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Q17449 (FAAH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acid amide hydrolase 1

EC=3.5.1.99
Gene names
Name:faah-1
ORF Names:B0218.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Ref.2

Catalytic activity

Anandamide + H2O = arachidonic acid + ethanolamine.

Oleamide + H2O = oleic acid + NH3.

Tissue specificity

Expressed in the pharynx, some pharyngeal neurons, and the posterior intestine. Ref.2

Sequence similarities

Belongs to the amidase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q17449-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: Q17449-2)

The sequence of this isoform differs from the canonical sequence as follows:
     176-240: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1414 Potential
Chain15 – 572558Fatty acid amide hydrolase 1
PRO_0000421279

Regions

Region235 – 2384Substrate binding By similarity
Coiled coil32 – 6332 Potential

Sites

Active site1391Charge relay system By similarity
Active site2141Charge relay system By similarity
Active site2381Acyl-ester intermediate By similarity
Binding site2141Substrate By similarity

Natural variations

Alternative sequence176 – 24065Missing in isoform b.
VSP_045382

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4CE781426865D6E9

FASTA57264,001
        10         20         30         40         50         60 
MIFYLVLLVL GAIAFYVHFS NNRKKLIERL EIVAQRRRDD LSKNVEQARK AADKLDTQRR 

        70         80         90        100        110        120 
DWIGSLDFEQ LRDELQRGHV TCVEAIRAYF HKAILAHEKT NAVTCFILDA ERQAEELDEQ 

       130        140        150        160        170        180 
AKLPYYVKPP LFGVPLSLKE CLKVKGYDTT RGFVQDAYHP ATEDSIQVEH YKKLGLIPFC 

       190        200        210        220        230        240 
QTNVPQSLLS YNCSNPLFGT TTNPYDSTRT CGGSSGGEGA LIGAGGSLIG IGTDVGGSVR 

       250        260        270        280        290        300 
IPCHFTGTAG IKPSKMRFAH RGGGASVPGK PLIDANDGPM AKDVKTNVEF LRNVWGDIDF 

       310        320        330        340        350        360 
QSDRDPYCPP VHWNESVYSS EKKLRVGYYI DDGWFTPTPA LQRAVLESKK HLEAAGHTVI 

       370        380        390        400        410        420 
PFYPPRLPSV MQLYFRAVCL DGGQYVLNKL LKDIIEPTIR FQVTLWMVPV WIQRILSYPV 

       430        440        450        460        470        480 
SLVFPRMGML MQSLTRDTFE LREAYADIEA YREEFVGLMM KDNLDVILCP ASIMPAPQHD 

       490        500        510        520        530        540 
IPSKVVSGVS YTCLYNLLDF GAGVVPVTAV SKSDEEKLIN EYPETDKWYQ ITKKATLGAV 

       550        560        570 
GMPIGVQVAA PPYREEAVLR TMREIEIAVT GK 

« Hide

Isoform b [UniParc].

Checksum: AC99192C957DD3D6
Show »

FASTA50757,581

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[2]"N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans."
Lucanic M., Held J.M., Vantipalli M.C., Klang I.M., Graham J.B., Gibson B.W., Lithgow G.J., Gill M.S.
Nature 473:226-229(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080124 Genomic DNA. Translation: CCD61383.1.
FO080124 Genomic DNA. Translation: CCD61384.1.
PIRT29753.
RefSeqNP_501368.1. NM_068967.5.
NP_872095.1. NM_182295.3.
UniGeneCel.17636.

3D structure databases

ProteinModelPortalQ17449.
SMRQ17449. Positions 34-570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0218.1a.3.

Proteomic databases

PaxDbQ17449.
PRIDEQ17449.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0218.1a.1; B0218.1a.1; B0218.1. [Q17449-1]
B0218.1a.2; B0218.1a.2; B0218.1. [Q17449-1]
B0218.1a.3; B0218.1a.3; B0218.1. [Q17449-1]
B0218.1a.4; B0218.1a.4; B0218.1. [Q17449-1]
B0218.1b.1; B0218.1b.1; B0218.1. [Q17449-2]
B0218.1b.2; B0218.1b.2; B0218.1. [Q17449-2]
B0218.1b.3; B0218.1b.3; B0218.1. [Q17449-2]
B0218.1b.4; B0218.1b.4; B0218.1. [Q17449-2]
GeneID177613.
KEGGcel:CELE_B0218.1.
UCSCB0218.1a.1. c. elegans. [Q17449-1]

Organism-specific databases

CTD177613.
WormBaseB0218.1a; CE06684; WBGene00015047; faah-1.
B0218.1b; CE33351; WBGene00015047; faah-1.

Phylogenomic databases

eggNOGCOG0154.
HOGENOMHOG000016500.
InParanoidQ17449.
KOK15528.
OMAANDGPMA.
OrthoDBEOG72JWG0.
PhylomeDBQ17449.

Gene expression databases

ArrayExpressQ17449.

Family and domain databases

Gene3D3.90.1300.10. 1 hit.
InterProIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR015830. Amidase_fun.
[Graphical view]
PANTHERPTHR11895. PTHR11895. 1 hit.
PTHR11895:SF4. PTHR11895:SF4. 1 hit.
PfamPF01425. Amidase. 1 hit.
[Graphical view]
PIRSFPIRSF001221. Amidase_fungi. 1 hit.
SUPFAMSSF75304. SSF75304. 1 hit.
PROSITEPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio897594.

Entry information

Entry nameFAAH1_CAEEL
AccessionPrimary (citable) accession number: Q17449
Secondary accession number(s): H2KY70
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase