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Protein

Partitioning defective protein 3

Gene

par-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo (PubMed:8521491, PubMed:9716526). Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces (PubMed:8898226, PubMed:9834192). Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first embryonic division (PubMed:14534135, PubMed:18694560).8 Publications

GO - Biological processi

  • asymmetric cell division Source: WormBase
  • asymmetric protein localization Source: UniProtKB
  • cell adhesion Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • establishment of cell polarity Source: WormBase
  • establishment of mitotic spindle localization Source: UniProtKB
  • establishment of mitotic spindle orientation Source: WormBase
  • establishment or maintenance of cell polarity Source: UniProtKB
  • gastrulation Source: UniProtKB
  • gonadal mesoderm development Source: UniProtKB-KW
  • gonad development Source: UniProtKB
  • polarity specification of anterior/posterior axis Source: WormBase
  • single fertilization Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Cell cycle, Cell division, Differentiation, Fertilization, Gastrulation, Gonadal differentiation

Enzyme and pathway databases

ReactomeiR-CEL-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective protein 3
Alternative name(s):
Abnormal embryonic partitioning of cytoplasm protein 3
Gene namesi
Name:par-3Imported
ORF Names:F54E7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54E7.3a; CE28449; WBGene00003918; par-3.
F54E7.3b; CE28450; WBGene00003918; par-3.
F54E7.3c; CE39941; WBGene00003918; par-3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850741 – 1379Partitioning defective protein 3Add BLAST1379

Proteomic databases

PaxDbiQ17353.
PeptideAtlasiQ17353.

PTM databases

iPTMnetiQ17353.

Expressioni

Tissue specificityi

Asymmetrically distributed at the periphery of the zygote and in dividing blastomeres of the germline lineage. Coexpressed with par-6; patchy expression observed at the periphery after completion of meiosis I and in meiosis II. On completion of metaphase II, expression is restricted to the anterior 85% of embryo length; this decreases to 55% in embryos between prophase and telophase of the first mitosis. During the first cleavage, expression is detected in the advancing furrow. Transiently coexpressed and colocalized asymmetrically with par-6 and pkc-3, in the developing somatic gonad, including the spermathecal precursor cells of L4 larvae.4 Publications

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiWBGene00003918.
ExpressionAtlasiQ17353. baseline.

Interactioni

Subunit structurei

Required, together with pkc-3, for the localization of par-6; par-6 is involved in localizing/maintaining par-3 at the cell periphery. Interacts with par-6 and pkc-3 for localization at the periphery of anterior cortex of the embryo.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi41010. 5 interactors.
DIPiDIP-25317N.
IntActiQ17353. 55 interactors.
MINTiMINT-1103392.
STRINGi6239.F54E7.3b.2.

Structurei

3D structure databases

ProteinModelPortaliQ17353.
SMRiQ17353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini381 – 483PDZ 1PROSITE-ProRule annotationAdd BLAST103
Domaini515 – 599PDZ 2PROSITE-ProRule annotationAdd BLAST85
Domaini659 – 750PDZ 3PROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili606 – 626Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi776 – 819Ser-richAdd BLAST44

Sequence similaritiesi

Belongs to the PAR3 family.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITAJ. Eukaryota.
ENOG410ZDVK. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000018783.
InParanoidiQ17353.
PhylomeDBiQ17353.

