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Protein

Probable uridine-cytidine kinase

Gene

B0001.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.
ATP + cytidine = ADP + CMP.

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731SubstrateBy similarity
Binding sitei101 – 1011SubstrateBy similarity
Binding sitei154 – 1541SubstrateBy similarity
Binding sitei164 – 1641SubstrateBy similarity
Binding sitei172 – 1721SubstrateBy similarity
Binding sitei201 – 2011ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-73614. Pyrimidine salvage reactions.
UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable uridine-cytidine kinase (EC:2.7.1.48)
Short name:
UCK
Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase
Gene namesi
ORF Names:B0001.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiB0001.4a; CE37307; WBGene00007089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Probable uridine-cytidine kinasePRO_0000164459Add
BLAST

Proteomic databases

EPDiQ17413.
PaxDbiQ17413.
PRIDEiQ17413.

PTM databases

iPTMnetiQ17413.

Interactioni

Protein-protein interaction databases

IntActiQ17413. 1 interaction.
STRINGi6239.B0001.4.

Structurei

3D structure databases

ProteinModelPortaliQ17413.
SMRiQ17413. Positions 8-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

eggNOGiENOG410IMEH. Eukaryota.
COG0572. LUCA.
HOGENOMiHOG000262756.
InParanoidiQ17413.
KOiK00876.
OMAiFVTHSRM.
OrthoDBiEOG76T9QV.
PhylomeDBiQ17413.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTLKLPLL IGVAGGTSCG KSTIVERIIE NLNANAKQSG RQIDIVHLSL
60 70 80 90 100
HSFYRELSAE EKILAREGKF NFDHPDQINF DLLAETLQNM IDGKTVEIPK
110 120 130 140 150
YDMITSSMNG TVTVEPAKVI IIEGILLLYD ERVRKLLSTK LFVEKNAESR
160 170 180 190 200
LRNRLATYIR DYHRAPLSII RQYTEFVKPA FEEFCRPTKK YADVIIPRGA
210 220 230 240
DNHVATDLIA KNLQETFRKI VVSSDEEEEK ENELVKQGSF RRPFSRPH
Length:248
Mass (Da):28,390
Last modified:May 10, 2005 - v2
Checksum:iF404213A23CF7261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69634 Genomic DNA. Translation: CAA93453.2.
PIRiT18629.
RefSeqiNP_502304.2. NM_069903.2.
UniGeneiCel.13666.

Genome annotation databases

EnsemblMetazoaiB0001.4a; B0001.4a; WBGene00007089.
GeneIDi178160.
KEGGicel:CELE_B0001.4.
UCSCiB0001.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69634 Genomic DNA. Translation: CAA93453.2.
PIRiT18629.
RefSeqiNP_502304.2. NM_069903.2.
UniGeneiCel.13666.

3D structure databases

ProteinModelPortaliQ17413.
SMRiQ17413. Positions 8-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ17413. 1 interaction.
STRINGi6239.B0001.4.

PTM databases

iPTMnetiQ17413.

Proteomic databases

EPDiQ17413.
PaxDbiQ17413.
PRIDEiQ17413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0001.4a; B0001.4a; WBGene00007089.
GeneIDi178160.
KEGGicel:CELE_B0001.4.
UCSCiB0001.4. c. elegans.

Organism-specific databases

CTDi178160.
WormBaseiB0001.4a; CE37307; WBGene00007089.

Phylogenomic databases

eggNOGiENOG410IMEH. Eukaryota.
COG0572. LUCA.
HOGENOMiHOG000262756.
InParanoidiQ17413.
KOiK00876.
OMAiFVTHSRM.
OrthoDBiEOG76T9QV.
PhylomeDBiQ17413.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.
ReactomeiR-CEL-73614. Pyrimidine salvage reactions.

Miscellaneous databases

NextBioi899966.
PROiQ17413.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUCK_CAEEL
AccessioniPrimary (citable) accession number: Q17413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.