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Protein

Polyprenol reductase

Gene

B0024.13

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).By similarity

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-CEL-193048 Androgen biosynthesis
R-CEL-446199 Synthesis of Dolichyl-phosphate
UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
Gene namesi
ORF Names:B0024.13
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0024.13 ; CE35376 ; WBGene00007102

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986531 – 309Polyprenol reductaseAdd BLAST309

Proteomic databases

EPDiQ17428
PaxDbiQ17428
PeptideAtlasiQ17428

Expressioni

Gene expression databases

BgeeiWBGene00007102

Interactioni

Protein-protein interaction databases

STRINGi6239.B0024.13

Structurei

3D structure databases

ProteinModelPortaliQ17428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1640 Eukaryota
ENOG4111JQM LUCA
GeneTreeiENSGT00500000044920
HOGENOMiHOG000018885
InParanoidiQ17428
KOiK12345
OMAiRRFYETN
OrthoDBiEOG091G0F09
PhylomeDBiQ17428

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q17428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDRLWEVRQ ALPLYLLVST LGLAISCCFT LICPHVCRLI PALTTYGKAA
60 70 80 90 100
DQQEDNSLVE KISVPKKWFK HFYAIGLLTL FICLHTVHSL IYNPNYLHPV
110 120 130 140 150
VLKILATLTR SYSIPPITPS TSILALLLIS LHVARRLYET IFVSVYSDSR
160 170 180 190 200
MNLFHYAVGI VHYIILPISI MCETQGVASK LPQLHVSIDD ISLTQWAGAV
210 220 230 240 250
LFWICNWKQH QLAEQIANTR KGPRGLIRNY AYGICFGGWF NLVSCPHFLF
260 270 280 290 300
EICIYLSLFL VIPDAYVYRF IIMFVCINQT FAALITHSWY HKTFPKYPKS

RKALIPYVL
Length:309
Mass (Da):35,430
Last modified:July 5, 2004 - v2
Checksum:i1D4F125A25B3A9EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71178 Genomic DNA Translation: CAA94885.2
PIRiT18648
RefSeqiNP_001256209.1, NM_001269280.1
UniGeneiCel.9469

Genome annotation databases

EnsemblMetazoaiB0024.13; B0024.13; WBGene00007102
GeneIDi179438
KEGGicel:CELE_B0024.13
UCSCiB0024.13a c. elegans

Similar proteinsi

Entry informationi

Entry nameiPORED_CAEEL
AccessioniPrimary (citable) accession number: Q17428
Secondary accession number(s): Q7JLP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health