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Q17361

- UBP14_CAEEL

UniProt

Q17361 - UBP14_CAEEL

Protein

Ubiquitin carboxyl-terminal hydrolase 14

Gene

usp-14

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111NucleophilePROSITE-ProRule annotation
    Active sitei409 – 4091Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A36.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 14
    Ubiquitin thioesterase 14
    Ubiquitin-specific-processing protease 14
    Gene namesi
    Name:usp-14
    Synonyms:tgt-1
    ORF Names:C13B4.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC13B4.2; CE15615; WBGene00006856; usp-14.

    Subcellular locationi

    GO - Cellular componenti

    1. proteasome complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Ubiquitin carboxyl-terminal hydrolase 14PRO_0000080640Add
    BLAST

    Proteomic databases

    PaxDbiQ17361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ17361.
    SMRiQ17361. Positions 4-80, 101-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 458357USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5207.
    GeneTreeiENSGT00390000009615.
    HOGENOMiHOG000202292.
    InParanoidiQ17361.
    KOiK11843.
    OMAiDWGNLKI.
    OrthoDBiEOG7F7W8H.
    PhylomeDBiQ17361.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q17361-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL    50
    GDDDWEGITI KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY 100
    PCGLANLGNT CYFNSCVQML KEVNELVLKP AEEMRIREHN DRLCHNLATL 150
    FNSLRDKDRA LRSKGEPIKP FAAILTLSDS FPQFEKFKQQ DANECLVSIM 200
    SNVTRIYGLS GWNIESLFRI QTETTMKCLE SDEVSEKKVE RNNQLTCYVN 250
    QDVRFLQTGI KAGFEEEMTR NSEELNRDAK WQKNTQISRL PKYLTVNINR 300
    FFYKESTKTN AKILKSVQFP MQLDTYDLCS QELKDKLVAR RADIKLEEDA 350
    KLERELRKKV LDKEQGDKIF DDGVALPTAF EDDAGSNNSG FYDLKGIITH 400
    KGRSSQDGHY VAWMRSSEDG KWRLFDDEHV TVVDEEAILK TSGGGDWHSA 450
    YVLLYEARVI KQFPELPPAP VPTEVAADTA EPMEVSEKQ 489
    Length:489
    Mass (Da):55,878
    Last modified:April 16, 2002 - v2
    Checksum:i4433F2CC59703A9B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti398 – 3981I → M in AAA74956. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32223 mRNA. Translation: AAA74956.1.
    Z81468, Z83236 Genomic DNA. Translation: CAB03876.1.
    PIRiT19227.
    RefSeqiNP_497006.1. NM_064605.8.
    UniGeneiCel.19745.

    Genome annotation databases

    EnsemblMetazoaiC13B4.2; C13B4.2; WBGene00006856.
    GeneIDi175105.
    KEGGicel:CELE_C13B4.2.
    UCSCiC13B4.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32223 mRNA. Translation: AAA74956.1 .
    Z81468 , Z83236 Genomic DNA. Translation: CAB03876.1 .
    PIRi T19227.
    RefSeqi NP_497006.1. NM_064605.8.
    UniGenei Cel.19745.

    3D structure databases

    ProteinModelPortali Q17361.
    SMRi Q17361. Positions 4-80, 101-458.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A36.

    Proteomic databases

    PaxDbi Q17361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C13B4.2 ; C13B4.2 ; WBGene00006856 .
    GeneIDi 175105.
    KEGGi cel:CELE_C13B4.2.
    UCSCi C13B4.2.1. c. elegans.

    Organism-specific databases

    CTDi 175105.
    WormBasei C13B4.2 ; CE15615 ; WBGene00006856 ; usp-14.

    Phylogenomic databases

    eggNOGi COG5207.
    GeneTreei ENSGT00390000009615.
    HOGENOMi HOG000202292.
    InParanoidi Q17361.
    KOi K11843.
    OMAi DWGNLKI.
    OrthoDBi EOG7F7W8H.
    PhylomeDBi Q17361.

    Miscellaneous databases

    NextBioi 886786.
    PROi Q17361.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Deshpande K.L., Katze J.R.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBP14_CAEEL
    AccessioniPrimary (citable) accession number: Q17361
    Secondary accession number(s): O45248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Caution

    Was originally (PubMed:9851916) thought to be a queuine tRNA-ribosyltransferase.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3