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Reviewed, UniProtKB/Swiss-Prot Q17334 (ADH1_CAEEL)

Last modified June 16, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Sorbitol dehydrogenase family protein 1
Gene names
Name: sodh-1
ORF Names: K12G11.3
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer Potential.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

kin-2P306251EBI-313947,EBI-325716

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Alcohol dehydrogenase 1
PRO_0000160693

Regions

Nucleotide binding180 – 1867NAD By similarity
Nucleotide binding270 – 2723NAD By similarity
Compositional bias149 – 1524Poly-Ala

Sites

Metal binding461Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1061Zinc 2 By similarity
Metal binding1141Zinc 2 By similarity
Metal binding1561Zinc 1; catalytic By similarity
Binding site2041NAD By similarity
Binding site2081NAD By similarity
Binding site3421NAD By similarity

Experimental info

Sequence conflict111 – 1122EP → DA in AAB03373. Ref.2
Sequence conflict2071S → R in AAB03373. Ref.2
Sequence conflict2481A → G in AAB03373. Ref.2
Sequence conflict3071M → I in AAB03373. Ref.2
Sequence conflict3441V → G in AAB03373. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q17334-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 94B2752CFCAC977E

FASTA34937,697
        10         20         30         40         50         60 
MTVELPSTQR ALVFDTWNGP LEVRQVPVPS PADDEILVKI EYSGICHSDL HVWLGDLKDM 

        70         80         90        100        110        120 
SVCPLVGGHE GAGSVVQIGK NVTGWQLGDK AGVKLMNFNC LNCEFCKKGH EPLCHHIQNY 

       130        140        150        160        170        180 
GFDRSGTFQE YLTIRGVDAA KINKDTNLAA AAPILCAGVT VYKALKESNV APGQIIVLTG 

       190        200        210        220        230        240 
AGGGLGSLAI QYACAMGMRV VAMDHGSKEA HCKGLGAEWF VDAFETPDIV SHITKLTEGG 

       250        260        270        280        290        300 
PHGVINFAVA RKPMEQAVEY VRKRGTVVFV GLPKDSKVTF DTTPFIFNAI TIKGSIVGSR 

       310        320        330        340 
LDVDEAMEFV TRGIVKVPLE LVKLEDVPAV YQRMLDGKIN SRAVVDFSL

« Hide

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References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family."
Glasner J.D., Kocher T.D., Collins J.J.
J. Mol. Evol. 41:46-53(1995) [PubMed: 7608988] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 111-349.

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Cross-references

Sequence databases

Z81570 Genomic DNA. Translation: CAB04604.1.
U18780 mRNA. Translation: AAB03373.1.
PIRT23626.
RefSeqNP_505991.1.
UniGeneCel.23484

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:26303N.
IntActQ17334. 4 interactions.

Genome annotation databases

EnsemblK12G11.3. Caenorhabditis elegans. [Contig view]
GeneID179627.
KEGGcel:K12G11.3.

Organism-specific databases

WormBaseWBGene00010790. sodh-1.
WormPepK12G11.3. CE12212. [WorfDB]

Phylogenomic databases

OMAQ17334. TEGGPHG.

Enzyme and pathway databases

BRENDA1.1.1.1. 672.

Gene expression databases

ArrayExpressQ17334.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio906202.

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Entry information

Entry nameADH1_CAEEL
AccessionPrimary (citable) accession number: Q17334
Secondary accession number(s): O45688
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents