ID   PAR3_CAEEL              Reviewed;        1340 AA.
AC   Q17353-3;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 172.
DE   RecName: Full=Isoform c of Partitioning defective protein 3;
DE   AltName: Full=Abnormal embryonic partitioning of cytoplasm protein 3;
GN   Name=par-3 {ECO:0000312|EMBL:AAB18670.1}; ORFNames=F54E7.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAB18670.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:8521491};
RC   TISSUE=Embryo {ECO:0000269|PubMed:8521491};
RX   PubMed=8521491; DOI=10.1016/0092-8674(95)90187-6;
RA   Etemad-Moghadam B., Guo S., Kemphues K.J.;
RT   "Asymmetrically distributed PAR-3 protein contributes to cell polarity and
RT   spindle alignment in early C. elegans embryos.";
RL   Cell 83:743-752(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND INTERACTION WITH PAR-6.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:8898226};
RX   PubMed=8898226; DOI=10.1242/dev.122.10.3133;
RA   Watts J.L., Etemad-Moghadam B., Guo S., Boyd L., Draper B.W., Mello C.C.,
RA   Priess J.R., Kemphues K.J.;
RT   "par-6, a gene involved in the establishment of asymmetry in early C.
RT   elegans embryos, mediates the asymmetric localization of PAR-3.";
RL   Development 122:3133-3140(1996).
RN   [4] {ECO:0000305}
RP   FUNCTION, AND INTERACTION WITH PKC-3.
RX   PubMed=9716526; DOI=10.1242/dev.125.18.3607;
RA   Tabuse Y., Izumi Y., Piano F., Kemphues K.J., Miwa J., Ohno S.;
RT   "Atypical protein kinase C cooperates with PAR-3 to establish embryonic
RT   polarity in Caenorhabditis elegans.";
RL   Development 125:3607-3614(1998).
RN   [5] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH PAR-6 AND PKC-3, AND TISSUE SPECIFICITY.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:9834192};
RX   PubMed=9834192; DOI=10.1242/dev.126.1.127;
RA   Hung T.-J., Kemphues K.J.;
RT   "PAR-6 is a conserved PDZ domain-containing protein that colocalizes with
RT   PAR-3 in Caenorhabditis elegans embryos.";
RL   Development 126:127-135(1999).
RN   [6] {ECO:0000305}
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=13129846; DOI=10.1242/dev.00735;
RA   Nance J., Munro E.M., Priess J.R.;
RT   "C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries
RT   associated with cell adhesion and gastrulation.";
RL   Development 130:5339-5350(2003).
RN   [7]
RP   FUNCTION.
RX   PubMed=14534135; DOI=10.1242/dev.00790;
RA   Tsou M.-F.B., Hayashi A., Rose L.S.;
RT   "LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle
RT   positioning in response to PAR and MES-1/SRC-1 signaling.";
RL   Development 130:5717-5730(2003).
RN   [8]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15151982; DOI=10.1242/dev.01146;
RA   Aono S., Legouis R., Hoose W.A., Kemphues K.J.;
RT   "PAR-3 is required for epithelial cell polarity in the distal spermatheca
RT   of C. elegans.";
RL   Development 131:2865-2874(2004).
RN   [9]
RP   FUNCTION.
RX   PubMed=18694560; DOI=10.1016/j.devcel.2008.06.002;
RA   Panbianco C., Weinkove D., Zanin E., Jones D., Divecha N., Gotta M.,
RA   Ahringer J.;
RT   "A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2)
RT   synthesis enzyme for asymmetric spindle positioning.";
RL   Dev. Cell 15:198-208(2008).
CC   -!- INTERACTION:
CC       Q17353-3; O16502: abu-7; NbExp=2; IntAct=EBI-1812329, EBI-328492;
CC       Q17353-3; H2L055: CELE_F53A10.2; NbExp=2; IntAct=EBI-1812329, EBI-2413872;
CC       Q17353-3; Q22387: CELE_T11B7.1; NbExp=3; IntAct=EBI-1812329, EBI-320525;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=b {ECO:0000269|PubMed:8521491};
CC         IsoId=Q17353-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=Q17353-2; Sequence=VSP_051597;
CC       Name=c;
CC         IsoId=Q17353-3; Sequence=VSP_034689, VSP_051597;
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DR   EnsemblMetazoa; F54E7.3c.1; F54E7.3c.1; WBGene00003918.
