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Protein

Thioredoxin domain-containing protein C06A6.5

Gene

C06A6.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein C06A6.5
Gene namesi
ORF Names:C06A6.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC06A6.5 ; CE27661 ; WBGene00015510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025058722 – 413Thioredoxin domain-containing protein C06A6.5Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ17688
PaxDbiQ17688
PeptideAtlasiQ17688
PRIDEiQ17688

PTM databases

iPTMnetiQ17688

Expressioni

Gene expression databases

BgeeiWBGene00015510

Interactioni

Protein-protein interaction databases

BioGridi42689, 1 interactor
DIPiDIP-25109N
IntActiQ17688, 1 interactor
STRINGi6239.C06A6.5

Structurei

3D structure databases

ProteinModelPortaliQ17688
SMRiQ17688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 136ThioredoxinPROSITE-ProRule annotationAdd BLAST115

Domaini

The thioredoxin domain lacks the 2 redox-active Cys. This strongly suggests that it lacks thioredoxin activity.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0912 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000007707
InParanoidiQ17688
KOiK17264
OMAiFAHPLKH
OrthoDBiEOG091G08L8
PhylomeDBiQ17688

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 3 hits
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLASVLLLL AACHLSVSVN GQEHKEAIEL SMANHDHVLG SAQVVFVAFC
60 70 80 90 100
ADWCPFSRRL KPIFEESARV FHQENPQASA VWAIVDSQRQ ADIGDKYFVN
110 120 130 140 150
KYPTMKVFVN GELITKEYRS TRSVEALTNF VKFQLSTAIN EFSSQDQLNQ
160 170 180 190 200
EMDKSKRNVV AWLKKDGPEF ANLKKVASIL REDCSFWVPT DHFGTQTNDN
210 220 230 240 250
KLSFFDPDSN EEAKFTGNFN DYDFVKQWVT DKCIPLVREV TFENVEELTE
260 270 280 290 300
EGMPFLIYFR DPDNKTTDKV FGEAVARELY DQRSAINPLL ADGHKFAHPL
310 320 330 340 350
KHLGKTKEDL PVLAIDSFQH MYLFPDMTQM NIPGKLREFV MDLHSGKLHK
360 370 380 390 400
DFHENLDQRM IELAKAKAAR GITDDHEAQA PSTRPIDTTP PPSVFKELKP
410
SDKRYSILQK SEL
Length:413
Mass (Da):47,197
Last modified:October 1, 2001 - v2
Checksum:iF8DC1FCE63D65DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080377 Genomic DNA Translation: CCD63307.1
PIRiT29269
RefSeqiNP_501303.1, NM_068902.4
UniGeneiCel.13589

Genome annotation databases

EnsemblMetazoaiC06A6.5; C06A6.5; WBGene00015510
GeneIDi177572
KEGGicel:CELE_C06A6.5
UCSCiC06A6.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTXNDL_CAEEL
AccessioniPrimary (citable) accession number: Q17688
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health