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Protein

Probable thioredoxin-2

Gene

trx-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei62 – 621Deprotonates C-terminal active site CysBy similarity
Active sitei68 – 681NucleophileBy similarity
Sitei69 – 691Contributes to redox potential valueBy similarity
Sitei70 – 701Contributes to redox potential valueBy similarity
Active sitei71 – 711NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thioredoxin-2
Gene namesi
Name:trx-2
ORF Names:B0024.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0024.9a; CE42941; WBGene00007099; trx-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Probable thioredoxin-2PRO_0000120028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 71Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ17424.
PaxDbiQ17424.

Expressioni

Gene expression databases

ExpressionAtlasiQ17424. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ17424. 1 interaction.
STRINGi6239.B0024.9a.

Structurei

3D structure databases

ProteinModelPortaliQ17424.
SMRiQ17424. Positions 35-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 144106ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000064086.
HOGENOMiHOG000292977.
InParanoidiQ17424.
KOiK03671.
OMAiKINVDHA.
PhylomeDBiQ17424.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKALKLGSF FARSAISVKP TLATSKMTQL RHFSHGASVF DIDSVEDFTE
60 70 80 90 100
KVIQSSVPVI VDFHAEWCGP CQALGPRLEE KVNGRQGSVL LAKINVDHAG
110 120 130 140
ELAMDYGISA VPTVFAFKNG EKISGFSGVL DDEQLDDFIE DVLAA
Length:145
Mass (Da):15,702
Last modified:January 20, 2009 - v2
Checksum:iCB323515396BCD6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71178 Genomic DNA. Translation: CAA94881.2.
PIRiT18644.
RefSeqiNP_001256207.1. NM_001269278.1.
UniGeneiCel.7582.

Genome annotation databases

EnsemblMetazoaiB0024.9a; B0024.9a; WBGene00007099.
GeneIDi179434.
KEGGicel:CELE_B0024.9.
UCSCiB0024.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71178 Genomic DNA. Translation: CAA94881.2.
PIRiT18644.
RefSeqiNP_001256207.1. NM_001269278.1.
UniGeneiCel.7582.

3D structure databases

ProteinModelPortaliQ17424.
SMRiQ17424. Positions 35-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ17424. 1 interaction.
STRINGi6239.B0024.9a.

Proteomic databases

EPDiQ17424.
PaxDbiQ17424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0024.9a; B0024.9a; WBGene00007099.
GeneIDi179434.
KEGGicel:CELE_B0024.9.
UCSCiB0024.9. c. elegans.

Organism-specific databases

CTDi34281.
WormBaseiB0024.9a; CE42941; WBGene00007099; trx-2.

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000064086.
HOGENOMiHOG000292977.
InParanoidiQ17424.
KOiK03671.
OMAiKINVDHA.
PhylomeDBiQ17424.

Miscellaneous databases

PROiQ17424.

Gene expression databases

ExpressionAtlasiQ17424. baseline.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTHIO2_CAEEL
AccessioniPrimary (citable) accession number: Q17424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 20, 2009
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.