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Q174S1

- Q174S1_AEDAE

UniProt

Q174S1 - Q174S1_AEDAE

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
AAEL006783
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:AAEL006783Imported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL006783-PA.

Structurei

3D structure databases

ProteinModelPortaliQ174S1.
SMRiQ174S1. Positions 8-332.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000044279.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiQ174S1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q174S1-1 [UniParc]FASTAAdd to Basket

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MATPNYKELK LQSPAGAEPF LYNWPFSIGG GNDNGGMELI ENVRWVCEDM     50
PEIKSAIEEI NLNDIDTGDY DAMKNLCDRF NKAIDSVTAL EKGTSLSNQR 100
FTYPSRGLLR HIVQQVYNQA VVEPEKLNQY EPFSPEVYGE TSFDLICQMI 150
DEIKITADDV FVDLGSGVGQ VVLQMAASTP VKICYGIEKA DVPSRYAEGM 200
NATFKMWMRW FGKKYGDYEL IKGDFLADEH REKIMSATIV FVNNFAFGPN 250
VDHQLKERFA DLRDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP 300
LKGSVSWTGK PVSYYLHIID RTKLERYFQR LKTKGNENDN QASGSTNTRA 350
SRSRKDKCEK AVTNDESTSD SDAEPAGPPN RKQPWSDWCS GKEKESSQSE 400
EENNNSPVLR NGRIPVATKK RKKITRPKTV KKDPVAQAAQ QAAKEAQAAV 450
TKRRGRVKKG RQRRALKING LDLLHSETLL STSDQAIGKR LPPAPGCVDQ 500
LLTSLAGDMQ HTELDIPEAP SETPYGLQIL LDLYKTQFMK AIESMRKSSY 550
KDNVQQQIER EKERNQRLLN RAGQLEKQIK VLIDDSVALL KARMNELGIS 600
TTSQNDLLCK AKEIVGRHKE LQVMAAKLQN QVTSIEQEQK RLVMQHVQRI 650
ADKYIKTEDV EMTPKTSHEL VLKEIANTLS QRKKLYAQVS SMENELNVIE 700
KLAEERKAAA VLQTTIVTHQ RGEQPLQQPS GSSRSQRKSR ENRTRSQEWP 750
EIPDIGKIEE NNPEILAQKI LETGRQIEAG KLLANSASKH QKERESKNHH 800
LQQQYQQSQQ THQLPHHTHP ADAALMPAPA TLSKSHHRGG STTNIKSESR 850
SKLQDSHKVV NFEDRLKSII TSVLQAPPKS IGSGGGLQQQ QQPPPHQGSS 900
QHHMREVSQP MLLGHGEHAS PTKSSSSYGK TVYLTSGPPP PPSSMHNSLH 950
DMGPRNSGNQ HHLPHPSSGG QTSQPPSQFS SLMNPVTTAH HLNATTTITS 1000
SPISPYKGHG SSQRANSTHQ QILQQQERDR ELRQTQMAMH YGSHSGQPHP 1050
NVVDPHLLHR SALEGKMEFK APEQFRYDHR NPIEPPMGGQ SHSRSSSATS 1100
LEGDYSSAGS NLRYVNVPTN PQQQPQQVPL QQQQLSGGNN SRPGSSSSQP 1150
DYTQVSPAKM ALRRHLSQEK LTHPMPPSSN TVKTIGDLVN GEIERTLEIS 1200
NQSIINAAVN MSTAGPSGHT VINTNVQRPE RVSIRVLEEA GLNGSVQASS 1250
YSPVSRPSSR EMTKSPVHLH GQSNLATLAQ VATYNHKKAS SSSSSSSSSA 1300
AVISPRGGPV QQPVDNRGHS TSTQQYPQTA PHASVVYQPS RGGEKPSYSS 1350
SSDRHGAEPT YMALPRADIK PHLDSYFIDE HKRQQQQQQQ QQQQQHQLHR 1400
QDSAAVGSHL PPTSHHQTGS SGMRVTMGDM YHRGHAVSAM EQSHPRREPM 1450
ASQAIDDRMN GSPPLEGLAA SLRARVIAQL NSKDEDVERH RRPDLGAPMH 1500
TGPVNSNNTI QLVQAPHVKT EKYSAGIKRT SPIIENPPRP PKMLYTDCSD 1550
AMVNSDLLHV GRSGSGSSRG MGPLMSPEIN SLSAVDDRQH LMRHGRNDVD 1600
GSSSSSSNVA GLHQQQPTSS SSVTVINLPY GSGGMSSANT GCSNPPSQRN 1650
YNHHQQQRPM QPQHQQQQQQ QSHQQYRVQS RNDGQIPPAQ RHHHYAPNKY 1700
PPNSYSK 1707
Length:1,707
Mass (Da):189,355
Last modified:July 25, 2006 - v1
Checksum:i49BD9987B3EDC97E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477406 Genomic DNA. Translation: EAT41580.1.
RefSeqiXP_001652229.1. XM_001652179.1.
UniGeneiAae.10930.

Genome annotation databases

GeneIDi5579940.
KEGGiaag:AaeL_AAEL006783.
VectorBaseiAAEL006783. Aedes aegypti.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH477406 Genomic DNA. Translation: EAT41580.1 .
RefSeqi XP_001652229.1. XM_001652179.1.
UniGenei Aae.10930.

3D structure databases

ProteinModelPortali Q174S1.
SMRi Q174S1. Positions 8-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7159.AAEL006783-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5579940.
KEGGi aag:AaeL_AAEL006783.
VectorBasei AAEL006783. Aedes aegypti.

Phylogenomic databases

eggNOGi NOG294902.
HOGENOMi HOG000044279.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi Q174S1.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.

Entry informationi

Entry nameiQ174S1_AEDAE
AccessioniPrimary (citable) accession number: Q174S1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi