Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q17693 (MTHR_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable methylenetetrahydrofolate reductase

EC=1.5.1.20
Gene names
ORF Names:C06A8.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

Cofactor

FAD By similarity.

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Sequence similarities

Belongs to the methylenetetrahydrofolate reductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Probable methylenetetrahydrofolate reductase
PRO_0000190248

Regions

Nucleotide binding76 – 816NAD By similarity
Nucleotide binding107 – 1082NAD and FAD By similarity
Nucleotide binding171 – 1733FAD By similarity
Nucleotide binding214 – 2174FAD By similarity

Sites

Active site761Proton donor/acceptor By similarity
Binding site1411FAD By similarity
Binding site1731Substrate By similarity
Binding site2101FAD By similarity
Binding site2231FAD By similarity
Binding site2301FAD By similarity
Binding site2411Substrate By similarity
Binding site3341Substrate By similarity
Binding site3381Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q17693 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: EA94806A2C3BC1CD

FASTA66375,487
        10         20         30         40         50         60 
MTNTGETKVI ESHGTIKKID SLSTMPYCGV ETDENAVVEE KITLESGKSW SPKHYELLHE 

        70         80         90        100        110        120 
RIERLIDEKQ QFFSLEFFPP RFVNGVPNFL ERVERLSEGG SVFVDMTWHM GSDPANVDKV 

       130        140        150        160        170        180 
TSSSSIAASM LDYCGVDTML HMTCVQYNKA DTLKHLEQAK AMGLRSILAL RGDLPPGTEL 

       190        200        210        220        230        240 
EDTHQFRALD MIRWIREEYG NYFSIGCAGY PLGHPQAPSY KADLMYLKAK CDAGANFVIT 

       250        260        270        280        290        300 
QLFFEAETFE KFVRDCREIG ITQPIIPGIM PIMGYESIKR IAKLSQLEIP QHILDDLEPI 

       310        320        330        340        350        360 
KHDDDAVQKY GTERCIEMCR RLLDNGTAPS IHLYTMNREG SIREILKSLG LWKLEGDRVF 

       370        380        390        400        410        420 
PWKNRSQHPI RCLESVRPIY WSFRPRSYIT RTRDWDQFPN GRWGNSSSPA FGDVSSYYLS 

       430        440        450        460        470        480 
NLTTVRNADD RLAMFGANIE SFEDVKRVFI NYITQAPNAD GVKVTVLPWT EAETGVQPET 

       490        500        510        520        530        540 
SLISEQLVWC NENGILTVNS QPSVNGAPST DPLVGWGKPG GYCYQKAYLE CFMTAELSDK 

       550        560        570        580        590        600 
LIQIIEREFP VRVNYHAINK DSTFDKTNSE ETTPIAVTWG VFPGSEIAQP TVVDPLSFRA 

       610        620        630        640        650        660 
WRDEAYQMWM AQWGDFYPKE SKSYGVIKAV HDEFRLVTLV DNDFQKPSVL FDVLQKALDE 


LKK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080131 Genomic DNA. Translation: CCD61458.1.
PIRT15423.
RefSeqNP_741027.1. NM_171024.4.
UniGeneCel.17243.

3D structure databases

ProteinModelPortalQ17693.
SMRQ17693. Positions 72-351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39587. 3 interactions.
DIPDIP-26125N.
IntActQ17693. 3 interactions.
MINTMINT-212490.
STRING6239.C06A8.1a.2.

Proteomic databases

PaxDbQ17693.
PRIDEQ17693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC06A8.1a.1; C06A8.1a.1; C06A8.1.
C06A8.1a.2; C06A8.1a.2; C06A8.1.
GeneID174254.
KEGGcel:CELE_C06A8.1.
UCSCC06A8.1a.1. c. elegans.

Organism-specific databases

CTD174254.
WormBaseC06A8.1a; CE30593; WBGene00015512.

Phylogenomic databases

eggNOGCOG0685.
HOGENOMHOG000246234.
InParanoidQ17693.
KOK00297.
OMAYLEFFVS.
PhylomeDBQ17693.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

InterProIPR004621. Fadh2_euk.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamPF02219. MTHFR. 1 hit.
[Graphical view]
TIGRFAMsTIGR00677. fadh2_euk. 1 hit.
ProtoNetSearch...

Other

NextBio883243.
PROQ17693.

Entry information

Entry nameMTHR_CAEEL
AccessionPrimary (citable) accession number: Q17693
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 20, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase