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Protein

Bombyxin B-10

Gene

BBXB10

Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Bombyxin B-10
Short name:
BBX-B10
Alternative name(s):
4K-prothoracicotropic hormone
Short name:
4K-PTTH
Cleaved into the following 2 chains:
Gene namesi
Name:BBXB10
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Peptidei20 – 4324Bombyxin B-10 B chainPRO_0000016016Add
BLAST
Propeptidei46 – 6419Bombyxin B-10 C peptidePRO_0000016017Add
BLAST
Peptidei67 – 8721Bombyxin B-10 A chainPRO_0000016018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 73Interchain (between B and A chains)By similarity
Disulfide bondi39 ↔ 86Interchain (between B and A chains)By similarity
Disulfide bondi72 ↔ 77By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Structurei

3D structure databases

ProteinModelPortaliQ17194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ17194.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR017097. Bombyxin.
IPR027285. Bombyxin_B.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PIRSFiPIRSF037038. Bombyxin. 1 hit.
PIRSF500313. Bombyxin_B. 1 hit.
PRINTSiPR02003. BOMBYXIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q17194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTILIFLVV ISLMYSGEAQ EVAHTYCGRH LADTLADLCF GVEKRSGAQY
60 70 80
APYFWTRQYL GSRGKRSVVD ECCFRPCTLD VLLSYCD
Length:87
Mass (Da):9,881
Last modified:November 1, 1996 - v1
Checksum:i46DC86279B28C933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00787 Genomic DNA. Translation: BAA00683.1.
PIRiJQ0836.
S69490.
RefSeqiNP_001121788.1. NM_001128316.1.
UniGeneiBmo.11329.

Genome annotation databases

GeneIDi100169715.
KEGGibmor:100169715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00787 Genomic DNA. Translation: BAA00683.1.
PIRiJQ0836.
S69490.
RefSeqiNP_001121788.1. NM_001128316.1.
UniGeneiBmo.11329.

3D structure databases

ProteinModelPortaliQ17194.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100169715.
KEGGibmor:100169715.

Organism-specific databases

CTDi100169715.

Phylogenomic databases

InParanoidiQ17194.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR017097. Bombyxin.
IPR027285. Bombyxin_B.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PIRSFiPIRSF037038. Bombyxin. 1 hit.
PIRSF500313. Bombyxin_B. 1 hit.
PRINTSiPR02003. BOMBYXIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBXB10_BOMMO
AccessioniPrimary (citable) accession number: Q17194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.