Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 1

Gene

sodh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1
Binding sitei204NADBy similarity1
Binding sitei208NADBy similarity1
Binding sitei342NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi270 – 272NADBy similarity3

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: UniProtKB
  • ethanol metabolic process Source: GO_Central
  • NADH oxidation Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Sorbitol dehydrogenase family protein 1
Gene namesi
Name:sodh-1
ORF Names:K12G11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK12G11.3; CE12212; WBGene00010790; sodh-1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606931 – 349Alcohol dehydrogenase 1Add BLAST349

Proteomic databases

EPDiQ17334.
PaxDbiQ17334.
PeptideAtlasiQ17334.
PRIDEiQ17334.

2D gel databases

World-2DPAGEi0011:Q17334.
0020:Q17334.

PTM databases

iPTMnetiQ17334.

Expressioni

Gene expression databases

BgeeiWBGene00010790.

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

BioGridi44651. 4 interactors.
DIPiDIP-26303N.
IntActiQ17334. 3 interactors.
MINTiMINT-117645.
STRINGi6239.K12G11.3.

Structurei

3D structure databases

ProteinModelPortaliQ17334.
SMRiQ17334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 152Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
GeneTreeiENSGT00550000075207.
HOGENOMiHOG000294685.
InParanoidiQ17334.
KOiK13953.
OMAiYKGLKMT.
OrthoDBiEOG091G0GBX.
PhylomeDBiQ17334.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like_sf.
IPR036291. NAD(P)-bd_dom_sf.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVELPSTQR ALVFDTWNGP LEVRQVPVPS PADDEILVKI EYSGICHSDL
60 70 80 90 100
HVWLGDLKDM SVCPLVGGHE GAGSVVQIGK NVTGWQLGDK AGVKLMNFNC
110 120 130 140 150
LNCEFCKKGH EPLCHHIQNY GFDRSGTFQE YLTIRGVDAA KINKDTNLAA
160 170 180 190 200
AAPILCAGVT VYKALKESNV APGQIIVLTG AGGGLGSLAI QYACAMGMRV
210 220 230 240 250
VAMDHGSKEA HCKGLGAEWF VDAFETPDIV SHITKLTEGG PHGVINFAVA
260 270 280 290 300
RKPMEQAVEY VRKRGTVVFV GLPKDSKVTF DTTPFIFNAI TIKGSIVGSR
310 320 330 340
LDVDEAMEFV TRGIVKVPLE LVKLEDVPAV YQRMLDGKIN SRAVVDFSL
Length:349
Mass (Da):37,697
Last modified:May 30, 2000 - v2
Checksum:i94B2752CFCAC977E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 112EP → DA in AAB03373 (PubMed:7608988).Curated2
Sequence conflicti207S → R in AAB03373 (PubMed:7608988).Curated1
Sequence conflicti248A → G in AAB03373 (PubMed:7608988).Curated1
Sequence conflicti307M → I in AAB03373 (PubMed:7608988).Curated1
Sequence conflicti344V → G in AAB03373 (PubMed:7608988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81570 Genomic DNA. Translation: CAB04604.1.
U18780 mRNA. Translation: AAB03373.1.
PIRiT23626.
RefSeqiNP_505991.1. NM_073590.5.
UniGeneiCel.23484.

Genome annotation databases

EnsemblMetazoaiK12G11.3; K12G11.3; WBGene00010790.
GeneIDi179627.
KEGGicel:CELE_K12G11.3.
UCSCiK12G11.3. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiADH1_CAEEL
AccessioniPrimary (citable) accession number: Q17334
Secondary accession number(s): O45688
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 22, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families