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Q17361

- UBP14_CAEEL

UniProt

Q17361 - UBP14_CAEEL

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Protein
Ubiquitin carboxyl-terminal hydrolase 14
Gene
usp-14, tgt-1, C13B4.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Nucleophile By similarity
Active sitei409 – 4091Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A36.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 14 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 14
Ubiquitin thioesterase 14
Ubiquitin-specific-processing protease 14
Gene namesi
Name:usp-14
Synonyms:tgt-1
ORF Names:C13B4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC13B4.2; CE15615; WBGene00006856; usp-14.

Subcellular locationi

GO - Cellular componenti

  1. proteasome complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Ubiquitin carboxyl-terminal hydrolase 14
PRO_0000080640Add
BLAST

Proteomic databases

PaxDbiQ17361.

Structurei

3D structure databases

ProteinModelPortaliQ17361.
SMRiQ17361. Positions 4-80, 101-458.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 458357USP
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5207.
GeneTreeiENSGT00390000009615.
HOGENOMiHOG000202292.
InParanoidiQ17361.
KOiK11843.
OMAiDWGNLKI.
OrthoDBiEOG7F7W8H.
PhylomeDBiQ17361.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q17361-1 [UniParc]FASTAAdd to Basket

« Hide

MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL    50
GDDDWEGITI KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY 100
PCGLANLGNT CYFNSCVQML KEVNELVLKP AEEMRIREHN DRLCHNLATL 150
FNSLRDKDRA LRSKGEPIKP FAAILTLSDS FPQFEKFKQQ DANECLVSIM 200
SNVTRIYGLS GWNIESLFRI QTETTMKCLE SDEVSEKKVE RNNQLTCYVN 250
QDVRFLQTGI KAGFEEEMTR NSEELNRDAK WQKNTQISRL PKYLTVNINR 300
FFYKESTKTN AKILKSVQFP MQLDTYDLCS QELKDKLVAR RADIKLEEDA 350
KLERELRKKV LDKEQGDKIF DDGVALPTAF EDDAGSNNSG FYDLKGIITH 400
KGRSSQDGHY VAWMRSSEDG KWRLFDDEHV TVVDEEAILK TSGGGDWHSA 450
YVLLYEARVI KQFPELPPAP VPTEVAADTA EPMEVSEKQ 489
Length:489
Mass (Da):55,878
Last modified:April 16, 2002 - v2
Checksum:i4433F2CC59703A9B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti398 – 3981I → M in AAA74956. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32223 mRNA. Translation: AAA74956.1.
Z81468, Z83236 Genomic DNA. Translation: CAB03876.1.
PIRiT19227.
RefSeqiNP_497006.1. NM_064605.8.
UniGeneiCel.19745.

Genome annotation databases

EnsemblMetazoaiC13B4.2; C13B4.2; WBGene00006856.
GeneIDi175105.
KEGGicel:CELE_C13B4.2.
UCSCiC13B4.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32223 mRNA. Translation: AAA74956.1 .
Z81468 , Z83236 Genomic DNA. Translation: CAB03876.1 .
PIRi T19227.
RefSeqi NP_497006.1. NM_064605.8.
UniGenei Cel.19745.

3D structure databases

ProteinModelPortali Q17361.
SMRi Q17361. Positions 4-80, 101-458.
ModBasei Search...

Protein family/group databases

MEROPSi C19.A36.

Proteomic databases

PaxDbi Q17361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C13B4.2 ; C13B4.2 ; WBGene00006856 .
GeneIDi 175105.
KEGGi cel:CELE_C13B4.2.
UCSCi C13B4.2.1. c. elegans.

Organism-specific databases

CTDi 175105.
WormBasei C13B4.2 ; CE15615 ; WBGene00006856 ; usp-14.

Phylogenomic databases

eggNOGi COG5207.
GeneTreei ENSGT00390000009615.
HOGENOMi HOG000202292.
InParanoidi Q17361.
KOi K11843.
OMAi DWGNLKI.
OrthoDBi EOG7F7W8H.
PhylomeDBi Q17361.

Miscellaneous databases

NextBioi 886786.
PROi Q17361.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Deshpande K.L., Katze J.R.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBP14_CAEEL
AccessioniPrimary (citable) accession number: Q17361
Secondary accession number(s): O45248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Was originally (1 Publication) thought to be a queuine tRNA-ribosyltransferase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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