Family and domain databases

InterProiView protein in InterPro
IPR021922. Par3/HAL_N.
IPR001478. PDZ.
IPR036034. PDZ_sf.
PfamiView protein in Pfam
PF12053. DUF3534. 1 hit.
PF00595. PDZ. 2 hits.
SMARTiView protein in SMART
SM00228. PDZ. 3 hits.
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b1 Publication (identifier: Q17353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASSTSSSS TSCPEGGEPS GSCKSSDEGE STLKKRMQQY GIASGYANSS
60 70 80 90 100
ISTLDRSQYQ SLPLNGTRRV TVQFGRMKIV VPWKESDQTV GQLADAALLR
110 120 130 140 150
YKKARGMANE DRIHVHRLEC ASDGGILDMD DVLEEVFDLN YDQILAITDE
160 170 180 190 200
ANGGSTTPTY SQIQKQQHHY AQPLPYARKF DGGPSTPIAS AFGSVTVNHQ
210 220 230 240 250
AHRAASPYNV GFARSNSRDF APQPTHSKER RDSVVEVSSF DQIPQSGLRV
260 270 280 290 300
STPKPSRQSE DVIDGKPMNQ PILRSSLRTE ASGSRTEEAT PVKQSRVTLS
310 320 330 340 350
PEVEKKLAEQ DERKSERRKH YDKNPGRFAR GSDRKSRITD ALLDARDRIA
360 370 380 390 400
DQLESQNPAE ETKSQMIRVK IDQGPMPGTS LVTFPPIPEK SENEKQLGIE
410 420 430 440 450
VNAVFDESSE LPGTSEPTKL SSVQIMKIED GGRIAKDGRI RVGDCIVAID
460 470 480 490 500
GKPVDQMSII RVRASISDLA AVTSRPVTLI INRSLESFLE QESSAKPIQS
510 520 530 540 550
ALQQANTQYI GHTTVVELIK SSNGFGFTVT GRETAKGERL FYIGTVKPYG
560 570 580 590 600
VALGHLKSGD RLLEINGTPT GQWTQSEIVE KLKETMVGEK IKFLVSRVSQ
610 620 630 640 650
SAIMSTSASS ENKENEETLK VVEEEKIPQK LPLPALMTPP VPKDTPALSP
660 670 680 690 700
SGASRFEIVI PFINGSSSAG LGVSLKARVS KKSNGSKVDC GIFIKNVMHG
710 720 730 740 750
GAAFKEGGLR VDDRIVGVED IDLEPLDNRE AQAALAKKLK EVGMISSNVR
760 770 780 790 800
LTISRYNECN PGQISRDLSR ITVDASSPSP SSRMSSHTAP DSLLPSPATR
810 820 830 840 850
GTSSSGADSS HSRQSSASSA VPAVPARLTE RDSIVSDGTS RNDESELPDS
860 870 880 890 900
ADPFNREGLG RKSLSEKRGM GAAADPQHIK LFQDIKHQRQ NSAPTSSTQK
910 920 930 940 950
RSKSQPRSSS QRNYRSPMKL VDLPTTAAAS ASTNSQNLDD SDMLNRRSQS
960 970 980 990 1000
MESINRPVES ILRGTGQIPT GSSSKVQFMQ AASPDQHPFP PGAALLRLKN
1010 1020 1030 1040 1050
EESRSRDKSR RKSMGNPFSA MRNFFGFGSK SRDASPEKTP TESVQLRSVE
1060 1070 1080 1090 1100
RPKSIIDERN NGSSERAPPP LPPHQSQRRG SGGNVFVDYG EPYGLIPQYP
1110 1120 1130 1140 1150
HNTTSGYESY ADSELYDRYA AHRYHPRGGP IIDEDEYIYR QQSTSGNSPI
1160 1170 1180 1190 1200
NTSSYVNYGL PASNAYHVGS RIPPQTSSGS ISKTSGAMRR VYPAEYDEDV
1210 1220 1230 1240 1250
AYHQQIPQQS TRYQQGSGSG RGNADYHHMF NSWFAYTGGG AVGAAPVIKS
1260 1270 1280 1290 1300
SYGSSPVRIA AASAIERGES FVVEPVSGSS ASATDRRGRS TSSGAVASGS
1310 1320 1330 1340 1350
SSTGFQYAAK EKYADARSGK FNGGSTRLFI PRHGGGLSAA AFATNFGGEA
1360 1370
YETRGGGAGG SPSQYRRRDQ GPPHRFPQY
Length:1,379
Mass (Da):149,326
Last modified:November 1, 1996 - v1
Checksum:i3B498E7652CFF17D
GO
Isoform a (identifier: Q17353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1017-1019: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,376
Mass (Da):148,994
Checksum:i92CF11545C626856
GO
Isoform c (identifier: Q17353-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MSASSTSSSS...LLRYKKARGM → MHNGRGGRYD...NVTVSKRNFQ
     1017-1019: Missing.

Note: No experimental confirmation available.
Show »
Length:1,340
Mass (Da):145,588
Checksum:i390E4FBB0E9236E0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0346891 – 107MSASS…KARGM → MHNGRGGRYDVCPPPPPPPY HFNHVHTPPSKVIVQQQKQQ QKAHREPPPSYPASKMTTTN DNVTVSKRNFQ in isoform c. CuratedAdd BLAST107
Alternative sequenceiVSP_0515971017 – 1019Missing in isoform a and isoform c. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25032 mRNA. Translation: AAB18670.1.
FO080172 Genomic DNA. Translation: CCD61764.1.
FO080172 Genomic DNA. Translation: CCD61765.1.
FO080172 Genomic DNA. Translation: CCD61766.1.
RefSeqiNP_001022607.1. NM_001027436.2. [Q17353-1]
NP_001040857.1. NM_001047392.1. [Q17353-3]
NP_498217.2. NM_065816.6. [Q17353-2]
UniGeneiCel.5328.

Genome annotation databases

EnsemblMetazoaiF54E7.3b.1; F54E7.3b.1; WBGene00003918. [Q17353-1]
F54E7.3b.2; F54E7.3b.2; WBGene00003918. [Q17353-1]
GeneIDi175783.
UCSCiF54E7.3b. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAR3_CAEEL
AccessioniPrimary (citable) accession number: Q17353
Secondary accession number(s): Q27GV0, Q95QE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families