Q17693 (MTHR_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 76.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable methylenetetrahydrofolate reductase EC=1.5.1.20 | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 663 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the methylenetetrahydrofolate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | methionine metabolic process Inferred from electronic annotation. Source: InterPro positive regulation of growth rateInferred from mutant phenotype. Source: WormBase |
| Molecular function | methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 663 | 663 | Probable methylenetetrahydrofolate reductase | PRO_0000190248 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | FO080131 Genomic DNA. Translation: CCD61458.1. |
| PIR | T15423. |
| RefSeq | NP_741027.1. NM_171024.3. |
| UniGene | Cel.17243. |
3D structure databases | |
| ProteinModelPortal | Q17693. |
| SMR | Q17693. Positions 61-353. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-26125N. |
| IntAct | Q17693. 3 interactions. |
| MINT | MINT-212490. |
| STRING | Q17693. |
Proteomic databases | |
| PRIDE | Q17693. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | C06A8.1a.1; C06A8.1a.1; C06A8.1. C06A8.1a.2; C06A8.1a.2; C06A8.1. |
| GeneID | 174254. |
| KEGG | cel:C06A8.1. |
| UCSC | C06A8.1a.1. c. elegans. |
Organism-specific databases | |
| CTD | 174254. |
| WormBase | C06A8.1a; CE30593; WBGene00015512. |
Phylogenomic databases | |
| eggNOG | meNOG04108. |
| GeneTree | EMGT00050000016904. |
| HOGENOM | HBG649727. |
| InParanoid | Q17693. |
| OMA | WIEDPRR. |
| PhylomeDB | Q17693. |
Gene expression databases | |
| ArrayExpress | Q17693. |
Family and domain databases | |
| InterPro | IPR004621. Fadh2_euk. IPR003171. Mehydrof_redctse. [Graphical view] |
| KO | K00297. |
| Pfam | PF02219. MTHFR. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00677. Fadh2_euk. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 883243. |
Entry information
| Entry name | MTHR_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q17693 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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