLSFRA
     WRDEAYQMWM AQWGDFYPKE SKSYGVIKAV HDEFRLVTLV DNDFQKPSVL FDVLQKALDE
     LKK
//