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Q17428

- PORED_CAEEL

UniProt

Q17428 - PORED_CAEEL

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Protein

Polyprenol reductase

Gene
B0024.13
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

GO - Biological processi

  1. dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
  2. dolichol metabolic process Source: UniProtKB
  3. polyprenol catabolic process Source: UniProtKB
  4. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_104244. Androgen biosynthesis.
REACT_183451. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
Gene namesi
ORF Names:B0024.13
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiB0024.13; CE35376; WBGene00007102.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Transmembranei184 – 20421Helical; Reviewed predictionAdd
BLAST
Transmembranei242 – 26221Helical; Reviewed predictionAdd
BLAST
Transmembranei270 – 29021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Polyprenol reductasePRO_0000398653Add
BLAST

Proteomic databases

PaxDbiQ17428.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0024.13b.

Structurei

3D structure databases

ProteinModelPortaliQ17428.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330066.
GeneTreeiENSGT00500000044920.
HOGENOMiHOG000018885.
InParanoidiQ7JLP4.
KOiK12345.
OMAiTSAPEFN.
OrthoDBiEOG72ZCFT.
PhylomeDBiQ17428.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17428-1 [UniParc]FASTAAdd to Basket

« Hide

MLDRLWEVRQ ALPLYLLVST LGLAISCCFT LICPHVCRLI PALTTYGKAA    50
DQQEDNSLVE KISVPKKWFK HFYAIGLLTL FICLHTVHSL IYNPNYLHPV 100
VLKILATLTR SYSIPPITPS TSILALLLIS LHVARRLYET IFVSVYSDSR 150
MNLFHYAVGI VHYIILPISI MCETQGVASK LPQLHVSIDD ISLTQWAGAV 200
LFWICNWKQH QLAEQIANTR KGPRGLIRNY AYGICFGGWF NLVSCPHFLF 250
EICIYLSLFL VIPDAYVYRF IIMFVCINQT FAALITHSWY HKTFPKYPKS 300
RKALIPYVL 309
Length:309
Mass (Da):35,430
Last modified:July 5, 2004 - v2
Checksum:i1D4F125A25B3A9EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71178 Genomic DNA. Translation: CAA94885.2.
PIRiT18648.
RefSeqiNP_001256209.1. NM_001269280.1.
UniGeneiCel.9469.

Genome annotation databases

EnsemblMetazoaiB0024.13; B0024.13; WBGene00007102.
GeneIDi179438.
KEGGicel:CELE_B0024.13.
UCSCiB0024.13a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71178 Genomic DNA. Translation: CAA94885.2 .
PIRi T18648.
RefSeqi NP_001256209.1. NM_001269280.1.
UniGenei Cel.9469.

3D structure databases

ProteinModelPortali Q17428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.B0024.13b.

Proteomic databases

PaxDbi Q17428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0024.13 ; B0024.13 ; WBGene00007102 .
GeneIDi 179438.
KEGGi cel:CELE_B0024.13.
UCSCi B0024.13a. c. elegans.

Organism-specific databases

CTDi 179438.
WormBasei B0024.13 ; CE35376 ; WBGene00007102 .

Phylogenomic databases

eggNOGi NOG330066.
GeneTreei ENSGT00500000044920.
HOGENOMi HOG000018885.
InParanoidi Q7JLP4.
KOi K12345.
OMAi TSAPEFN.
OrthoDBi EOG72ZCFT.
PhylomeDBi Q17428.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_104244. Androgen biosynthesis.
REACT_183451. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

NextBioi 905390.
PROi Q17428.

Family and domain databases

InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPORED_CAEEL
AccessioniPrimary (citable) accession number: Q17428
Secondary accession number(s): Q7JLP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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