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Protein

Glucosamine 6-phosphate N-acetyltransferase

Gene

gna-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucosamine 6-phosphate N-acetyltransferase (gna-1)
  2. no protein annotated in this organism
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44SubstrateBy similarity1
Binding sitei164SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00529.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine 6-phosphate N-acetyltransferase (EC:2.3.1.4By similarity)
Alternative name(s):
Phosphoglucosamine acetylase
Phosphoglucosamine transacetylase
Gene namesi
Name:gna-1
ORF Names:B0024.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0024.12; CE05156; WBGene00001646; gna-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745561 – 165Glucosamine 6-phosphate N-acetyltransferaseAdd BLAST165

Proteomic databases

EPDiQ17427.
PaxDbiQ17427.
PeptideAtlasiQ17427.
PRIDEiQ17427.

Expressioni

Gene expression databases

BgeeiWBGene00001646.

Interactioni

Protein-protein interaction databases

BioGridi44467. 4 interactors.
DIPiDIP-25958N.
IntActiQ17427. 4 interactors.
MINTiMINT-1068708.
STRINGi6239.B0024.12.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi7 – 10Combined sources4
Helixi11 – 13Combined sources3
Beta strandi22 – 26Combined sources5
Helixi29 – 32Combined sources4
Turni33 – 35Combined sources3
Helixi36 – 43Combined sources8
Helixi51 – 62Combined sources12
Beta strandi69 – 75Combined sources7
Turni76 – 78Combined sources3
Beta strandi81 – 91Combined sources11
Helixi94 – 97Combined sources4
Beta strandi99 – 108Combined sources10
Helixi110 – 112Combined sources3
Helixi117 – 132Combined sources16
Beta strandi135 – 139Combined sources5
Helixi143 – 145Combined sources3
Helixi146 – 150Combined sources5
Turni151 – 153Combined sources3
Beta strandi161 – 163Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AG7X-ray1.55A/B1-165[»]
4AG9X-ray1.76A/B1-165[»]
ProteinModelPortaliQ17427.
SMRiQ17427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 165N-acetyltransferasePROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 95Substrate bindingBy similarity4
Regioni104 – 106Substrate bindingBy similarity3
Regioni114 – 119Acetyl-CoA bindingBy similarity6
Regioni135 – 136Substrate bindingBy similarity2

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3396. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00390000008666.
HOGENOMiHOG000106325.
InParanoidiQ17427.
KOiK00621.
OMAiGRGCYKV.
OrthoDBiEOG091G0EMF.
PhylomeDBiQ17427.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHIFDASVL APHIPSNLPD NFKVRPLAKD DFSKGYVDLL SQLTSVGNLD
60 70 80 90 100
QEAFEKRFEA MRTSVPNYHI VVIEDSNSQK VVASASLVVE MKFIHGAGSR
110 120 130 140 150
GRVEDVVVDT EMRRQKLGAV LLKTLVSLGK SLGVYKISLE CVPELLPFYS
160
QFGFQDDCNF MTQRF
Length:165
Mass (Da):18,459
Last modified:November 1, 1996 - v1
Checksum:i215C7CD7A6165BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017628 mRNA. Translation: BAA36497.1.
Z71178 Genomic DNA. Translation: CAA94884.1.
PIRiT37319.
RefSeqiNP_505654.1. NM_073253.5.
UniGeneiCel.19593.

Genome annotation databases

EnsemblMetazoaiB0024.12; B0024.12; WBGene00001646.
GeneIDi179437.
KEGGicel:CELE_B0024.12.
UCSCiB0024.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017628 mRNA. Translation: BAA36497.1.
Z71178 Genomic DNA. Translation: CAA94884.1.
PIRiT37319.
RefSeqiNP_505654.1. NM_073253.5.
UniGeneiCel.19593.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AG7X-ray1.55A/B1-165[»]
4AG9X-ray1.76A/B1-165[»]
ProteinModelPortaliQ17427.
SMRiQ17427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44467. 4 interactors.
DIPiDIP-25958N.
IntActiQ17427. 4 interactors.
MINTiMINT-1068708.
STRINGi6239.B0024.12.

Proteomic databases

EPDiQ17427.
PaxDbiQ17427.
PeptideAtlasiQ17427.
PRIDEiQ17427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0024.12; B0024.12; WBGene00001646.
GeneIDi179437.
KEGGicel:CELE_B0024.12.
UCSCiB0024.12. c. elegans.

Organism-specific databases

CTDi179437.
WormBaseiB0024.12; CE05156; WBGene00001646; gna-1.

Phylogenomic databases

eggNOGiKOG3396. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00390000008666.
HOGENOMiHOG000106325.
InParanoidiQ17427.
KOiK00621.
OMAiGRGCYKV.
OrthoDBiEOG091G0EMF.
PhylomeDBiQ17427.

Enzyme and pathway databases

UniPathwayiUPA00113; UER00529.
ReactomeiR-CEL-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

PROiQ17427.

Gene expression databases

BgeeiWBGene00001646.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNA1_CAEEL
AccessioniPrimary (citable) accession number: Q17427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.