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Protein

Fatty acid-binding protein

Gene
N/A
Organism
Blomia tropicalis (Mite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Binds the natural fluorescent fatty acid cis-parinaric acid and oleic acid by competition, but not retinol, retinoic acid, cholesterol, dansylated or anthroxylated fatty acids such as dansyl-DL-aminocaprylic acid and 12-(9-anthroyloxy)-stereate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105Fatty acidBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein
Alternative name(s):
Bt6
Allergen: Blo t 13
OrganismiBlomia tropicalis (Mite)
Taxonomic identifieri40697 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaEchimyopodidaeBlomia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei150. Blo t 13.
3150. Blo t 13.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674201 – 130Fatty acid-binding proteinAdd BLAST130

Structurei

3D structure databases

ProteinModelPortaliQ17284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 127Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIEGKYKLE KSDNFDKFLD ELGVGFMVKT AAKTLKPTLE VDVQGDTYVF
60 70 80 90 100
RSLSTFKNTE IKFKLGEEFE EDRADGKRVK TVVNKEGDNK FIQTQYGDKE
110 120 130
VKIVRDFQGD DVVVTASVGD VTSVRTYKRI
Length:130
Mass (Da):14,800
Last modified:November 1, 1996 - v1
Checksum:iF9CFDA2BC8AE4879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58106 mRNA. Translation: AAC80579.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFABP_BLOTA
AccessioniPrimary (citable) accession number: Q17284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families