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Reviewed, UniProtKB/Swiss-Prot Q17361 (UBP14_CAEEL)

Last modified November 3, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin carboxyl-terminal hydrolase 14
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 14
    Ubiquitin-specific-processing protease 14
    Deubiquitinating enzyme 14
Gene names
Name: usp-14
Synonyms: tgt-1
ORF Names: C13B4.2
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.

Sequence similarities

Belongs to the peptidase C19 family.

Caution

Was originally (Ref.1) thought to be a queuine tRNA-ribosyltransferase.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Ubiquitin carboxyl-terminal hydrolase 14
PRO_0000080640

Sites

Active site1111 By similarity
Active site4001 By similarity
Active site4091 By similarity

Experimental info

Sequence conflict3981I → M in AAA74956. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q17361-1 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: 4433F2CC59703A9B

FASTA48955,878
        10         20         30         40         50         60 
MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL GDDDWEGITI 

        70         80         90        100        110        120 
KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY PCGLANLGNT CYFNSCVQML 

       130        140        150        160        170        180 
KEVNELVLKP AEEMRIREHN DRLCHNLATL FNSLRDKDRA LRSKGEPIKP FAAILTLSDS 

       190        200        210        220        230        240 
FPQFEKFKQQ DANECLVSIM SNVTRIYGLS GWNIESLFRI QTETTMKCLE SDEVSEKKVE 

       250        260        270        280        290        300 
RNNQLTCYVN QDVRFLQTGI KAGFEEEMTR NSEELNRDAK WQKNTQISRL PKYLTVNINR 

       310        320        330        340        350        360 
FFYKESTKTN AKILKSVQFP MQLDTYDLCS QELKDKLVAR RADIKLEEDA KLERELRKKV 

       370        380        390        400        410        420 
LDKEQGDKIF DDGVALPTAF EDDAGSNNSG FYDLKGIITH KGRSSQDGHY VAWMRSSEDG 

       430        440        450        460        470        480 
KWRLFDDEHV TVVDEEAILK TSGGGDWHSA YVLLYEARVI KQFPELPPAP VPTEVAADTA 


EPMEVSEKQ 

« Hide

References

« Hide 'large scale' references
[1]Deshpande K.L., Katze J.R.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

U32223 mRNA. Translation: AAA74956.1.
Z81468, Z83236 Genomic DNA. Translation: CAB03876.1.
Z83236, Z81468 Genomic DNA. Translation: CAB05785.1.
PIRT19227.
RefSeqNP_497006.1.
UniGeneCel.19745

3D structure databases

HSSPHSSP built from PDB template 1NBF based on UniProtKB Q93009.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ17361.

Genome annotation databases

EnsemblC13B4.2.1; C13B4.2.1; C13B4.2; Caenorhabditis elegans. [Genome view]
C13B4.2.2; C13B4.2.2; C13B4.2; Caenorhabditis elegans. [Genome view]
GeneID175105.
KEGGcel:C13B4.2.
UCSCC13B4.2.1. c. elegans.

Organism-specific databases

CTD175105.
WormBaseWBGene00006856. usp-14.
WormPepC13B4.2. CE15615. [WorfDB]

Phylogenomic databases

OMANSGYYEL.

Enzyme and pathway databases

BRENDA3.1.2.15. 672.

Gene expression databases

ArrayExpressQ17361.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR000626. Ubiquitin.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio886786.

Entry information

Entry nameUBP14_CAEEL
AccessionPrimary (citable) accession number: Q17361
Secondary accession number(s): O45248
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: November 3, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents