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Protein

Thioredoxin domain-containing protein C06A6.5

Gene

C06A6.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein C06A6.5
Gene namesi
ORF Names:C06A6.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC06A6.5; CE27661; WBGene00015510.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025058722 – 413Thioredoxin domain-containing protein C06A6.5Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...)2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ17688.
PaxDbiQ17688.
PeptideAtlasiQ17688.
PRIDEiQ17688.

Expressioni

Gene expression databases

BgeeiWBGene00015510.

Interactioni

Protein-protein interaction databases

BioGridi42689. 1 interactor.
DIPiDIP-25109N.
MINTiMINT-1064553.
STRINGi6239.C06A6.5.

Structurei

3D structure databases

ProteinModelPortaliQ17688.
SMRiQ17688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 136ThioredoxinPROSITE-ProRule annotationAdd BLAST115

Domaini

The thioredoxin domain lacks the 2 redox-active Cys. This strongly suggests that it lacks thioredoxin activity.

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0912. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000007707.
InParanoidiQ17688.
KOiK17264.
OMAiHENLDQR.
OrthoDBiEOG091G08L8.
PhylomeDBiQ17688.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLASVLLLL AACHLSVSVN GQEHKEAIEL SMANHDHVLG SAQVVFVAFC
60 70 80 90 100
ADWCPFSRRL KPIFEESARV FHQENPQASA VWAIVDSQRQ ADIGDKYFVN
110 120 130 140 150
KYPTMKVFVN GELITKEYRS TRSVEALTNF VKFQLSTAIN EFSSQDQLNQ
160 170 180 190 200
EMDKSKRNVV AWLKKDGPEF ANLKKVASIL REDCSFWVPT DHFGTQTNDN
210 220 230 240 250
KLSFFDPDSN EEAKFTGNFN DYDFVKQWVT DKCIPLVREV TFENVEELTE
260 270 280 290 300
EGMPFLIYFR DPDNKTTDKV FGEAVARELY DQRSAINPLL ADGHKFAHPL
310 320 330 340 350
KHLGKTKEDL PVLAIDSFQH MYLFPDMTQM NIPGKLREFV MDLHSGKLHK
360 370 380 390 400
DFHENLDQRM IELAKAKAAR GITDDHEAQA PSTRPIDTTP PPSVFKELKP
410
SDKRYSILQK SEL
Length:413
Mass (Da):47,197
Last modified:October 1, 2001 - v2
Checksum:iF8DC1FCE63D65DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080377 Genomic DNA. Translation: CCD63307.1.
PIRiT29269.
RefSeqiNP_501303.1. NM_068902.4.
UniGeneiCel.13589.

Genome annotation databases

EnsemblMetazoaiC06A6.5; C06A6.5; WBGene00015510.
GeneIDi177572.
KEGGicel:CELE_C06A6.5.
UCSCiC06A6.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080377 Genomic DNA. Translation: CCD63307.1.
PIRiT29269.
RefSeqiNP_501303.1. NM_068902.4.
UniGeneiCel.13589.

3D structure databases

ProteinModelPortaliQ17688.
SMRiQ17688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42689. 1 interactor.
DIPiDIP-25109N.
MINTiMINT-1064553.
STRINGi6239.C06A6.5.

Proteomic databases

EPDiQ17688.
PaxDbiQ17688.
PeptideAtlasiQ17688.
PRIDEiQ17688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC06A6.5; C06A6.5; WBGene00015510.
GeneIDi177572.
KEGGicel:CELE_C06A6.5.
UCSCiC06A6.5. c. elegans.

Organism-specific databases

CTDi177572.
WormBaseiC06A6.5; CE27661; WBGene00015510.

Phylogenomic databases

eggNOGiKOG0912. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000007707.
InParanoidiQ17688.
KOiK17264.
OMAiHENLDQR.
OrthoDBiEOG091G08L8.
PhylomeDBiQ17688.

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ17688.

Gene expression databases

BgeeiWBGene00015510.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXNDL_CAEEL
AccessioniPrimary (citable) accession number: Q17688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.