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Q17449

- FAAH1_CAEEL

UniProt

Q17449 - FAAH1_CAEEL

Protein

Fatty acid amide hydrolase 1

Gene

faah-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high.1 Publication

    Catalytic activityi

    Anandamide + H2O = arachidonic acid + ethanolamine.
    Oleamide + H2O = oleic acid + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391Charge relay systemBy similarity
    Active sitei214 – 2141Charge relay systemBy similarity
    Binding sitei214 – 2141SubstrateBy similarity
    Active sitei238 – 2381Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
    2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty acid amide hydrolase 1 (EC:3.5.1.99)
    Gene namesi
    Name:faah-1
    ORF Names:B0218.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiB0218.1a; CE06684; WBGene00015047; faah-1.
    B0218.1b; CE33351; WBGene00015047; faah-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 572558Fatty acid amide hydrolase 1PRO_0000421279Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ17449.
    PRIDEiQ17449.

    Expressioni

    Tissue specificityi

    Expressed in the pharynx, some pharyngeal neurons, and the posterior intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ17449.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0218.1a.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17449.
    SMRiQ17449. Positions 34-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 2384Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 6332Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the amidase family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiCOG0154.
    GeneTreeiENSGT00550000074673.
    HOGENOMiHOG000016500.
    InParanoidiQ17449.
    KOiK15528.
    OMAiANDGPMA.
    OrthoDBiEOG72JWG0.
    PhylomeDBiQ17449.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR015830. Amidase_fun_type.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001221. Amidase_fungi. 1 hit.
    SUPFAMiSSF75304. SSF75304. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q17449-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIFYLVLLVL GAIAFYVHFS NNRKKLIERL EIVAQRRRDD LSKNVEQARK    50
    AADKLDTQRR DWIGSLDFEQ LRDELQRGHV TCVEAIRAYF HKAILAHEKT 100
    NAVTCFILDA ERQAEELDEQ AKLPYYVKPP LFGVPLSLKE CLKVKGYDTT 150
    RGFVQDAYHP ATEDSIQVEH YKKLGLIPFC QTNVPQSLLS YNCSNPLFGT 200
    TTNPYDSTRT CGGSSGGEGA LIGAGGSLIG IGTDVGGSVR IPCHFTGTAG 250
    IKPSKMRFAH RGGGASVPGK PLIDANDGPM AKDVKTNVEF LRNVWGDIDF 300
    QSDRDPYCPP VHWNESVYSS EKKLRVGYYI DDGWFTPTPA LQRAVLESKK 350
    HLEAAGHTVI PFYPPRLPSV MQLYFRAVCL DGGQYVLNKL LKDIIEPTIR 400
    FQVTLWMVPV WIQRILSYPV SLVFPRMGML MQSLTRDTFE LREAYADIEA 450
    YREEFVGLMM KDNLDVILCP ASIMPAPQHD IPSKVVSGVS YTCLYNLLDF 500
    GAGVVPVTAV SKSDEEKLIN EYPETDKWYQ ITKKATLGAV GMPIGVQVAA 550
    PPYREEAVLR TMREIEIAVT GK 572
    Length:572
    Mass (Da):64,001
    Last modified:November 1, 1996 - v1
    Checksum:i4CE781426865D6E9
    GO
    Isoform b (identifier: Q17449-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         176-240: Missing.

    Show »
    Length:507
    Mass (Da):57,581
    Checksum:iAC99192C957DD3D6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei176 – 24065Missing in isoform b. CuratedVSP_045382Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080124 Genomic DNA. Translation: CCD61383.1.
    FO080124 Genomic DNA. Translation: CCD61384.1.
    PIRiT29753.
    RefSeqiNP_501368.1. NM_068967.5. [Q17449-1]
    NP_872095.1. NM_182295.3. [Q17449-2]
    UniGeneiCel.17636.

    Genome annotation databases

    EnsemblMetazoaiB0218.1a.1; B0218.1a.1; WBGene00015047. [Q17449-1]
    B0218.1a.2; B0218.1a.2; WBGene00015047. [Q17449-1]
    B0218.1a.3; B0218.1a.3; WBGene00015047. [Q17449-1]
    B0218.1a.4; B0218.1a.4; WBGene00015047. [Q17449-1]
    GeneIDi177613.
    KEGGicel:CELE_B0218.1.
    UCSCiB0218.1a.1. c. elegans. [Q17449-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080124 Genomic DNA. Translation: CCD61383.1 .
    FO080124 Genomic DNA. Translation: CCD61384.1 .
    PIRi T29753.
    RefSeqi NP_501368.1. NM_068967.5. [Q17449-1 ]
    NP_872095.1. NM_182295.3. [Q17449-2 ]
    UniGenei Cel.17636.

    3D structure databases

    ProteinModelPortali Q17449.
    SMRi Q17449. Positions 34-570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0218.1a.3.

    Proteomic databases

    PaxDbi Q17449.
    PRIDEi Q17449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0218.1a.1 ; B0218.1a.1 ; WBGene00015047 . [Q17449-1 ]
    B0218.1a.2 ; B0218.1a.2 ; WBGene00015047 . [Q17449-1 ]
    B0218.1a.3 ; B0218.1a.3 ; WBGene00015047 . [Q17449-1 ]
    B0218.1a.4 ; B0218.1a.4 ; WBGene00015047 . [Q17449-1 ]
    GeneIDi 177613.
    KEGGi cel:CELE_B0218.1.
    UCSCi B0218.1a.1. c. elegans. [Q17449-1 ]

    Organism-specific databases

    CTDi 177613.
    WormBasei B0218.1a ; CE06684 ; WBGene00015047 ; faah-1.
    B0218.1b ; CE33351 ; WBGene00015047 ; faah-1.

    Phylogenomic databases

    eggNOGi COG0154.
    GeneTreei ENSGT00550000074673.
    HOGENOMi HOG000016500.
    InParanoidi Q17449.
    KOi K15528.
    OMAi ANDGPMA.
    OrthoDBi EOG72JWG0.
    PhylomeDBi Q17449.

    Miscellaneous databases

    NextBioi 897594.

    Gene expression databases

    ArrayExpressi Q17449.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR015830. Amidase_fun_type.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001221. Amidase_fungi. 1 hit.
    SUPFAMi SSF75304. SSF75304. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans."
      Lucanic M., Held J.M., Vantipalli M.C., Klang I.M., Graham J.B., Gibson B.W., Lithgow G.J., Gill M.S.
      Nature 473:226-229(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFAAH1_CAEEL
    AccessioniPrimary (citable) accession number: Q17449
    Secondary accession number(s): H2KY70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3