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Q17428 (PORED_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyprenol reductase

EC=1.3.1.94
Gene names
ORF Names:B0024.13
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activity

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Polyprenol reductase
PRO_0000398653

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane242 – 26221Helical; Potential
Transmembrane270 – 29021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q17428 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 1D4F125A25B3A9EC

FASTA30935,430
        10         20         30         40         50         60 
MLDRLWEVRQ ALPLYLLVST LGLAISCCFT LICPHVCRLI PALTTYGKAA DQQEDNSLVE 

        70         80         90        100        110        120 
KISVPKKWFK HFYAIGLLTL FICLHTVHSL IYNPNYLHPV VLKILATLTR SYSIPPITPS 

       130        140        150        160        170        180 
TSILALLLIS LHVARRLYET IFVSVYSDSR MNLFHYAVGI VHYIILPISI MCETQGVASK 

       190        200        210        220        230        240 
LPQLHVSIDD ISLTQWAGAV LFWICNWKQH QLAEQIANTR KGPRGLIRNY AYGICFGGWF 

       250        260        270        280        290        300 
NLVSCPHFLF EICIYLSLFL VIPDAYVYRF IIMFVCINQT FAALITHSWY HKTFPKYPKS 


RKALIPYVL 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71178 Genomic DNA. Translation: CAA94885.2.
PIRT18648.
RefSeqNP_001256209.1. NM_001269280.1.
UniGeneCel.9469.

3D structure databases

ProteinModelPortalQ17428.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0024.13b.

Proteomic databases

PaxDbQ17428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0024.13; B0024.13; WBGene00007102.
GeneID179438.
KEGGcel:CELE_B0024.13.
UCSCB0024.13a. c. elegans.

Organism-specific databases

CTD179438.
WormBaseB0024.13; CE35376; WBGene00007102.

Phylogenomic databases

eggNOGNOG330066.
GeneTreeENSGT00500000044920.
HOGENOMHOG000018885.
InParanoidQ7JLP4.
KOK12345.
OMATSAPEFN.
OrthoDBEOG72ZCFT.
PhylomeDBQ17428.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio905390.
PROQ17428.

Entry information

Entry namePORED_CAEEL
AccessionPrimary (citable) accession number: Q17428
Secondary accession number(s): Q7JLP4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase