Kinetochore protein ndc-80 - Caenorhabditis elegans

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Reviewed, UniProtKB/Swiss-Prot Q17635 (NDC80_CAEEL)

Last modified February 9, 2010. Version 66. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Kinetochore protein ndc-80
      Short name=CeNDC-80
Alternative name(s):
    Hec1 homolog

Gene names

Name:	ndc-80
ORF Names:	W01B6.9

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Ref.2
Subunit structure	Component of the NDC80 complex, which is composed of at least ndc-80 and him-10. The NDC80 complex interacts with knl-1.
Subcellular location	Nucleus. Kinetochore. Note: Localizes to kinetochores. Ref.2
Sequence similarities	Belongs to the NDC80/HEC1 family.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Meiosis Mitosis
Cellular component	Kinetochore Nucleus
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytokinesis Inferred from mutant phenotype. Source: WormBase embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase inductive cell migration Inferred from mutant phenotype. Source: WormBase meiosis Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase
Cellular component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein complex binding Ref.2 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q17728	1	EBI-314429,EBI-314415
	Q9GRY9	1	EBI-314429,EBI-320508
him-10	Q21952	1	EBI-314429,EBI-326288
IPL1	P38991	1	EBI-314429,EBI-9319	From a different organism.
rpl-9	Q95Y90	1	EBI-314429,EBI-312900

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 590

590

Kinetochore protein ndc-80

PRO_0000249557

Regions

Coiled coil

269 – 342

Potential

Coiled coil

450 – 525

Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q17635-1 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 77548C2EE701E8CD
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FASTA

590

68,913

        10         20         30         40         50         60 
MFGDRRKTGG LNLNGRASIA ITPTKRFTDY TGSTSVRKTD ARPSLSQPRV SLFNTKNSSV 

        70         80         90        100        110        120 
APRDVKSLVS LNGSKIYNFL VEYESSDAPS EQLIMKPRGK NDFIACFELI YQHLSKDYEF 

       130        140        150        160        170        180 
PRHERIEEEV SQIFKGLGYP YPLKNSYYQP MGSSHGYPHL LDALSWLIDI IRINSAVSED 

       190        200        210        220        230        240 
TQNILFGDFM EQGKAQEKTL NYAWMTSTFR DYTNDRKAAE NPSSSYWDDT KHRLRKYFEQ 

       250        260        270        280        290        300 
SNEFEDMTKT AASALEMLNY ECDEIEADKG NEASLKEEIS RIRDDIRKAK DYLEQNLHVK 

       310        320        330        340        350        360 
QHMEKELAMV KSEQEEKISE NEKVQKMVDD LKNKIELQKQ IHGLTGKEVR QMNLDNNKDK 

       370        380        390        400        410        420 
EVVLEIQSEL DRLSKETWKL KDEDFFKEQK SKFIHLAEQI MKILSGLNIQ MNLEPLRAPT 

       430        440        450        460        470        480 
NERDLKDYWE TLNKIWVPEI SRQLHQRKLE LETEQSRFSN KAVTAEERIQ IQSETLCEAK 

       490        500        510        520        530        540 
KNEAREERIR RNERDSWKDA RKHIEQRYEQ LLNEKEVLLK QMKLDGSLEK EIEDETARMS 

       550        560        570        580        590 
ATGEEHIQKR SQLEAGIRQI LDLMVVEIAE IENKKIGFHV QCAGIEKAVL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans." Desai A., Rybina S., Mueller-Reichert T., Shevchenko A., Shevchenko A., Hyman A., Oegema K. Genes Dev. 17:2421-2435(2003) [PubMed: 14522947] [Abstract] Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH HIM-10 AND KNL-1, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68301, Z70718 Genomic DNA. Translation: CAA92629.1. Z70718, Z68301 Genomic DNA. Translation: CAA94680.1.
PIR	T18927.
RefSeq	NP_501830.1.
UniGene	Cel.12240
3D structure databases
SMR	Q17635. Positions 62-174.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25850N.
IntAct	Q17635. 19 interactions.
STRING	Q17635.
Genome annotation databases
Ensembl	W01B6.9.1; W01B6.9.1; W01B6.9; Caenorhabditis elegans. [Genome view] W01B6.9.2; W01B6.9.2; W01B6.9; Caenorhabditis elegans. [Genome view]
GeneID	177873.
KEGG	cel:W01B6.9.
UCSC	W01B6.9.1. c. elegans.
Organism-specific databases
CTD	177873.
WormBase	WBGene00003576. ndc-80.
WormPep	W01B6.9. CE06537. [WorfDB]
Phylogenomic databases
eggNOG	meNOG07851.
HOGENOM	HBG385585.
InParanoid	Q17635.
OMA	APRDVKS.
PhylomeDB	Q17635.
Gene expression databases
ArrayExpress	Q17635.
Family and domain databases
InterPro	IPR005550. Kinetochore_Ndc80. [Graphical view]
PANTHER	PTHR10643. Ndc80_HEC. 1 hit.
Pfam	PF03801. Ndc80_HEC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	898748.

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Entry information

Entry name

NDC80_CAEEL

Accession

Primary (citable) accession number: Q17635
Secondary accession number(s): Q23107

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	November 1, 1998
Last modified:	February 9, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents