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Protein

Probable thioredoxin-2

Gene

trx-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei62Deprotonates C-terminal active site CysBy similarity1
Active sitei68NucleophileBy similarity1
Sitei69Contributes to redox potential valueBy similarity1
Sitei70Contributes to redox potential valueBy similarity1
Active sitei71NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thioredoxin-2
Gene namesi
Name:trx-2
ORF Names:B0024.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0024.9a; CE42941; WBGene00007099; trx-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200281 – 145Probable thioredoxin-2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 71Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ17424.
PaxDbiQ17424.
PRIDEiQ17424.

Expressioni

Gene expression databases

BgeeiWBGene00007099.
ExpressionAtlasiQ17424. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ17424. 1 interactor.
STRINGi6239.B0024.9a.

Structurei

3D structure databases

ProteinModelPortaliQ17424.
SMRiQ17424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 144ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000064086.
HOGENOMiHOG000292977.
InParanoidiQ17424.
KOiK03671.
OMAiCRMLTPR.
OrthoDBiEOG091G0UDG.
PhylomeDBiQ17424.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR036249. Thioredoxin-like_sf.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKALKLGSF FARSAISVKP TLATSKMTQL RHFSHGASVF DIDSVEDFTE
60 70 80 90 100
KVIQSSVPVI VDFHAEWCGP CQALGPRLEE KVNGRQGSVL LAKINVDHAG
110 120 130 140
ELAMDYGISA VPTVFAFKNG EKISGFSGVL DDEQLDDFIE DVLAA
Length:145
Mass (Da):15,702
Last modified:January 20, 2009 - v2
Checksum:iCB323515396BCD6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71178 Genomic DNA. Translation: CAA94881.2.
PIRiT18644.
RefSeqiNP_001256207.1. NM_001269278.1.
UniGeneiCel.7582.

Genome annotation databases

EnsemblMetazoaiB0024.9a; B0024.9a; WBGene00007099.
GeneIDi179434.
KEGGicel:CELE_B0024.9.
UCSCiB0024.9. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiTHIO2_CAEEL
AccessioniPrimary (citable) accession number: Q17424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 20, 2009
Last modified: October 25, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families