Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q174S1

- Q174S1_AEDAE

UniProt

Q174S1 - Q174S1_AEDAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

AAEL006783

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:AAEL006783Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL006783-PA.

Structurei

3D structure databases

ProteinModelPortaliQ174S1.
SMRiQ174S1. Positions 8-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000044279.
InParanoidiQ174S1.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiQ174S1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q174S1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPNYKELK LQSPAGAEPF LYNWPFSIGG GNDNGGMELI ENVRWVCEDM
60 70 80 90 100
PEIKSAIEEI NLNDIDTGDY DAMKNLCDRF NKAIDSVTAL EKGTSLSNQR
110 120 130 140 150
FTYPSRGLLR HIVQQVYNQA VVEPEKLNQY EPFSPEVYGE TSFDLICQMI
160 170 180 190 200
DEIKITADDV FVDLGSGVGQ VVLQMAASTP VKICYGIEKA DVPSRYAEGM
210 220 230 240 250
NATFKMWMRW FGKKYGDYEL IKGDFLADEH REKIMSATIV FVNNFAFGPN
260 270 280 290 300
VDHQLKERFA DLRDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP
310 320 330 340 350
LKGSVSWTGK PVSYYLHIID RTKLERYFQR LKTKGNENDN QASGSTNTRA
360 370 380 390 400
SRSRKDKCEK AVTNDESTSD SDAEPAGPPN RKQPWSDWCS GKEKESSQSE
410 420 430 440 450
EENNNSPVLR NGRIPVATKK RKKITRPKTV KKDPVAQAAQ QAAKEAQAAV
460 470 480 490 500
TKRRGRVKKG RQRRALKING LDLLHSETLL STSDQAIGKR LPPAPGCVDQ
510 520 530 540 550
LLTSLAGDMQ HTELDIPEAP SETPYGLQIL LDLYKTQFMK AIESMRKSSY
560 570 580 590 600
KDNVQQQIER EKERNQRLLN RAGQLEKQIK VLIDDSVALL KARMNELGIS
610 620 630 640 650
TTSQNDLLCK AKEIVGRHKE LQVMAAKLQN QVTSIEQEQK RLVMQHVQRI
660 670 680 690 700
ADKYIKTEDV EMTPKTSHEL VLKEIANTLS QRKKLYAQVS SMENELNVIE
710 720 730 740 750
KLAEERKAAA VLQTTIVTHQ RGEQPLQQPS GSSRSQRKSR ENRTRSQEWP
760 770 780 790 800
EIPDIGKIEE NNPEILAQKI LETGRQIEAG KLLANSASKH QKERESKNHH
810 820 830 840 850
LQQQYQQSQQ THQLPHHTHP ADAALMPAPA TLSKSHHRGG STTNIKSESR
860 870 880 890 900
SKLQDSHKVV NFEDRLKSII TSVLQAPPKS IGSGGGLQQQ QQPPPHQGSS
910 920 930 940 950
QHHMREVSQP MLLGHGEHAS PTKSSSSYGK TVYLTSGPPP PPSSMHNSLH
960 970 980 990 1000
DMGPRNSGNQ HHLPHPSSGG QTSQPPSQFS SLMNPVTTAH HLNATTTITS
1010 1020 1030 1040 1050
SPISPYKGHG SSQRANSTHQ QILQQQERDR ELRQTQMAMH YGSHSGQPHP
1060 1070 1080 1090 1100
NVVDPHLLHR SALEGKMEFK APEQFRYDHR NPIEPPMGGQ SHSRSSSATS
1110 1120 1130 1140 1150
LEGDYSSAGS NLRYVNVPTN PQQQPQQVPL QQQQLSGGNN SRPGSSSSQP
1160 1170 1180 1190 1200
DYTQVSPAKM ALRRHLSQEK LTHPMPPSSN TVKTIGDLVN GEIERTLEIS
1210 1220 1230 1240 1250
NQSIINAAVN MSTAGPSGHT VINTNVQRPE RVSIRVLEEA GLNGSVQASS
1260 1270 1280 1290 1300
YSPVSRPSSR EMTKSPVHLH GQSNLATLAQ VATYNHKKAS SSSSSSSSSA
1310 1320 1330 1340 1350
AVISPRGGPV QQPVDNRGHS TSTQQYPQTA PHASVVYQPS RGGEKPSYSS
1360 1370 1380 1390 1400
SSDRHGAEPT YMALPRADIK PHLDSYFIDE HKRQQQQQQQ QQQQQHQLHR
1410 1420 1430 1440 1450
QDSAAVGSHL PPTSHHQTGS SGMRVTMGDM YHRGHAVSAM EQSHPRREPM
1460 1470 1480 1490 1500
ASQAIDDRMN GSPPLEGLAA SLRARVIAQL NSKDEDVERH RRPDLGAPMH
1510 1520 1530 1540 1550
TGPVNSNNTI QLVQAPHVKT EKYSAGIKRT SPIIENPPRP PKMLYTDCSD
1560 1570 1580 1590 1600
AMVNSDLLHV GRSGSGSSRG MGPLMSPEIN SLSAVDDRQH LMRHGRNDVD
1610 1620 1630 1640 1650
GSSSSSSNVA GLHQQQPTSS SSVTVINLPY GSGGMSSANT GCSNPPSQRN
1660 1670 1680 1690 1700
YNHHQQQRPM QPQHQQQQQQ QSHQQYRVQS RNDGQIPPAQ RHHHYAPNKY

PPNSYSK
Length:1,707
Mass (Da):189,355
Last modified:July 25, 2006 - v1
Checksum:i49BD9987B3EDC97E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477406 Genomic DNA. Translation: EAT41580.1.
RefSeqiXP_001652229.1. XM_001652179.1.
UniGeneiAae.10930.

Genome annotation databases

GeneIDi5579940.
KEGGiaag:AaeL_AAEL006783.
VectorBaseiAAEL006783. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477406 Genomic DNA. Translation: EAT41580.1 .
RefSeqi XP_001652229.1. XM_001652179.1.
UniGenei Aae.10930.

3D structure databases

ProteinModelPortali Q174S1.
SMRi Q174S1. Positions 8-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL006783-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5579940.
KEGGi aag:AaeL_AAEL006783.
VectorBasei AAEL006783. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG294902.
HOGENOMi HOG000044279.
InParanoidi Q174S1.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi Q174S1.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12Imported.

Entry informationi

Entry nameiQ174S1_AEDAE
AccessioniPrimary (citable) accession number: Q174S1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3