DR   EnsemblMetazoa; F54E7.3c.2; F54E7.3c.2; WBGene00003918.
DR   WormBase; F54E7.3c; CE39941; WBGene00003918; par-3.
DR   Proteomes; UP000001940; Chromosome III.
PE   1: Evidence at protein level;
SQ   SEQUENCE   1340 AA;  145588 MW;  390E4FBB0E9236E0 CRC64;
     MHNGRGGRYD VCPPPPPPPY HFNHVHTPPS KVIVQQQKQQ QKAHREPPPS YPASKMTTTN
     DNVTVSKRNF QANEDRIHVH RLECASDGGI LDMDDVLEEV FDLNYDQILA ITDEANGGST
     TPTYSQIQKQ QHHYAQPLPY ARKFDGGPST PIASAFGSVT VNHQAHRAAS PYNVGFARSN
     SRDFAPQPTH SKERRDSVVE VSSFDQIPQS GLRVSTPKPS RQSEDVIDGK PMNQPILRSS
     LRTEASGSRT EEATPVKQSR VTLSPEVEKK LAEQDERKSE RRKHYDKNPG RFARGSDRKS
     RITDALLDAR DRIADQLESQ NPAEETKSQM IRVKIDQGPM PGTSLVTFPP IPEKSENEKQ
     LGIEVNAVFD ESSELPGTSE PTKLSSVQIM KIEDGGRIAK DGRIRVGDCI VAIDGKPVDQ
     MSIIRVRASI SDLAAVTSRP VTLIINRSLE SFLEQESSAK PIQSALQQAN TQYIGHTTVV
     ELIKSSNGFG FTVTGRETAK GERLFYIGTV KPYGVALGHL KSGDRLLEIN GTPTGQWTQS
     EIVEKLKETM VGEKIKFLVS RVSQSAIMST SASSENKENE ETLKVVEEEK IPQKLPLPAL
     MTPPVPKDTP ALSPSGASRF EIVIPFINGS SSAGLGVSLK ARVSKKSNGS KVDCGIFIKN
     VMHGGAAFKE GGLRVDDRIV GVEDIDLEPL DNREAQAALA KKLKEVGMIS SNVRLTISRY
     NECNPGQISR DLSRITVDAS SPSPSSRMSS HTAPDSLLPS PATRGTSSSG ADSSHSRQSS
     ASSAVPAVPA RLTERDSIVS DGTSRNDESE LPDSADPFNR EGLGRKSLSE KRGMGAAADP
     QHIKLFQDIK HQRQNSAPTS STQKRSKSQP RSSSQRNYRS PMKLVDLPTT AAASASTNSQ
     NLDDSDMLNR RSQSMESINR PVESILRGTG QIPTGSSSKV QFMQAASPDQ HPFPPGAALL
     RLKNEESRSR DKSRRKSMGN AMRNFFGFGS KSRDASPEKT PTESVQLRSV ERPKSIIDER
     NNGSSERAPP PLPPHQSQRR GSGGNVFVDY GEPYGLIPQY PHNTTSGYES YADSELYDRY
     AAHRYHPRGG PIIDEDEYIY RQQSTSGNSP INTSSYVNYG LPASNAYHVG SRIPPQTSSG
     SISKTSGAMR RVYPAEYDED VAYHQQIPQQ STRYQQGSGS GRGNADYHHM FNSWFAYTGG
     GAVGAAPVIK SSYGSSPVRI AAASAIERGE SFVVEPVSGS SASATDRRGR STSSGAVASG
     SSSTGFQYAA KEKYADARSG KFNGGSTRLF IPRHGGGLSA AAFATNFGGE AYETRGGGAG
     GSPSQYRRRD QGPPHRFPQY
//