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Q17428

- PORED_CAEEL

UniProt

Q17428 - PORED_CAEEL

Protein

Polyprenol reductase

Gene

B0024.13

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.By similarity

    Catalytic activityi

    Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

    GO - Biological processi

    1. dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
    2. dolichol metabolic process Source: UniProtKB
    3. polyprenol catabolic process Source: UniProtKB
    4. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_104244. Androgen biosynthesis.
    REACT_183451. Synthesis of Dolichyl-phosphate.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyprenol reductase (EC:1.3.1.94)
    Gene namesi
    ORF Names:B0024.13
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiB0024.13; CE35376; WBGene00007102.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Polyprenol reductasePRO_0000398653Add
    BLAST

    Proteomic databases

    PaxDbiQ17428.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0024.13b.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17428.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330066.
    GeneTreeiENSGT00500000044920.
    HOGENOMiHOG000018885.
    InParanoidiQ7JLP4.
    KOiK12345.
    OMAiTSAPEFN.
    OrthoDBiEOG72ZCFT.
    PhylomeDBiQ17428.

    Family and domain databases

    InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17428-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDRLWEVRQ ALPLYLLVST LGLAISCCFT LICPHVCRLI PALTTYGKAA    50
    DQQEDNSLVE KISVPKKWFK HFYAIGLLTL FICLHTVHSL IYNPNYLHPV 100
    VLKILATLTR SYSIPPITPS TSILALLLIS LHVARRLYET IFVSVYSDSR 150
    MNLFHYAVGI VHYIILPISI MCETQGVASK LPQLHVSIDD ISLTQWAGAV 200
    LFWICNWKQH QLAEQIANTR KGPRGLIRNY AYGICFGGWF NLVSCPHFLF 250
    EICIYLSLFL VIPDAYVYRF IIMFVCINQT FAALITHSWY HKTFPKYPKS 300
    RKALIPYVL 309
    Length:309
    Mass (Da):35,430
    Last modified:July 5, 2004 - v2
    Checksum:i1D4F125A25B3A9EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71178 Genomic DNA. Translation: CAA94885.2.
    PIRiT18648.
    RefSeqiNP_001256209.1. NM_001269280.1.
    UniGeneiCel.9469.

    Genome annotation databases

    EnsemblMetazoaiB0024.13; B0024.13; WBGene00007102.
    GeneIDi179438.
    KEGGicel:CELE_B0024.13.
    UCSCiB0024.13a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71178 Genomic DNA. Translation: CAA94885.2 .
    PIRi T18648.
    RefSeqi NP_001256209.1. NM_001269280.1.
    UniGenei Cel.9469.

    3D structure databases

    ProteinModelPortali Q17428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0024.13b.

    Proteomic databases

    PaxDbi Q17428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0024.13 ; B0024.13 ; WBGene00007102 .
    GeneIDi 179438.
    KEGGi cel:CELE_B0024.13.
    UCSCi B0024.13a. c. elegans.

    Organism-specific databases

    CTDi 179438.
    WormBasei B0024.13 ; CE35376 ; WBGene00007102 .

    Phylogenomic databases

    eggNOGi NOG330066.
    GeneTreei ENSGT00500000044920.
    HOGENOMi HOG000018885.
    InParanoidi Q7JLP4.
    KOi K12345.
    OMAi TSAPEFN.
    OrthoDBi EOG72ZCFT.
    PhylomeDBi Q17428.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_104244. Androgen biosynthesis.
    REACT_183451. Synthesis of Dolichyl-phosphate.

    Miscellaneous databases

    NextBioi 905390.
    PROi Q17428.

    Family and domain databases

    InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPORED_CAEEL
    AccessioniPrimary (citable) accession number: Q17428
    Secondary accession number(s): Q7JLP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3