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Q17693

- MTHR_CAEEL

UniProt

Q17693 - MTHR_CAEEL

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Protein

Probable methylenetetrahydrofolate reductase

Gene
C06A8.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton donor/acceptor By similarity
Binding sitei141 – 1411FAD By similarity
Binding sitei173 – 1731Substrate By similarity
Binding sitei210 – 2101FAD By similarity
Binding sitei223 – 2231FAD By similarity
Binding sitei230 – 2301FAD By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei334 – 3341Substrate By similarity
Binding sitei338 – 3381Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 816NAD By similarity
Nucleotide bindingi107 – 1082NAD and FAD By similarity
Nucleotide bindingi171 – 1733FAD By similarity
Nucleotide bindingi214 – 2174FAD By similarity

GO - Molecular functioni

  1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

GO - Biological processi

  1. methionine metabolic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylenetetrahydrofolate reductase (EC:1.5.1.20)
Gene namesi
ORF Names:C06A8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC06A8.1a; CE30593; WBGene00015512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Probable methylenetetrahydrofolate reductasePRO_0000190248Add
BLAST

Proteomic databases

PaxDbiQ17693.
PRIDEiQ17693.

Interactioni

Protein-protein interaction databases

BioGridi39587. 3 interactions.
DIPiDIP-26125N.
IntActiQ17693. 3 interactions.
MINTiMINT-212490.
STRINGi6239.C06A8.1a.2.

Structurei

3D structure databases

ProteinModelPortaliQ17693.
SMRiQ17693. Positions 72-351.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0685.
GeneTreeiENSGT00390000012490.
HOGENOMiHOG000246234.
InParanoidiQ17693.
KOiK00297.
OMAiYLEFFVS.
PhylomeDBiQ17693.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR004621. Fadh2_euk.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.
TIGRFAMsiTIGR00677. fadh2_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17693-1 [UniParc]FASTAAdd to Basket

« Hide

MTNTGETKVI ESHGTIKKID SLSTMPYCGV ETDENAVVEE KITLESGKSW    50
SPKHYELLHE RIERLIDEKQ QFFSLEFFPP RFVNGVPNFL ERVERLSEGG 100
SVFVDMTWHM GSDPANVDKV TSSSSIAASM LDYCGVDTML HMTCVQYNKA 150
DTLKHLEQAK AMGLRSILAL RGDLPPGTEL EDTHQFRALD MIRWIREEYG 200
NYFSIGCAGY PLGHPQAPSY KADLMYLKAK CDAGANFVIT QLFFEAETFE 250
KFVRDCREIG ITQPIIPGIM PIMGYESIKR IAKLSQLEIP QHILDDLEPI 300
KHDDDAVQKY GTERCIEMCR RLLDNGTAPS IHLYTMNREG SIREILKSLG 350
LWKLEGDRVF PWKNRSQHPI RCLESVRPIY WSFRPRSYIT RTRDWDQFPN 400
GRWGNSSSPA FGDVSSYYLS NLTTVRNADD RLAMFGANIE SFEDVKRVFI 450
NYITQAPNAD GVKVTVLPWT EAETGVQPET SLISEQLVWC NENGILTVNS 500
QPSVNGAPST DPLVGWGKPG GYCYQKAYLE CFMTAELSDK LIQIIEREFP 550
VRVNYHAINK DSTFDKTNSE ETTPIAVTWG VFPGSEIAQP TVVDPLSFRA 600
WRDEAYQMWM AQWGDFYPKE SKSYGVIKAV HDEFRLVTLV DNDFQKPSVL 650
FDVLQKALDE LKK 663
Length:663
Mass (Da):75,487
Last modified:June 20, 2002 - v2
Checksum:iEA94806A2C3BC1CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080131 Genomic DNA. Translation: CCD61458.1.
PIRiT15423.
RefSeqiNP_741027.1. NM_171024.4.
UniGeneiCel.17243.

Genome annotation databases

EnsemblMetazoaiC06A8.1a; C06A8.1a; WBGene00015512.
GeneIDi174254.
KEGGicel:CELE_C06A8.1.
UCSCiC06A8.1a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080131 Genomic DNA. Translation: CCD61458.1 .
PIRi T15423.
RefSeqi NP_741027.1. NM_171024.4.
UniGenei Cel.17243.

3D structure databases

ProteinModelPortali Q17693.
SMRi Q17693. Positions 72-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39587. 3 interactions.
DIPi DIP-26125N.
IntActi Q17693. 3 interactions.
MINTi MINT-212490.
STRINGi 6239.C06A8.1a.2.

Proteomic databases

PaxDbi Q17693.
PRIDEi Q17693.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C06A8.1a ; C06A8.1a ; WBGene00015512 .
GeneIDi 174254.
KEGGi cel:CELE_C06A8.1.
UCSCi C06A8.1a.1. c. elegans.

Organism-specific databases

CTDi 174254.
WormBasei C06A8.1a ; CE30593 ; WBGene00015512 .

Phylogenomic databases

eggNOGi COG0685.
GeneTreei ENSGT00390000012490.
HOGENOMi HOG000246234.
InParanoidi Q17693.
KOi K00297.
OMAi YLEFFVS.
PhylomeDBi Q17693.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Miscellaneous databases

NextBioi 883243.
PROi Q17693.

Family and domain databases

Gene3Di 3.20.20.220. 1 hit.
InterProi IPR029041. FAD-linked_oxidoreductase-like.
IPR004621. Fadh2_euk.
IPR003171. Mehydrof_redctse.
[Graphical view ]
Pfami PF02219. MTHFR. 1 hit.
[Graphical view ]
SUPFAMi SSF51730. SSF51730. 1 hit.
TIGRFAMsi TIGR00677. fadh2_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMTHR_CAEEL
AccessioniPrimary (citable) accession number: Q17693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 20, 2002
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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