Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q17693

- MTHR_CAEEL

UniProt

Q17693 - MTHR_CAEEL

Protein

Probable methylenetetrahydrofolate reductase

Gene

C06A8.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton donor/acceptorBy similarity
    Binding sitei141 – 1411FADBy similarity
    Binding sitei173 – 1731SubstrateBy similarity
    Binding sitei210 – 2101FADBy similarity
    Binding sitei223 – 2231FADBy similarity
    Binding sitei230 – 2301FADBy similarity
    Binding sitei241 – 2411SubstrateBy similarity
    Binding sitei334 – 3341SubstrateBy similarity
    Binding sitei338 – 3381SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi76 – 816NADBy similarity
    Nucleotide bindingi107 – 1082NAD and FADBy similarity
    Nucleotide bindingi171 – 1733FADBy similarity
    Nucleotide bindingi214 – 2174FADBy similarity

    GO - Molecular functioni

    1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

    GO - Biological processi

    1. methionine metabolic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable methylenetetrahydrofolate reductase (EC:1.5.1.20)
    Gene namesi
    ORF Names:C06A8.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC06A8.1a; CE30593; WBGene00015512.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663Probable methylenetetrahydrofolate reductasePRO_0000190248Add
    BLAST

    Proteomic databases

    PaxDbiQ17693.
    PRIDEiQ17693.

    Interactioni

    Protein-protein interaction databases

    BioGridi39587. 3 interactions.
    DIPiDIP-26125N.
    IntActiQ17693. 3 interactions.
    MINTiMINT-212490.
    STRINGi6239.C06A8.1a.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17693.
    SMRiQ17693. Positions 72-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0685.
    GeneTreeiENSGT00390000012490.
    HOGENOMiHOG000246234.
    InParanoidiQ17693.
    KOiK00297.
    OMAiYLEFFVS.
    PhylomeDBiQ17693.

    Family and domain databases

    Gene3Di3.20.20.220. 1 hit.
    InterProiIPR029041. FAD-linked_oxidoreductase-like.
    IPR004621. Fadh2_euk.
    IPR003171. Mehydrof_redctse.
    [Graphical view]
    PfamiPF02219. MTHFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF51730. SSF51730. 1 hit.
    TIGRFAMsiTIGR00677. fadh2_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q17693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNTGETKVI ESHGTIKKID SLSTMPYCGV ETDENAVVEE KITLESGKSW    50
    SPKHYELLHE RIERLIDEKQ QFFSLEFFPP RFVNGVPNFL ERVERLSEGG 100
    SVFVDMTWHM GSDPANVDKV TSSSSIAASM LDYCGVDTML HMTCVQYNKA 150
    DTLKHLEQAK AMGLRSILAL RGDLPPGTEL EDTHQFRALD MIRWIREEYG 200
    NYFSIGCAGY PLGHPQAPSY KADLMYLKAK CDAGANFVIT QLFFEAETFE 250
    KFVRDCREIG ITQPIIPGIM PIMGYESIKR IAKLSQLEIP QHILDDLEPI 300
    KHDDDAVQKY GTERCIEMCR RLLDNGTAPS IHLYTMNREG SIREILKSLG 350
    LWKLEGDRVF PWKNRSQHPI RCLESVRPIY WSFRPRSYIT RTRDWDQFPN 400
    GRWGNSSSPA FGDVSSYYLS NLTTVRNADD RLAMFGANIE SFEDVKRVFI 450
    NYITQAPNAD GVKVTVLPWT EAETGVQPET SLISEQLVWC NENGILTVNS 500
    QPSVNGAPST DPLVGWGKPG GYCYQKAYLE CFMTAELSDK LIQIIEREFP 550
    VRVNYHAINK DSTFDKTNSE ETTPIAVTWG VFPGSEIAQP TVVDPLSFRA 600
    WRDEAYQMWM AQWGDFYPKE SKSYGVIKAV HDEFRLVTLV DNDFQKPSVL 650
    FDVLQKALDE LKK 663
    Length:663
    Mass (Da):75,487
    Last modified:June 20, 2002 - v2
    Checksum:iEA94806A2C3BC1CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080131 Genomic DNA. Translation: CCD61458.1.
    PIRiT15423.
    RefSeqiNP_741027.1. NM_171024.4.
    UniGeneiCel.17243.

    Genome annotation databases

    EnsemblMetazoaiC06A8.1a; C06A8.1a; WBGene00015512.
    GeneIDi174254.
    KEGGicel:CELE_C06A8.1.
    UCSCiC06A8.1a.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080131 Genomic DNA. Translation: CCD61458.1 .
    PIRi T15423.
    RefSeqi NP_741027.1. NM_171024.4.
    UniGenei Cel.17243.

    3D structure databases

    ProteinModelPortali Q17693.
    SMRi Q17693. Positions 72-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39587. 3 interactions.
    DIPi DIP-26125N.
    IntActi Q17693. 3 interactions.
    MINTi MINT-212490.
    STRINGi 6239.C06A8.1a.2.

    Proteomic databases

    PaxDbi Q17693.
    PRIDEi Q17693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C06A8.1a ; C06A8.1a ; WBGene00015512 .
    GeneIDi 174254.
    KEGGi cel:CELE_C06A8.1.
    UCSCi C06A8.1a.1. c. elegans.

    Organism-specific databases

    CTDi 174254.
    WormBasei C06A8.1a ; CE30593 ; WBGene00015512 .

    Phylogenomic databases

    eggNOGi COG0685.
    GeneTreei ENSGT00390000012490.
    HOGENOMi HOG000246234.
    InParanoidi Q17693.
    KOi K00297.
    OMAi YLEFFVS.
    PhylomeDBi Q17693.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Miscellaneous databases

    NextBioi 883243.
    PROi Q17693.

    Family and domain databases

    Gene3Di 3.20.20.220. 1 hit.
    InterProi IPR029041. FAD-linked_oxidoreductase-like.
    IPR004621. Fadh2_euk.
    IPR003171. Mehydrof_redctse.
    [Graphical view ]
    Pfami PF02219. MTHFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51730. SSF51730. 1 hit.
    TIGRFAMsi TIGR00677. fadh2_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMTHR_CAEEL
    AccessioniPrimary (citable) accession number: Q17693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3