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Q174S1 (Q174S1_AEDAE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:AAEL006783 EMBL EAT41580.1
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome] EMBL EAT41580.1
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length1707 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Sequences

Sequence LengthMass (Da)Tools
Q174S1 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 49BD9987B3EDC97E

FASTA1,707189,355
        10         20         30         40         50         60 
MATPNYKELK LQSPAGAEPF LYNWPFSIGG GNDNGGMELI ENVRWVCEDM PEIKSAIEEI 

        70         80         90        100        110        120 
NLNDIDTGDY DAMKNLCDRF NKAIDSVTAL EKGTSLSNQR FTYPSRGLLR HIVQQVYNQA 

       130        140        150        160        170        180 
VVEPEKLNQY EPFSPEVYGE TSFDLICQMI DEIKITADDV FVDLGSGVGQ VVLQMAASTP 

       190        200        210        220        230        240 
VKICYGIEKA DVPSRYAEGM NATFKMWMRW FGKKYGDYEL IKGDFLADEH REKIMSATIV 

       250        260        270        280        290        300 
FVNNFAFGPN VDHQLKERFA DLRDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP 

       310        320        330        340        350        360 
LKGSVSWTGK PVSYYLHIID RTKLERYFQR LKTKGNENDN QASGSTNTRA SRSRKDKCEK 

       370        380        390        400        410        420 
AVTNDESTSD SDAEPAGPPN RKQPWSDWCS GKEKESSQSE EENNNSPVLR NGRIPVATKK 

       430        440        450        460        470        480 
RKKITRPKTV KKDPVAQAAQ QAAKEAQAAV TKRRGRVKKG RQRRALKING LDLLHSETLL 

       490        500        510        520        530        540 
STSDQAIGKR LPPAPGCVDQ LLTSLAGDMQ HTELDIPEAP SETPYGLQIL LDLYKTQFMK 

       550        560        570        580        590        600 
AIESMRKSSY KDNVQQQIER EKERNQRLLN RAGQLEKQIK VLIDDSVALL KARMNELGIS 

       610        620        630        640        650        660 
TTSQNDLLCK AKEIVGRHKE LQVMAAKLQN QVTSIEQEQK RLVMQHVQRI ADKYIKTEDV 

       670        680        690        700        710        720 
EMTPKTSHEL VLKEIANTLS QRKKLYAQVS SMENELNVIE KLAEERKAAA VLQTTIVTHQ 

       730        740        750        760        770        780 
RGEQPLQQPS GSSRSQRKSR ENRTRSQEWP EIPDIGKIEE NNPEILAQKI LETGRQIEAG 

       790        800        810        820        830        840 
KLLANSASKH QKERESKNHH LQQQYQQSQQ THQLPHHTHP ADAALMPAPA TLSKSHHRGG 

       850        860        870        880        890        900 
STTNIKSESR SKLQDSHKVV NFEDRLKSII TSVLQAPPKS IGSGGGLQQQ QQPPPHQGSS 

       910        920        930        940        950        960 
QHHMREVSQP MLLGHGEHAS PTKSSSSYGK TVYLTSGPPP PPSSMHNSLH DMGPRNSGNQ 

       970        980        990       1000       1010       1020 
HHLPHPSSGG QTSQPPSQFS SLMNPVTTAH HLNATTTITS SPISPYKGHG SSQRANSTHQ 

      1030       1040       1050       1060       1070       1080 
QILQQQERDR ELRQTQMAMH YGSHSGQPHP NVVDPHLLHR SALEGKMEFK APEQFRYDHR 

      1090       1100       1110       1120       1130       1140 
NPIEPPMGGQ SHSRSSSATS LEGDYSSAGS NLRYVNVPTN PQQQPQQVPL QQQQLSGGNN 

      1150       1160       1170       1180       1190       1200 
SRPGSSSSQP DYTQVSPAKM ALRRHLSQEK LTHPMPPSSN TVKTIGDLVN GEIERTLEIS 

      1210       1220       1230       1240       1250       1260 
NQSIINAAVN MSTAGPSGHT VINTNVQRPE RVSIRVLEEA GLNGSVQASS YSPVSRPSSR 

      1270       1280       1290       1300       1310       1320 
EMTKSPVHLH GQSNLATLAQ VATYNHKKAS SSSSSSSSSA AVISPRGGPV QQPVDNRGHS 

      1330       1340       1350       1360       1370       1380 
TSTQQYPQTA PHASVVYQPS RGGEKPSYSS SSDRHGAEPT YMALPRADIK PHLDSYFIDE 

      1390       1400       1410       1420       1430       1440 
HKRQQQQQQQ QQQQQHQLHR QDSAAVGSHL PPTSHHQTGS SGMRVTMGDM YHRGHAVSAM 

      1450       1460       1470       1480       1490       1500 
EQSHPRREPM ASQAIDDRMN GSPPLEGLAA SLRARVIAQL NSKDEDVERH RRPDLGAPMH 

      1510       1520       1530       1540       1550       1560 
TGPVNSNNTI QLVQAPHVKT EKYSAGIKRT SPIIENPPRP PKMLYTDCSD AMVNSDLLHV 

      1570       1580       1590       1600       1610       1620 
GRSGSGSSRG MGPLMSPEIN SLSAVDDRQH LMRHGRNDVD GSSSSSSNVA GLHQQQPTSS 

      1630       1640       1650       1660       1670       1680 
SSVTVINLPY GSGGMSSANT GCSNPPSQRN YNHHQQQRPM QPQHQQQQQQ QSHQQYRVQS 

      1690       1700 
RNDGQIPPAQ RHHHYAPNKY PPNSYSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH477406 Genomic DNA. Translation: EAT41580.1.
RefSeqXP_001652229.1. XM_001652179.1.
UniGeneAae.10930.

3D structure databases

ProteinModelPortalQ174S1.
SMRQ174S1. Positions 8-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7159.AAEL006783-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5579940.
KEGGaag:AaeL_AAEL006783.
VectorBaseAAEL006783. Aedes aegypti.

Phylogenomic databases

eggNOGNOG294902.
HOGENOMHOG000044279.
KOK11427.
OMAQVSPAKM.
OrthoDBEOG7W6WJV.
PhylomeDBQ174S1.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ174S1_AEDAE
AccessionPrimary (citable) accession number: Q174S1
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)