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Protein

Vinculin

Gene
N/A
Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vinculin
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
Proteomesi
  • UP000006672 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 993993VinculinPRO_0000064257Add
BLAST

Interactioni

Subunit structurei

Exhibits self-association properties.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ17162.
SMRiQ17162. Positions 810-987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati258 – 3641071Add
BLAST
Repeati373 – 4801082Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 4802232 X repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi738 – 79053Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 4 hits.
PfamiPF01044. Vinculin. 1 hit.
[Graphical view]
SUPFAMiSSF47220. SSF47220. 7 hits.

Sequencei

Sequence statusi: Complete.

Q17162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVFHTKTIE GILEPVAQQV SRLVILHEEA EDGNAVLDLT LPVGAVSRAV
60 70 80 90 100
DNLIKVGYDT CHSSDDRILQ ADMPPALQRV EASSRLLEDA CHMLRADPYS
110 120 130 140 150
SVARKKLIEG ARGILQGTSA LLLSFDESEV RKIIRGCRKV LDYLAVAEVI
160 170 180 190 200
ESMDDLAQFV KDISPWLTRV SRNIDAREKE LTHQVHREIL LRCMDTVKTL
210 220 230 240 250
SPIMICAMKI FIQITEESQR GQQEAAENRN YLAQRMTDEM NEIIRVLQLT
260 270 280 290 300
TYDEDEWDSD NVTVMRKALS AAQSLLTSAL DWLADSRGRA GATGEKAIRR
310 320 330 340 350
IVDYSERIAA RALPEDARLI RATVSDITSM TDSLCELRNQ GGDSQGLASG
360 370 380 390 400
CANRLKELVG TKEISGILPS ALTNTQRTGG THPAHTVTGR LEQALRWMDN
410 420 430 440 450
PGVDDNGLGL QAVKAMTSEA GNLQPIYSHL QNVRKFVDLC VEIDRQADQL
460 470 480 490 500
ADLEHRGLGN PPAAHAIRNQ LRNKLRELVD IMKKVITDRV VEDFADISTP
510 520 530 540 550
LKQFVDAVYA SPTIVNRELS FEEKAHNLDD HSSRCANTAL LVAKCGPCKN
560 570 580 590 600
KKTVEAIIEA ANQVNAMTPQ VIKAGKIRLH NDSDSANLHF DNLRREYSDV
610 620 630 640 650
LNRLRSHVDD AIDTSDFIRA SEQAMRQYTV YCENAIRNNE PQQMVDNTSQ
660 670 680 690 700
IARFGNRVLM TAKNEADNSE EPSFVHRVNN AARRLHSAIP PMVNQAKQVA
710 720 730 740 750
LNPRHGGNAQ SWRDANEHLL SAVRQVGDAI TGAGGSRPPS QNLLVESVPP
760 770 780 790 800
KAPTSPIVHD RIYIREDIPT PPRPPPPVEI SPPPRPPPPP ETDDEEETRA
810 820 830 840 850
FWERYPLLGA SSQPILSAAH NLHQELRQWS SHENEIVAAA KRMAILMARL
860 870 880 890 900
SQLVRGEGGT KKDLVDCAKA IADSSEEVTR LAVQLARQCT VIKMRMTLLQ
910 920 930 940 950
VCERIPTIAT QLKILSTVKA TMLGSQATIG PYGQPIDGSE EDEEAMQQLV
960 970 980 990
LNAQNLMQSV KDTVRAAEAA SIKIRTNSGL RLRWIRKPMW SNF
Length:993
Mass (Da):110,188
Last modified:November 1, 1996 - v1
Checksum:i318CB75FA33E4E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07023 mRNA. Translation: AAB96842.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07023 mRNA. Translation: AAB96842.1.

3D structure databases

ProteinModelPortaliQ17162.
SMRiQ17162. Positions 810-987.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 4 hits.
PfamiPF01044. Vinculin. 1 hit.
[Graphical view]
SUPFAMiSSF47220. SSF47220. 7 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiVINC_BRUMA
AccessioniPrimary (citable) accession number: Q17162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.